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Insights into the regulation of muscle metabolism and growth in mice and hibernating grizzly bears
Mechanotransduction plays an important role in the regulation of muscle growth and metabolic signalling in striated muscle. Muscle disuse reduces mechanical input to the muscle, which results in a loss of muscle mass. Here I describe how titin's mechanically activated kinase domain affects muscle growth and metabolism via p62 and Akt signalling. I also demonstrate how changes in metabolic and growth signalling in hibernating grizzly bear help maintain muscle mass under conditions that induce muscle loss in humans and mice. I validated some of these changes in murine myotubes demonstrating that increasing non-essential amino acid levels, increasing Pdk4 levels or suppressing Serpinf1 has a positive effect on growth signalling that extends to non-hibernators.
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500 Naturwissenschaften und Mathematik
500 Natural sciences and mathematics
570 Biowissenschaften, Biologie
570 Life sciences