TY  - JOUR
A1  - Riffel, Johannes H.
A1  - Andre, Florian
A1  - Maertens, Malte
A1  - Rost, Franziska
A1  - Keller, Marius G. P.
A1  - Giusca, Sorin
A1  - Seitz, Sebastian
A1  - Kristen, Arnt V.
A1  - Müller, Matthias
A1  - Giannitsis, Evangelos
A1  - Korosoglou, Grigorios
A1  - Katus, Hugo A.
A1  - Buss, Sebastian J.
ID  - heidok19356
AV  - public
Y1  - 2015///
JF  - Journal of cardiovascular magnetic resonance
EP  - 9
PB  - BioMed Central
TI  - Fast assessment of long axis strain with standard cardiovascular magnetic resonance: a validation study of a novel parameter with reference values
CY  - London
IS  - 69
UR  - https://archiv.ub.uni-heidelberg.de/volltextserver/19356/
N2  - Background: Assessment of longitudinal function with cardiovascular magnetic resonance (CMR) is limited to measurement of systolic excursion of the mitral annulus (MAPSE) or elaborate strain imaging modalities. The aim of this study was to develop a fast assessable parameter for the measurement of long axis strain (LAS) with CMR.   Methods: 40 healthy volunteers and 125 patients with different forms of cardiomyopathy were retrospectively analyzed. Four different approaches for the assessment of LAS with CMR measuring the distance between the LV apex and a line connecting the origins of the mitral valve leaflets in enddiastole and endsystole were evaluated. Values for LAS were calculated according to the strain formula.   Results: LAS derived from the distance of the epicardial apical border to the midpoint of the line connecting the mitral valve insertion points (LAS-epi/mid) proved to be the most reliable parameter for the assessment of LAS among the different approaches. LAS-epi/mid displayed the highest sensitivity (81.6 %) and specificity (97.5 %), furthermore showing the best correlation with feature tracking (FTI) derived transmural longitudinal strain (r?=?0.85). Moreover, LAS-epi/mid was non-inferior to FTI in discriminating controls from patients (Area under the curve (AUC)?=?0.95 vs. 0.94, p?=?NS). The time required for analysis of LAS-epi/mid was significantly shorter than for FTI (67?±?8 s vs. 180?±?14 s, p?<?0.0001). Additionally, LAS-epi/mid performed significantly better than MAPSE (Delta AUC?=?0.09; p?<?0.005) and the ejection fraction (Delta AUC?=?0.11; p?=?0.0002). Reference values were derived from 234 selected healthy volunteers. Mean value for LAS-epi/mid was ?17.1?±?2.3 %. Mean values for men were significantly lower compared to women (?16.5?±?2.2 vs. -17.9?±?2.1 %; p?<?0.0001), while LAS decreased with age.   Conclusions: LAS-epi/mid is a novel and fast assessable parameter for the analysis of global longitudinal function with non-inferiority compared to transmural longitudinal strain.  
VL  - 17
SP  - 1
SN  - 1532-429X
ER  -