<> "The repository administrator has not yet configured an RDF license."^^ . <> . . "Insights into the regulation of muscle metabolism and growth in\r\nmice and hibernating grizzly bears"^^ . "Mechanotransduction plays an important role in the regulation of muscle growth and metabolic\r\nsignalling in striated muscle. Muscle disuse reduces mechanical input to the muscle, which\r\nresults in a loss of muscle mass. Here I describe how titin's mechanically activated kinase\r\ndomain affects muscle growth and metabolism via p62 and Akt signalling. I also demonstrate\r\nhow changes in metabolic and growth signalling in hibernating grizzly bear help maintain\r\nmuscle mass under conditions that induce muscle loss in humans and mice. I validated some of\r\nthese changes in murine myotubes demonstrating that increasing non-essential amino acid\r\nlevels, increasing Pdk4 levels or suppressing Serpinf1 has a positive effect on growth signalling\r\nthat extends to non-hibernators."^^ . "2015" . . . . . . . "Douaa (Doaa)"^^ . "Mugahid (Megahed)"^^ . "Douaa (Doaa) Mugahid (Megahed)"^^ . . . . . . "Insights into the regulation of muscle metabolism and growth in\r\nmice and hibernating grizzly bears (PDF)"^^ . . . "step2.pdf"^^ . . . "Insights into the regulation of muscle metabolism and growth in\r\nmice and hibernating grizzly bears (Other)"^^ . . . . . . "indexcodes.txt"^^ . . . "Insights into the regulation of muscle metabolism and growth in\r\nmice and hibernating grizzly bears (Other)"^^ . . . . . . "lightbox.jpg"^^ . . . "Insights into the regulation of muscle metabolism and growth in\r\nmice and hibernating grizzly bears (Other)"^^ . . . . . . "preview.jpg"^^ . . . "Insights into the regulation of muscle metabolism and growth in\r\nmice and hibernating grizzly bears (Other)"^^ . . . . . . "medium.jpg"^^ . . . "Insights into the regulation of muscle metabolism and growth in\r\nmice and hibernating grizzly bears (Other)"^^ . . . . . . "small.jpg"^^ . . "HTML Summary of #19027 \n\nInsights into the regulation of muscle metabolism and growth in \nmice and hibernating grizzly bears\n\n" . "text/html" . . . "500 Naturwissenschaften und Mathematik"@de . "500 Natural sciences and mathematics"@en . . . "570 Biowissenschaften, Biologie"@de . "570 Life sciences"@en . .