title: Ischemic biomarker heart-type fatty acid binding protein (hFABP) in acute heart failure - diagnostic and prognostic insights compared to NT-proBNP and troponin I
creator: Hoffmann, Ursula
creator: Espeter, Florian
creator: Weiß, Christel
creator: Ahmad-Nejad, Parviz
creator: Lang, Siegfried
creator: Brückmann, Martina
creator: Akin, Ibrahim
creator: Neumaier, Michael
creator: Borggrefe, Martin
creator: Behnes, Michael
subject: ddc-610
subject: 610 Medical sciences Medicine
description: Background: To evaluate diagnostic and long-term prognostic values of hFABP compared to NT-proBNP and troponin I (TnI) in patients presenting to the emergency department (ED) suspected of acute heart failure (AHF).   Methods: 401 patients with acute dyspnea or peripheral edema, 122 suffering from AHF, were prospectively enrolled and followed up to 5 years. hFABP combined with NT-proBNP versus NT-proBNP alone was tested for AHF diagnosis. Prognostic value of hFABP versus TnI was evaluated in models predicting all-cause mortality (ACM) and AHF related rehospitalization (AHF-RH) at 1 and 5 years, including 11 conventional risk factors plus NT-proBNP.   Results: Additional hFABP measurements improved diagnostic specificity and positive predictive value (PPV) of sole NT-proBNP testing at the cutoff <300 ng/l to “rule out” AHF. Highest hFABP levels (4th quartile) were associated with increased ACM (hazard ratios (HR): 2.1–2.5; p = 0.04) and AHF-RH risk at 5 years (HR 2.8–8.3, p = 0.001). ACM was better characterized in prognostic models including TnI, whereas AHF-RH was better characterized in prognostic models including hFABP. Cox analyses revealed a 2 % increase of ACM risk and 3–7 % increase of AHF-RH risk at 5 years by each unit increase of hFABP of 10 ng/ml.   Conclusions: Combining hFABP plus NT-proBNP (<300 ng/l) only improves diagnostic specificity and PPV to rule out AHF. hFABP may improve prognosis for long-term AHF-RH, whereas TnI may improve prognosis for ACM.   Trial registration: ClinicalTrials.gov identifier: NCT00143793  .  
publisher: BioMed Central
date: 2015
type: Article
type: info:eu-repo/semantics/article
type: NonPeerReviewed
format: application/pdf
identifier: https://archiv.ub.uni-heidelberg.de/volltextserverhttps://archiv.ub.uni-heidelberg.de/volltextserver/19376/1/12872_2015_Article_26.pdf
identifier: DOI:
identifier: urn:nbn:de:bsz:16-heidok-193766
identifier:   Hoffmann, Ursula ; Espeter, Florian ; Weiß, Christel ; Ahmad-Nejad, Parviz ; Lang, Siegfried ; Brückmann, Martina ; Akin, Ibrahim ; Neumaier, Michael ; Borggrefe, Martin ; Behnes, Michael  (2015) Ischemic biomarker heart-type fatty acid binding protein (hFABP) in acute heart failure - diagnostic and prognostic insights compared to NT-proBNP and troponin I.  BMC Cardiovascular Disorders, 15 (50).  pp. 1-12.  ISSN 1471-2261     
relation: https://archiv.ub.uni-heidelberg.de/volltextserver/19376/
rights: info:eu-repo/semantics/openAccess
rights: Please see front page of the work (Sorry, Dublin Core plugin does not recognise license id)
language: eng