eprintid: 18663
rev_number: 17
eprint_status: archive
userid: 1589
dir: disk0/00/01/86/63
datestamp: 2015-05-26 13:53:46
lastmod: 2024-02-28 03:55:01
status_changed: 2015-05-26 13:53:46
type: article
metadata_visibility: show
creators_name: Lewis, Matthew D.
creators_name: Pfeil, Johannes
creators_name: Müller, Ann-Kristin
title: Continuous oral chloroquine as a novel route for Plasmodium prophylaxis and cure in experimental murine models
subjects: ddc-610
divisions: i-910500
divisions: i-911700
abstract: Background: Chloroquine (CQ) is utilized as both cure and prophylaxis to Plasmodium infection. In animal studies, CQ administration to experimental animals is via intraperitoneal (i.p.) injection of a single dose that varies from daily to several times per week. Such daily administration can be distressing to the animals and provoke aggressive behaviors that may affect the immune responses of the animal and interfere with data read-outs.  Findings: We describe a novel, viable and efficacious prophylactic and curative administration route whereby chloroquine is continuously supplied in the drinking water to experimental animals. The prophylactic effect is robust and the curative effect against patent blood stage infection comparable to the traditional route of i.p. administration. Continuous drinking water administration may decrease animal stress responses and thus improve the reliability of experimental data.  
date: 2011
publisher: Biomed Central
id_scheme: DOI
ppn_swb: 165704923X
own_urn: urn:nbn:de:bsz:16-heidok-186634
language: eng
bibsort: LEWISMATTHCONTINUOUS2011
full_text_status: public
publication: BMC Research Notes
volume: 4
number: 262
place_of_pub: London
pagerange: 1-4
issn: 1756-0500
citation:   Lewis, Matthew D. ; Pfeil, Johannes ; Müller, Ann-Kristin  (2011) Continuous oral chloroquine as a novel route for Plasmodium prophylaxis and cure in experimental murine models.  BMC Research Notes, 4 (262).  pp. 1-4.  ISSN 1756-0500     
document_url: https://archiv.ub.uni-heidelberg.de/volltextserver/18663/1/13104_2011_Article_1000.pdf