title: Insights into the regulation of muscle metabolism and growth in  mice and hibernating grizzly bears
creator: Mugahid (Megahed), Douaa (Doaa)
subject: ddc-500
subject: 500 Natural sciences and mathematics
subject: ddc-570
subject: 570 Life sciences
description: Mechanotransduction plays an important role in the regulation of muscle growth and metabolic  signalling in striated muscle. Muscle disuse reduces mechanical input to the muscle, which  results in a loss of muscle mass. Here I describe how titin's mechanically activated kinase  domain affects muscle growth and metabolism via p62 and Akt signalling. I also demonstrate  how changes in metabolic and growth signalling in hibernating grizzly bear help maintain  muscle mass under conditions that induce muscle loss in humans and mice. I validated some of  these changes in murine myotubes demonstrating that increasing non-essential amino acid  levels, increasing Pdk4 levels or suppressing Serpinf1 has a positive effect on growth signalling  that extends to non-hibernators.
date: 2015
type: Dissertation
type: info:eu-repo/semantics/doctoralThesis
type: NonPeerReviewed
format: application/pdf
identifier: https://archiv.ub.uni-heidelberg.de/volltextserverhttps://archiv.ub.uni-heidelberg.de/volltextserver/19027/1/step2.pdf
identifier: DOI:10.11588/heidok.00019027
identifier: urn:nbn:de:bsz:16-heidok-190276
identifier:   Mugahid (Megahed), Douaa (Doaa)  (2015) Insights into the regulation of muscle metabolism and growth in mice and hibernating grizzly bears.  [Dissertation]     
relation: https://archiv.ub.uni-heidelberg.de/volltextserver/19027/
rights: info:eu-repo/semantics/openAccess
rights: http://archiv.ub.uni-heidelberg.de/volltextserver/help/license_urhg.html
language: eng