title: Autonomic nervous system and hypothalamic–pituitary–adrenal axis response to experimentally induced cold pain in adolescent non-suicidal self-injury – study protocol
creator: König, Julian
creator: Rinnewitz, Lena
creator: Warth, Marco
creator: Kaess, Michael
subject: 610
subject: 610 Medical sciences Medicine
description: Background: Adolescent non-suicidal self-injury (NSSI) is associated with altered sensitivity to experimentally induced pain. Adolescents engaging in NSSI report greater pain threshold and pain tolerance, as well as lower pain intensity and pain unpleasantness compared to healthy controls. The experience of pain is associated with reactivity of both the autonomic nervous system (ANS) and the hypothalamic–pituitary–adrenal (HPA) axis. However, previous research has not yet systematically addressed differences in the physiological response to experimentally induced pain comparing adolescents with NSSI and age- and sex-matched healthy controls.   Methods/Design: Adolescents with NSSI and healthy controls undergo repeated painful stimulation with the cold pressor task. ANS activity is continuously recorded throughout the procedure to assess changes in heart rate and heart rate variability. Blood pressure is monitored and saliva is collected prior to and after nociceptive stimulation to assess levels of saliva cortisol.   Discussion: The study will provide evidence whether lower pain sensitivity in adolescents with NSSI is associated with blunted physiological and endocrinological responses to experimentally induced pain compared to healthy controls. Extending on the existing evidence on altered pain sensitivity in NSSI, measured by self-reports and behavioural assessments, this is the first study to take a systematic approach in evaluating the physiological response to experimentally induced pain in adolescent NSSI.   Trial Registration: Deutsche Register Klinischer Studien, Study ID: DRKS00007807  ; Trial Registration Date: 13.02.2015  
publisher: BioMed Central
date: 2015
type: Article
type: info:eu-repo/semantics/article
type: NonPeerReviewed
format: application/pdf
identifier: https://archiv.ub.uni-heidelberg.de/volltextserverhttps://archiv.ub.uni-heidelberg.de/volltextserver/19371/1/12888_2015_Article_544.pdf
identifier: DOI:http://dx.doi.org/10.1186/s12888-015-0544-4
identifier: urn:nbn:de:bsz:16-heidok-193713
identifier:   König, Julian ; Rinnewitz, Lena ; Warth, Marco ; Kaess, Michael  (2015) Autonomic nervous system and hypothalamic–pituitary–adrenal axis response to experimentally induced cold pain in adolescent non-suicidal self-injury – study protocol.  BMC psychiatry, 15 (150).  pp. 1-8.  ISSN 1471-244X     
relation: https://archiv.ub.uni-heidelberg.de/volltextserver/19371/
rights: info:eu-repo/semantics/openAccess
rights: Please see front page of the work (Sorry, Dublin Core plugin does not recognise license id)
language: eng