<> "The repository administrator has not yet configured an RDF license."^^ . <> . . . "p16INK4a/Ki-67 dual stain cytology for cervical cancer screening in Thika district, Kenya"^^ . "Background: The identification of suited early detection tests is one among the multiple requirements to reduce cervical cancer incidence in developing countries. Methods: We evaluated p16INK4a/Ki-67 dual-stain cytology in a screening population in Thika district, Kenya and compared it to high-risk human papillomavirus (HR-HPV) DNA testing and visual inspection by acetic acid (VIA) and Lugol’s iodine (VILI). Results: Valid results for all tests could be obtained in 477 women. 20.9 % (100/477) were tested positive for HR-HPV DNA, 3.1 % (15/477) had positive VIA/VILI and 8.2 % (39/477) positive p16INK4a/Ki-67 cytology. Of 22 women that showed up for colposcopy and biopsy, 6 women were diagnosed with CIN3 and two with CIN2. All women with CIN2/3 were negative in VIA/VILI screening and positive by HR-HPV DNA testing. But HPV was also positive in 91.7 % (11/12) of women with normal histology. p16INK4a/Ki-67 cytology was positive in all 6 women with CIN3, in one of the two CIN2 and in only 8.3 % (1/12) of women with normal histology. Conclusions: p16INK4a/Ki-67 cytology is an interesting test for further studies in developing countries, since our findings point to a lower fraction of false positive test results using p16INK4a/Ki-67 cytology compared to HPV DNA testing in a Kenyan screening population. VIA/VILI missed all histology-proven CIN2/3. "^^ . "2015" . . "10" . "25" . . "BioMed Central"^^ . . . "Infectious agents and cancer"^^ . . . "17509378" . . . . . . . . . . . . . . . . . . . . . . . . . . . . . "Peter"^^ . "Wanzala"^^ . "Peter Wanzala"^^ . . "Caroline"^^ . "Wangari Ngugi"^^ . "Caroline Wangari Ngugi"^^ . . "Hamadi"^^ . "Boga"^^ . "Hamadi Boga"^^ . . "John"^^ . "Mbithi"^^ . "John Mbithi"^^ . . "Dietmar"^^ . "Schmidt"^^ . "Dietmar Schmidt"^^ . . "Miriam"^^ . "Reuschenbach"^^ . "Miriam Reuschenbach"^^ . . "Karanja"^^ . "Wanyoro"^^ . "Karanja Wanyoro"^^ . . "Magnus"^^ . "von Knebel-Doeberitz"^^ . "Magnus von Knebel-Doeberitz"^^ . . "Anne"^^ . "Muigai"^^ . "Anne Muigai"^^ . . . . . . "p16INK4a/Ki-67 dual stain cytology for cervical cancer screening in Thika district, Kenya (PDF)"^^ . . . "13027_2015_Article_20.pdf"^^ . . . "p16INK4a/Ki-67 dual stain cytology for cervical cancer screening in Thika district, Kenya (Other)"^^ . . . . . . "lightbox.jpg"^^ . . . "p16INK4a/Ki-67 dual stain cytology for cervical cancer screening in Thika district, Kenya (Other)"^^ . . . . . . "preview.jpg"^^ . . . "p16INK4a/Ki-67 dual stain cytology for cervical cancer screening in Thika district, Kenya (Other)"^^ . . . . . . "medium.jpg"^^ . . . "p16INK4a/Ki-67 dual stain cytology for cervical cancer screening in Thika district, Kenya (Other)"^^ . . . . . . "small.jpg"^^ . . . "p16INK4a/Ki-67 dual stain cytology for cervical cancer screening in Thika district, Kenya (Other)"^^ . . . . . . "indexcodes.txt"^^ . . "HTML Summary of #19386 \n\np16INK4a/Ki-67 dual stain cytology for cervical cancer screening in Thika district, Kenya\n\n" . "text/html" . . . "570 Biowissenschaften, Biologie"@de . "570 Life sciences"@en . . . "610 Medizin"@de . "610 Medical sciences Medicine"@en . .