<> "The repository administrator has not yet configured an RDF license."^^ . <> . . . "Ischemic biomarker heart-type fatty acid binding protein (hFABP) in acute heart failure - diagnostic and prognostic insights compared to NT-proBNP and troponin I"^^ . "Background: To evaluate diagnostic and long-term prognostic values of hFABP compared to NT-proBNP and troponin I (TnI) in patients presenting to the emergency department (ED) suspected of acute heart failure (AHF). Methods: 401 patients with acute dyspnea or peripheral edema, 122 suffering from AHF, were prospectively enrolled and followed up to 5 years. hFABP combined with NT-proBNP versus NT-proBNP alone was tested for AHF diagnosis. Prognostic value of hFABP versus TnI was evaluated in models predicting all-cause mortality (ACM) and AHF related rehospitalization (AHF-RH) at 1 and 5 years, including 11 conventional risk factors plus NT-proBNP. Results: Additional hFABP measurements improved diagnostic specificity and positive predictive value (PPV) of sole NT-proBNP testing at the cutoff <300 ng/l to “rule out” AHF. Highest hFABP levels (4th quartile) were associated with increased ACM (hazard ratios (HR): 2.1–2.5; p = 0.04) and AHF-RH risk at 5 years (HR 2.8–8.3, p = 0.001). ACM was better characterized in prognostic models including TnI, whereas AHF-RH was better characterized in prognostic models including hFABP. Cox analyses revealed a 2 % increase of ACM risk and 3–7 % increase of AHF-RH risk at 5 years by each unit increase of hFABP of 10 ng/ml. Conclusions: Combining hFABP plus NT-proBNP (<300 ng/l) only improves diagnostic specificity and PPV to rule out AHF. hFABP may improve prognosis for long-term AHF-RH, whereas TnI may improve prognosis for ACM. Trial registration: ClinicalTrials.gov identifier: NCT00143793 . "^^ . "2015" . . "15" . "50" . . "BioMed Central"^^ . . . "BMC Cardiovascular Disorders"^^ . . . "14712261" . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . "Martina"^^ . "Brückmann"^^ . "Martina Brückmann"^^ . . "Ibrahim"^^ . "Akin"^^ . "Ibrahim Akin"^^ . . "Ursula"^^ . "Hoffmann"^^ . "Ursula Hoffmann"^^ . . "Michael"^^ . "Neumaier"^^ . "Michael Neumaier"^^ . . "Parviz"^^ . "Ahmad-Nejad"^^ . "Parviz Ahmad-Nejad"^^ . . "Florian"^^ . "Espeter"^^ . "Florian Espeter"^^ . . "Michael"^^ . "Behnes"^^ . "Michael Behnes"^^ . . "Christel"^^ . "Weiß"^^ . "Christel Weiß"^^ . . "Martin"^^ . "Borggrefe"^^ . "Martin Borggrefe"^^ . . "Siegfried"^^ . "Lang"^^ . "Siegfried Lang"^^ . . . . . . "Ischemic biomarker heart-type fatty acid binding protein (hFABP) in acute heart failure - diagnostic and prognostic insights compared to NT-proBNP and troponin I (PDF)"^^ . . . "12872_2015_Article_26.pdf"^^ . . . "Ischemic biomarker heart-type fatty acid binding protein (hFABP) in acute heart failure - diagnostic and prognostic insights compared to NT-proBNP and troponin I (Other)"^^ . . . . . . "indexcodes.txt"^^ . . . "Ischemic biomarker heart-type fatty acid binding protein (hFABP) in acute heart failure - diagnostic and prognostic insights compared to NT-proBNP and troponin I (Other)"^^ . . . . . . "lightbox.jpg"^^ . . . "Ischemic biomarker heart-type fatty acid binding protein (hFABP) in acute heart failure - diagnostic and prognostic insights compared to NT-proBNP and troponin I (Other)"^^ . . . . . . "preview.jpg"^^ . . . "Ischemic biomarker heart-type fatty acid binding protein (hFABP) in acute heart failure - diagnostic and prognostic insights compared to NT-proBNP and troponin I (Other)"^^ . . . . . . "medium.jpg"^^ . . . "Ischemic biomarker heart-type fatty acid binding protein (hFABP) in acute heart failure - diagnostic and prognostic insights compared to NT-proBNP and troponin I (Other)"^^ . . . . . . "small.jpg"^^ . . "HTML Summary of #19376 \n\nIschemic biomarker heart-type fatty acid binding protein (hFABP) in acute heart failure - diagnostic and prognostic insights compared to NT-proBNP and troponin I\n\n" . "text/html" . . . "610 Medizin"@de . "610 Medical sciences Medicine"@en . .