<> "The repository administrator has not yet configured an RDF license."^^ . <> . . . "Association of low serum TGF-β level in hantavirus infected patients with severe disease"^^ . "Background: Hantaviruses are emerging zoonotic pathogens which cause hemorrhagic fever with renal syndrome, an immune-mediated pathogenesis is discussed. The aim of the present study was to investigate the role of TGF-β expression in acute hantavirus infection. Results: We retrospectively studied 77 patients hospitalised with acute Puumala infection during a hantavirus epidemic in Germany in 2012. Hantavirus infection was confirmed by positive anti-Puumala hantavirus IgG and IgM. Plasma levels of transforming growth factor (TGF)-β1 and TGF-β2 were analysed. Based on glomerular filtration rate on admission, patients were divided in mild and severe course of disease. Puumala virus RNA was detected by PCR amplification of the viral L segment gene. Out of 77 Puumala virus infected patients, 52 (68%) were male. A seasonal distribution was detected in our cohort with a peak in summer 2012, the highest incidence was observed in the age group of 30–39 years. Puumala virus RNA was detectable in 4/77 cases. Patients with severe disease had a significant longer hospital stay than patients with mild disease (6.2 vs 3.6 days). Thrombocyte count (186 vs 225 per nl), serum TGF-β1 (74 vs 118 ng/l) and TGF-β2 (479 vs 586 pg/l) were significantly lower in severe compared to mild disease. However, C-reactive protein (CRP) was significantly higher in patients with severe disease (62 vs 40 mg/l). TGF-β1/Cr was the most sensitive and specific marker associated with renal dysfunction. Conclusion: High serum CRP and low serum TGF-β in the early phase of hantavirus infection is associated with a severe course of disease. Our results support the hypothesis of an immune-mediated pathogenesis in hantavirus infection. "^^ . "2015" . . "16" . "19" . . "BioMed Central"^^ . . . "BMC immunology"^^ . . . "14712172" . . . . . . . . . . . . . . . . . . . . . . . . . . . . . "Gerhard"^^ . "Opelz"^^ . "Gerhard Opelz"^^ . . "Volker"^^ . "Daniel"^^ . "Volker Daniel"^^ . . "Imad"^^ . "Lahdou"^^ . "Imad Lahdou"^^ . . "Mahmoud"^^ . "Sadeghi"^^ . "Mahmoud Sadeghi"^^ . . "Mojdeh Heidary"^^ . "Navid"^^ . "Mojdeh Heidary Navid"^^ . . "Jakob"^^ . "Ettinger"^^ . "Jakob Ettinger"^^ . . "Martin"^^ . "Zeier"^^ . "Martin Zeier"^^ . . "Jörg"^^ . "Hofmann"^^ . "Jörg Hofmann"^^ . . "Paul"^^ . "Schnitzler"^^ . "Paul Schnitzler"^^ . . . . . . "Association of low serum TGF-β level in hantavirus infected patients with severe disease (PDF)"^^ . . . "12865_2015_Article_85.pdf"^^ . . . "Association of low serum TGF-β level in hantavirus infected patients with severe disease (Other)"^^ . . . . . . "indexcodes.txt"^^ . . . "Association of low serum TGF-β level in hantavirus infected patients with severe disease (Other)"^^ . . . . . . "lightbox.jpg"^^ . . . "Association of low serum TGF-β level in hantavirus infected patients with severe disease (Other)"^^ . . . . . . "preview.jpg"^^ . . . "Association of low serum TGF-β level in hantavirus infected patients with severe disease (Other)"^^ . . . . . . "medium.jpg"^^ . . . "Association of low serum TGF-β level in hantavirus infected patients with severe disease (Other)"^^ . . . . . . "small.jpg"^^ . . "HTML Summary of #19370 \n\nAssociation of low serum TGF-β level in hantavirus infected patients with severe disease\n\n" . "text/html" . . . "610 Medizin"@de . "610 Medical sciences Medicine"@en . .