%0 Generic
%A Mugahid (Megahed), Douaa (Doaa)
%D 2015
%F heidok:19027
%K Muscle, Hibernation, Metabolism, Growth, Cell size
%R 10.11588/heidok.00019027
%T Insights into the regulation of muscle metabolism and growth in  mice and hibernating grizzly bears
%U https://archiv.ub.uni-heidelberg.de/volltextserver/19027/
%X Mechanotransduction plays an important role in the regulation of muscle growth and metabolic  signalling in striated muscle. Muscle disuse reduces mechanical input to the muscle, which  results in a loss of muscle mass. Here I describe how titin's mechanically activated kinase  domain affects muscle growth and metabolism via p62 and Akt signalling. I also demonstrate  how changes in metabolic and growth signalling in hibernating grizzly bear help maintain  muscle mass under conditions that induce muscle loss in humans and mice. I validated some of  these changes in murine myotubes demonstrating that increasing non-essential amino acid  levels, increasing Pdk4 levels or suppressing Serpinf1 has a positive effect on growth signalling  that extends to non-hibernators.