eprintid: 1809
rev_number: 9
eprint_status: archive
userid: 1
dir: disk0/00/00/18/09
datestamp: 2001-11-15 00:00:00
lastmod: 2014-04-03 11:23:46
status_changed: 2012-08-14 15:02:47
type: doctoralThesis
metadata_visibility: show
creators_name: Borkenstein, Klaus
title: Modeling and computer simulation of tumor growth and tumor response to radiotherapy
title_de: Modellierung und Computersimulation des Tumorwachstums und der Tumorantwort auf Strahlentherapie
ispublished: pub
subjects: ddc-530
divisions: i-850300
adv_faculty: af-13
keywords: Biologische Modellierung , Monte-Carlo Methoden , Tumorwachstum , Tumorangiogenese , Tumorantwort auf StrahlentherapieBiological modeling , Monte-Carlo methods , Tumor growth , Tumor angiogenesis , Tumor response to radiotherapy
cterms_swd: Medizinische Physik
abstract_translated_text: In radiotherapy, total dose and time-dose patterns are currently chosen according to the clinical expertise of the radiation oncologist.  To aid radiation oncologists in the treatment planning process, it is important to quantitatively assess tumor response to irradiation.  The objective of this work is to devise a cellular radiobiological model and to develop three-dimensional simulation methods that allow simulation of tumors with clinically relevant sizes.  Simulations of unperturbed tumor proliferation are compared to corresponding experimental growth curves in vivo.  The most important radiobiological parameters are identified and their influence on tumor growth and tumor response to irradiation is quantified.  Total doses needed by conventional and accelerated fractionation schemes for tumor control are given for different radiobiological parameters, such as cell cycle time, growth fraction and radiosensitivity.
abstract_translated_lang: eng
class_scheme: pacs
class_labels: 87.53.Vb, 87.53.-j, 87.53.Wz
date: 2001
date_type: published
id_scheme: DOI
id_number: 10.11588/heidok.00001809
ppn_swb: 1643240129
own_urn: urn:nbn:de:bsz:16-opus-18099
date_accepted: 2001-11-07
advisor: HASH(0x55a718475b98)
language: eng
bibsort: BORKENSTEIMODELINGAN2001
full_text_status: public
citation:   Borkenstein, Klaus  (2001) Modeling and computer simulation of tumor growth and tumor response to radiotherapy.  [Dissertation]     
document_url: https://archiv.ub.uni-heidelberg.de/volltextserver/1809/1/diss_bork.pdf