eprintid: 17841
rev_number: 15
eprint_status: archive
userid: 1329
dir: disk0/00/01/78/41
datestamp: 2014-12-11 08:03:51
lastmod: 2015-01-24 19:16:46
status_changed: 2014-12-11 08:03:51
type: article
metadata_visibility: show
creators_name: Kamphues, Carsten
creators_name: Wittschieber, Daniel
creators_name: Klauschen, Frederick
creators_name: Kasajima, Atsuko
creators_name: Dietel, Manfred
creators_name: Schmidt, Sven-Christian
creators_name: Glanemann, Matthias
creators_name: Bahra, Marcus
creators_name: Neuhaus, Peter
creators_name: Weichert, Wilko
creators_name: Stenzinger, Albrecht
title: Prolyl hydroxylase domain 2 protein is a strong prognostic marker in human gastric cancer
subjects: 610
divisions: 912000
abstract: Objective: According to recent research, prolyl hydroxylase domain 2 protein (PHD2) plays an important role in human carcinogenesis by inducing neovascularization and tumor growth. The aim of this study was to evaluate PHD2 expression patterns in primary gastric adenocarcinoma and to test for a potential predictive value of PHD2 expression in gastric cancer patients. Methods: In a total of 121 patients, PHD2 expression was investigated by immunohistochemistry in paraffin- embedded tissue and correlated with clinicopathological parameters and patient survival. Results: 64 of 121 gastric carcinomas (52.9%) showed PHD2 expression in tumor cell cytoplasm. In univariate analysis, PHD2- negative patients had a significantly shortened survival in comparison
date: 2012
publisher: S. Karger AG
id_scheme: DOI
id_number: 10.11588/heidok.00017841
ppn_swb: 1654624012
own_urn: urn:nbn:de:bsz:16-heidok-178410
language: eng
bibsort: KAMPHUESCAPROLYLHYDR2012
full_text_status: public
publication: Pathobiology
volume: 79
number: 1
pagerange: 11-17
issn: 1015-2008
citation:   Kamphues, Carsten ; Wittschieber, Daniel ; Klauschen, Frederick ; Kasajima, Atsuko ; Dietel, Manfred ; Schmidt, Sven-Christian ; Glanemann, Matthias ; Bahra, Marcus ; Neuhaus, Peter ; Weichert, Wilko ; Stenzinger, Albrecht  (2012) Prolyl hydroxylase domain 2 protein is a strong prognostic marker in human gastric cancer.  Pathobiology, 79 (1).  pp. 11-17.  ISSN 1015-2008     
document_url: https://archiv.ub.uni-heidelberg.de/volltextserver/17841/1/PAT2012079001011.pdf