title: High-dose single-fraction IMRT versus fractionated external beam radiotherapy for patients with spinal bone metastases: study protocol for a randomized controlled trial
creator: Rief, Harald
creator: Katayama, Sonja
creator: Bruckner, Thomas
creator: Rieken, Stefan
creator: Bostel, Tilman
creator: Förster, Robert
creator: Schlampp, Ingmar
creator: Wolf, Robert
creator: Debus, Jürgen
creator: Sterzing, Florian
subject: ddc-610
subject: 610 Medical sciences Medicine
description: Background: Stereotactic body radiation therapy (SBRT)using intensity-modulated radiotherapy (IMRT) can be a safe modality for treating spinal bone metastasis with enhanced targeting accuracy and an effective method for achieving good tumor control and a rigorous pain response.   Methods/design: This is a single-center, prospective randomized controlled trial to evaluate pain relief after RT and consists of two treatment groups with 30 patients in each group. One group will receive single-fraction intensity-modulated RT with 1×24 Gy, and the other will receive fractionated RT with 10×3 Gy. The target parameters will be measured at baseline and at 3 and 6 months after RT.   Discussion: The aim of this study is to evaluate pain relief after RT in patients with spinal bone metastases by means of two different techniques: stereotactic body radiation therapy and fractionated RT. The primary endpoint is pain relief at the 3-month time-point after RT. Secondly, quality of life, fatigue, overall and bone survival, and local control will be assessed.   Trial registration ClinicalTrials.gov identifier NCT02358720  (June 2, 2015).  
publisher: BioMed Central
date: 2015
type: Article
type: info:eu-repo/semantics/article
type: NonPeerReviewed
format: application/pdf
identifier: https://archiv.ub.uni-heidelberg.de/volltextserverhttps://archiv.ub.uni-heidelberg.de/volltextserver/19405/1/13063_2015_Article_761.pdf
identifier: DOI:
identifier: urn:nbn:de:bsz:16-heidok-194053
identifier:   Rief, Harald ; Katayama, Sonja ; Bruckner, Thomas ; Rieken, Stefan ; Bostel, Tilman ; Förster, Robert ; Schlampp, Ingmar ; Wolf, Robert ; Debus, Jürgen ; Sterzing, Florian  (2015) High-dose single-fraction IMRT versus fractionated external beam radiotherapy for patients with spinal bone metastases: study protocol for a randomized controlled trial.  Trials, 16 (264).  pp. 1-5.  ISSN 1468-6694     
relation: https://archiv.ub.uni-heidelberg.de/volltextserver/19405/
rights: info:eu-repo/semantics/openAccess
rights: Please see front page of the work (Sorry, Dublin Core plugin does not recognise license id)
language: eng