eprintid: 19402
rev_number: 15
eprint_status: archive
userid: 1589
dir: disk0/00/01/94/02
datestamp: 2015-12-23 08:22:18
lastmod: 2024-03-11 06:24:56
status_changed: 2015-12-23 08:22:18
type: article
metadata_visibility: show
creators_name: van Zuuren, Esther J.
creators_name: Apfelbacher, Christian J.
creators_name: Fedorowicz, Zbys
creators_name: Jupiter, Aldrin
creators_name: Matterne, Uwe
creators_name: Weisshaar, Elke
title: No high level evidence to support the use of oral H1 antihistamines as monotherapy for eczema: a summary of a Cochrane systematic review
subjects: ddc-610
divisions: i-910100
divisions: i-911300
abstract: Background: The most important symptom as well as one of the major diagnostic criteria for eczema is itch. Although oral antihistamines continue to be prescribed for people with eczema, it is unclear if they are effective and safe in relieving itch and skin lesions. We sought to evaluate the available evidence on effectiveness of oral antihistamines (H1 antagonists) as monotherapy in children and adults with eczema.   Methods: Searches included 10 databases and trial registers as well as conference proceedings (January 2014). Randomised controlled trials that assessed the effects of oral H1 antihistamines as monotherapy in children and adults with eczema were included.   Results: Our searches retrieved 757 references, but no randomised controlled trial met our inclusion criteria. Most studies allowed concomitant treatments, making the assessment of the individual effects of oral H1 antihistamines impossible.   Conclusions: There is currently no high-level evidence to support or refute the efficacy or safety of oral H1 antihistamines used as monotherapy for eczema. A further review of studies that assesses the effects of oral H1 antihistamines as ‘add-on’ therapy together with concomitant treatments is warranted to determine the beneficial effects of this group of medications in the treatment of eczema.  
date: 2014
publisher: BioMed Central
id_scheme: DOI
ppn_swb: 1653681837
own_urn: urn:nbn:de:bsz:16-heidok-194023
language: eng
bibsort: VANZUURENENOHIGHLEVE2014
full_text_status: public
publication: Systematic Reviews
volume: 3
number: 25
place_of_pub: London
pagerange: 1-5
issn: 2046-4053
citation:   van Zuuren, Esther J. ; Apfelbacher, Christian J. ; Fedorowicz, Zbys ; Jupiter, Aldrin ; Matterne, Uwe ; Weisshaar, Elke  (2014) No high level evidence to support the use of oral H1 antihistamines as monotherapy for eczema: a summary of a Cochrane systematic review.  Systematic Reviews, 3 (25).  pp. 1-5.  ISSN 2046-4053     
document_url: https://archiv.ub.uni-heidelberg.de/volltextserver/19402/1/13643_2013_Article_333.pdf