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primary topic: Insights into the regulation of muscle metabolism and growth in mice and hibernating grizzly bears

Insights into the regulation of muscle metabolism and growth in mice and hibernating grizzly bears
type: Article
abstract: Mechanotransduction plays an important role in the regulation of muscle growth and metabolic signalling in striated muscle. Muscle disuse reduces mechanical input to the muscle, which results in a loss of muscle mass. Here I describe how titin's mechanically activated kinase domain affects muscle growth and metabolism via p62 and Akt signalling. I also demonstrate how changes in metabolic and growth signalling in hibernating grizzly bear help maintain muscle mass under conditions that induce muscle loss in humans and mice. I validated some of these changes in murine myotubes demonstrating that increasing non-essential amino acid levels, increasing Pdk4 levels or suppressing Serpinf1 has a positive effect on growth signalling that extends to non-hibernators.
date: 2015
author list: authors
type: EPrint
type: DoctoralThesisEPrint
is part of: repository
has document: Insights into the regulation of muscle metabolism and growth in mice and hibernating grizzly bears (PDF)
has document: Insights into the regulation of muscle metabolism and growth in mice and hibernating grizzly bears (Other)
subject: 500 Naturwissenschaften und Mathematik
subject: 570 Biowissenschaften, Biologie

Insights into the regulation of muscle metabolism and growth in mice and hibernating grizzly bears (PDF)
type: Document
has file: step2.pdf
has part: step2.pdf

Douaa (Doaa) Mugahid (Megahed)
type: Person
given name: Douaa (Doaa)
family name: Mugahid (Megahed)

Insights into the regulation of muscle metabolism and growth in mice and hibernating grizzly bears (Other)
type: Document
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Insights into the regulation of muscle metabolism and growth in mice and hibernating grizzly bears (Other)
type: Document
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Insights into the regulation of muscle metabolism and growth in mice and hibernating grizzly bears (Other)
type: Document
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Insights into the regulation of muscle metabolism and growth in mice and hibernating grizzly bears (Other)
type: Document
is version of: Insights into the regulation of muscle metabolism and growth in mice and hibernating grizzly bears (PDF)
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Insights into the regulation of muscle metabolism and growth in mice and hibernating grizzly bears (Other)
type: Document
is version of: Insights into the regulation of muscle metabolism and growth in mice and hibernating grizzly bears (PDF)
is volatile version of: Insights into the regulation of muscle metabolism and growth in mice and hibernating grizzly bears (PDF)
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primary topic: Insights into the regulation of muscle metabolism and growth in mice and hibernating grizzly bears

500 Naturwissenschaften und Mathematik
type: Concept
preferred label: 500 Natural sciences and mathematics @en

570 Biowissenschaften, Biologie
type: Concept
preferred label: 570 Life sciences @en