title: Continuous oral chloroquine as a novel route for Plasmodium prophylaxis and cure in experimental murine models
creator: Lewis, Matthew D.
creator: Pfeil, Johannes
creator: Müller, Ann-Kristin
subject: ddc-610
subject: 610 Medical sciences Medicine
description: Background: Chloroquine (CQ) is utilized as both cure and prophylaxis to Plasmodium infection. In animal studies, CQ administration to experimental animals is via intraperitoneal (i.p.) injection of a single dose that varies from daily to several times per week. Such daily administration can be distressing to the animals and provoke aggressive behaviors that may affect the immune responses of the animal and interfere with data read-outs.  Findings: We describe a novel, viable and efficacious prophylactic and curative administration route whereby chloroquine is continuously supplied in the drinking water to experimental animals. The prophylactic effect is robust and the curative effect against patent blood stage infection comparable to the traditional route of i.p. administration. Continuous drinking water administration may decrease animal stress responses and thus improve the reliability of experimental data.  
publisher: Biomed Central
date: 2011
type: Article
type: info:eu-repo/semantics/article
type: NonPeerReviewed
format: application/pdf
identifier: https://archiv.ub.uni-heidelberg.de/volltextserverhttps://archiv.ub.uni-heidelberg.de/volltextserver/18663/1/13104_2011_Article_1000.pdf
identifier: DOI:
identifier: urn:nbn:de:bsz:16-heidok-186634
identifier:   Lewis, Matthew D. ; Pfeil, Johannes ; Müller, Ann-Kristin  (2011) Continuous oral chloroquine as a novel route for Plasmodium prophylaxis and cure in experimental murine models.  BMC Research Notes, 4 (262).  pp. 1-4.  ISSN 1756-0500     
relation: https://archiv.ub.uni-heidelberg.de/volltextserver/18663/
rights: info:eu-repo/semantics/openAccess
rights: Please see front page of the work (Sorry, Dublin Core plugin does not recognise license id)
language: eng