TY  - JOUR
AV  - public
SN  - 1468-6694
Y1  - 2015///
TI  - High-dose single-fraction IMRT versus fractionated external beam radiotherapy for patients with spinal bone metastases: study protocol for a randomized controlled trial
JF  - Trials
ID  - heidok19405
VL  - 16
SP  - 1
N2  - Background: Stereotactic body radiation therapy (SBRT)using intensity-modulated radiotherapy (IMRT) can be a safe modality for treating spinal bone metastasis with enhanced targeting accuracy and an effective method for achieving good tumor control and a rigorous pain response.   Methods/design: This is a single-center, prospective randomized controlled trial to evaluate pain relief after RT and consists of two treatment groups with 30 patients in each group. One group will receive single-fraction intensity-modulated RT with 1×24 Gy, and the other will receive fractionated RT with 10×3 Gy. The target parameters will be measured at baseline and at 3 and 6 months after RT.   Discussion: The aim of this study is to evaluate pain relief after RT in patients with spinal bone metastases by means of two different techniques: stereotactic body radiation therapy and fractionated RT. The primary endpoint is pain relief at the 3-month time-point after RT. Secondly, quality of life, fatigue, overall and bone survival, and local control will be assessed.   Trial registration ClinicalTrials.gov identifier NCT02358720  (June 2, 2015).  
PB  - BioMed Central
EP  - 5
CY  - London
IS  - 264
UR  - https://archiv.ub.uni-heidelberg.de/volltextserver/19405/
A1  - Rief, Harald
A1  - Katayama, Sonja
A1  - Bruckner, Thomas
A1  - Rieken, Stefan
A1  - Bostel, Tilman
A1  - Förster, Robert
A1  - Schlampp, Ingmar
A1  - Wolf, Robert
A1  - Debus, Jürgen
A1  - Sterzing, Florian
ER  -