eprintid: 19351
rev_number: 35
eprint_status: archive
userid: 1589
dir: disk0/00/01/93/51
datestamp: 2015-11-25 10:29:04
lastmod: 2024-03-16 09:56:49
status_changed: 2015-11-25 10:29:04
type: article
metadata_visibility: show
creators_name: Förster, Robert
creators_name: Bruckner, Thomas
creators_name: Bostel, Tilman
creators_name: Schlampp, Ingmar
creators_name: Debus, Jürgen
creators_name: Rief, Harald
title: Prognostic factors for survival of women with unstable spinal bone metastases from breast cancer
subjects: 610
divisions: 911400
divisions: 911800
abstract: Background: Bone metastases are an important clinical issue in women with breast cancer. Particularly, unstable spinal bone metastases (SBM) are a major cause of severe morbidity and reduced quality of life (QoL) due to frequent immobilization. Radiotherapy (RT) is the major treatment modality and is capable of promoting re-ossification and improving stability. Since local therapy response is excellent, survival of these patients with unstable SBM is of high clinical importance. We therefore conducted this analysis to assess survival and to determine prognostic factors for bone survival (BS) in women with breast cancer and unstable SBM.   Methods: A total population of 92 women with unstable SBM from breast cancer who were treated with RT at our department between January 2000 and January 2012 was retrospectively investigated. We calculated overall survival (OS) and BS (time between first diagnosis of bone metastases until death) with the Kaplan-Meier method and assessed prognostic factors for BS with a Cox regression model.   Results: Mean age at first diagnosis of breast cancer was 60.8 years ± SD 12.4 years. OS after 1, 2 and 5 years was 84.8, 66.3 and 50 %, respectively. BS after 1, 2 and 5 years was 62.0, 33.7 and 12 %, respectively. An age > 50 years (p < .001; HR 1.036 [CI 1.015–1.057]), the presence of a single bone metastasis (p = .002; HR 0.469 [CI 0.292–0.753]) and triple negative phenotype (p < .001; HR 1.068 [CI 0.933–1.125]) were identified as independent prognostic factors for BS.   Conclusions: Our analysis demonstrated a short survival of women with breast cancer and unstable SBM. Age, presence of a solitary SBM and triple-negative phenotype correlated with survival. Our results may have an impact on therapeutic decisions in the future and offer a rationale for future prospective investigations.  
date: 2015
publisher: BioMed Central
id_scheme: DOI
ppn_swb: 453408877
own_urn: urn:nbn:de:bsz:16-heidok-193510
language: eng
bibsort: FORSTERROBPROGNOSTIC2015
full_text_status: public
publication: Radiation oncology
volume: 10
number: 144
place_of_pub: London
pagerange: 1-4
issn: 1748-717X
citation:   Förster, Robert ; Bruckner, Thomas ; Bostel, Tilman ; Schlampp, Ingmar ; Debus, Jürgen ; Rief, Harald  (2015) Prognostic factors for survival of women with unstable spinal bone metastases from breast cancer.  Radiation oncology, 10 (144).  pp. 1-4.  ISSN 1748-717X     
document_url: https://archiv.ub.uni-heidelberg.de/volltextserver/19351/1/13014_2015_Article_458.pdf