eprintid: 19366
rev_number: 30
eprint_status: archive
userid: 1589
dir: disk0/00/01/93/66
datestamp: 2015-12-01 11:59:08
lastmod: 2024-05-03 12:24:26
status_changed: 2015-12-01 11:59:08
type: article
metadata_visibility: show
creators_name: Scharp, Maike
creators_name: Hauswald, Henrik
creators_name: Bischof, Marc
creators_name: Debus, Jürgen
creators_name: Combs, Stephanie Elisabeth
title: Re-irradiation in the treatment of patients with cerebral metastases of solid tumors: retrospective analysis
subjects: 610
divisions: 911400
abstract: Background: Goal of this retrospective analysis was to evaluate the role of repeat whole brain radiotherapy in the palliative care of patients with brain metastases due to solid tumors.   Methods: Data regarding demographic data, primary tumor, metastasis, radiotherapy and symptoms were compiled on 134 patients with cerebral metastases that received repeat whole brain radiotherapy (WBRT) in our clinic between 2002 and 2011.   Results: The analyzed group consisted of 63 (47%) women and 71 (53%) men with a median age of 57 at the start of re-irradiation. Most frequent primary site was the lung (87%). Sixty patients with lung cancer received the first WBRT prophylactically. At the time of re-WBRT 81% of all patients suffered from additional extracerebral metastases. Time between first and second WBRT was a median of 13.4 months. Full dose for the first WBRT was 30 Gy in 2.0 Gy single dose, for the second 20 Gy in 2.0 Gy single dose. At the start of the Re-WBRT 81 patients (60.4%) had mild, 32 (23.9%) severe neurological symptoms, 21 patients (15.7%) were asymptomatic. The median Karnofsky performance status was 70%. Overall, re-WBRT was tolerated satisfactorily. Main side effects were fatigue, erythema and focal alopecia, 10% of patients discontinued treatment before reaching the planned dose. Median survival was 2.8 months since the end of the re-WBRT with good performance status at the start of the re-irradiation being a key indicator for longer survival. Fifty-two patients (39%) showed a clinical improvement of neurological symptoms after the therapy, 59 patients (44%) remained stable, 23 patients (17%) showed worse symptoms.   Conclusions: From this large patient collective we were able to show that re-WBRT can be an important therapeutic option with low rate of acute side effects for patients in adequate general condition.  
date: 2014
publisher: BioMed Central
id_scheme: DOI
ppn_swb: 1653547537
own_urn: urn:nbn:de:bsz:16-heidok-193669
language: eng
bibsort: SCHARPMAIKREIRRADIAT2014
full_text_status: public
publication: Radiation Oncology
volume: 9
number: 4
place_of_pub: London
pagerange: 1-8
issn: 1748-717X
citation:   Scharp, Maike ; Hauswald, Henrik ; Bischof, Marc ; Debus, Jürgen ; Combs, Stephanie Elisabeth  (2014) Re-irradiation in the treatment of patients with cerebral metastases of solid tumors: retrospective analysis.  Radiation Oncology, 9 (4).  pp. 1-8.  ISSN 1748-717X     
document_url: https://archiv.ub.uni-heidelberg.de/volltextserver/19366/1/13014_2013_Article_1206.pdf