title: Development and application of a multi-modality inverse treatment planning system
creator: Nill, Simeon
subject: 530
subject: 530 Physics
description: The introduction of intensity-modulated radiation therapy (IMRT) opened new possibilities for the treatment planning process. Most of the existing treatment planning (TP) tools for the IMRT are focusing on the use of photons for the treatment. To achieve a very high computional speed only simplified dose calculation algorithms are used.   Furthermore, approximations are made  during the calculation of the fluence matrix. This thesis develops an IMRT planning tool which can be used with any available radiation modality and makes use of  improved dose calculation algorithms.  For the dose calculation engine a method was developed where the dose deposited in every voxel by all beams is precalculated and for later use stored in a dose matrix. This enables the use  of advanced dose calculation algorithms and the simultaneous optimization of different radiation modalities.  The new TP system   was applied to clinical patient data for proton and photon IMRT plans. For the delivery of the proton IMRT plans two promising delivery techniques,  'distal edge tracking' (DET) and the 3D technique, were compared  with each other. By using the DET technique dose distributions as good as for the 3D technique were achieved but the optimization time and the expected delivery time are reduced by a factor 10. In addition, no significant differences in the effect of organ motion  and particle range uncertainties are observed for either technique.
date: 2001
type: Dissertation
type: info:eu-repo/semantics/doctoralThesis
type: NonPeerReviewed
format: application/pdf
identifier: https://archiv.ub.uni-heidelberg.de/volltextserverhttps://archiv.ub.uni-heidelberg.de/volltextserver/1802/1/diss.pdf
identifier: DOI:10.11588/heidok.00001802
identifier: urn:nbn:de:bsz:16-opus-18020
identifier:   Nill, Simeon  (2001) Development and application of a multi-modality inverse treatment planning system.  [Dissertation]     
relation: https://archiv.ub.uni-heidelberg.de/volltextserver/1802/
rights: info:eu-repo/semantics/openAccess
rights: http://archiv.ub.uni-heidelberg.de/volltextserver/help/license_urhg.html
language: eng