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primary topic: Association of low serum TGF-β level in hantavirus infected patients with severe disease

Association of low serum TGF-β level in hantavirus infected patients with severe disease
type: AcademicArticle
type: Article
abstract: Background: Hantaviruses are emerging zoonotic pathogens which cause hemorrhagic fever with renal syndrome, an immune-mediated pathogenesis is discussed. The aim of the present study was to investigate the role of TGF-β expression in acute hantavirus infection. Results: We retrospectively studied 77 patients hospitalised with acute Puumala infection during a hantavirus epidemic in Germany in 2012. Hantavirus infection was confirmed by positive anti-Puumala hantavirus IgG and IgM. Plasma levels of transforming growth factor (TGF)-β1 and TGF-β2 were analysed. Based on glomerular filtration rate on admission, patients were divided in mild and severe course of disease. Puumala virus RNA was detected by PCR amplification of the viral L segment gene. Out of 77 Puumala virus infected patients, 52 (68%) were male. A seasonal distribution was detected in our cohort with a peak in summer 2012, the highest incidence was observed in the age group of 30–39 years. Puumala virus RNA was detectable in 4/77 cases. Patients with severe disease had a significant longer hospital stay than patients with mild disease (6.2 vs 3.6 days). Thrombocyte count (186 vs 225 per nl), serum TGF-β1 (74 vs 118 ng/l) and TGF-β2 (479 vs 586 pg/l) were significantly lower in severe compared to mild disease. However, C-reactive protein (CRP) was significantly higher in patients with severe disease (62 vs 40 mg/l). TGF-β1/Cr was the most sensitive and specific marker associated with renal dysfunction. Conclusion: High serum CRP and low serum TGF-β in the early phase of hantavirus infection is associated with a severe course of disease. Our results support the hypothesis of an immune-mediated pathogenesis in hantavirus infection.
date: 2015
volume: 16
issue: 19
is part of: BMC immunology
author list: authors
type: EPrint
type: ArticleEPrint
is part of: repository
has document: Association of low serum TGF-β level in hantavirus infected patients with severe disease (PDF)
has document: Association of low serum TGF-β level in hantavirus infected patients with severe disease (Other)
subject: 610 Medizin

Association of low serum TGF-β level in hantavirus infected patients with severe disease (PDF)
type: Document
has file: 12865_2015_Article_85.pdf
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BioMed Central
type: Organization

BMC immunology
type: Collection
issn: 14712172

Imad Lahdou
type: Person
given name: Imad
family name: Lahdou

Mojdeh Heidary Navid
type: Person
given name: Mojdeh Heidary
family name: Navid

Paul Schnitzler
type: Person
given name: Paul
family name: Schnitzler

Mahmoud Sadeghi
type: Person
given name: Mahmoud
family name: Sadeghi

Gerhard Opelz
type: Person
given name: Gerhard
family name: Opelz

Jörg Hofmann
type: Person
given name: Jörg
family name: Hofmann

Martin Zeier
type: Person
given name: Martin
family name: Zeier

Jakob Ettinger
type: Person
given name: Jakob
family name: Ettinger

Volker Daniel
type: Person
given name: Volker
family name: Daniel

Association of low serum TGF-β level in hantavirus infected patients with severe disease (Other)
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Association of low serum TGF-β level in hantavirus infected patients with severe disease (Other)
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Association of low serum TGF-β level in hantavirus infected patients with severe disease (Other)
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Association of low serum TGF-β level in hantavirus infected patients with severe disease (Other)
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Association of low serum TGF-β level in hantavirus infected patients with severe disease (Other)
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primary topic: Association of low serum TGF-β level in hantavirus infected patients with severe disease

610 Medizin
type: Concept
preferred label: 610 Medical sciences Medicine @en