eprintid: 19405
rev_number: 15
eprint_status: archive
userid: 1589
dir: disk0/00/01/94/05
datestamp: 2015-12-15 10:34:57
lastmod: 2024-03-15 16:28:02
status_changed: 2015-12-15 10:34:57
type: article
metadata_visibility: show
creators_name: Rief, Harald
creators_name: Katayama, Sonja
creators_name: Bruckner, Thomas
creators_name: Rieken, Stefan
creators_name: Bostel, Tilman
creators_name: Förster, Robert
creators_name: Schlampp, Ingmar
creators_name: Wolf, Robert
creators_name: Debus, Jürgen
creators_name: Sterzing, Florian
title: High-dose single-fraction IMRT versus fractionated external beam radiotherapy for patients with spinal bone metastases: study protocol for a randomized controlled trial
subjects: ddc-610
divisions: i-911400
divisions: i-911800
abstract: Background: Stereotactic body radiation therapy (SBRT)using intensity-modulated radiotherapy (IMRT) can be a safe modality for treating spinal bone metastasis with enhanced targeting accuracy and an effective method for achieving good tumor control and a rigorous pain response.   Methods/design: This is a single-center, prospective randomized controlled trial to evaluate pain relief after RT and consists of two treatment groups with 30 patients in each group. One group will receive single-fraction intensity-modulated RT with 1×24 Gy, and the other will receive fractionated RT with 10×3 Gy. The target parameters will be measured at baseline and at 3 and 6 months after RT.   Discussion: The aim of this study is to evaluate pain relief after RT in patients with spinal bone metastases by means of two different techniques: stereotactic body radiation therapy and fractionated RT. The primary endpoint is pain relief at the 3-month time-point after RT. Secondly, quality of life, fatigue, overall and bone survival, and local control will be assessed.   Trial registration ClinicalTrials.gov identifier NCT02358720  (June 2, 2015).  
date: 2015
publisher: BioMed Central
id_scheme: DOI
ppn_swb: 1655191160
own_urn: urn:nbn:de:bsz:16-heidok-194053
language: eng
bibsort: RIEFHARALDHIGHDOSESI2015
full_text_status: public
publication: Trials
volume: 16
number: 264
place_of_pub: London
pagerange: 1-5
issn: 1468-6694
citation:   Rief, Harald ; Katayama, Sonja ; Bruckner, Thomas ; Rieken, Stefan ; Bostel, Tilman ; Förster, Robert ; Schlampp, Ingmar ; Wolf, Robert ; Debus, Jürgen ; Sterzing, Florian  (2015) High-dose single-fraction IMRT versus fractionated external beam radiotherapy for patients with spinal bone metastases: study protocol for a randomized controlled trial.  Trials, 16 (264).  pp. 1-5.  ISSN 1468-6694     
document_url: https://archiv.ub.uni-heidelberg.de/volltextserver/19405/1/13063_2015_Article_761.pdf