title:  Primary and secondary angiosarcomas: a comparative single-center analysis
creator: Hillenbrand, Thorsten
creator: Menge, Franka
creator: Hohenberger, Peter
creator: Kasper, Bernd
subject: 610
subject: 610 Medical sciences Medicine
description: Background: Angiosarcomas (AS) are rare vascular malignancies. They are subdivided into primary (PAS) and secondary angiosarcomas (SAS). The objective was to compare the characteristics of AS subtypes.   Methods: Eighteen PAS and ten SAS patients treated at our institution between 2004 and 2012 were included in this study.   Results: Median age of PAS and SAS patients was 52.9 and 64.2 years, respectively (p = 0.1448). The percentage of women was 27.8% for PAS, but 80.0% for SAS (p = 0.0163). While PAS occurred throughout the body, the majority of SAS arose from the breast (p = 0.0012). All SAS were radiation-induced with a median latency of 7.7 years. The majority of patients with PAS and SAS underwent surgery as primary or recurrence treatment (p > 0.95). Local recurrence was developed by 27.8% of PAS and 50.0% of SAS (p = 0.4119). 61.1% of PAS metastasized, but only 40.0% of SAS (p = 0.4328). Median overall survival for PAS and SAS was 19 and 57 months, respectively (p = 0.2306).   Conclusion: Radical surgery remains the mainstay of both primary and recurrence treatment. SAS show a high local recurrence rate, while PAS tend towards developing early metastases. Overall, prognosis is poor for both groups.  
publisher: BioMed Central
date: 2015
type: Article
type: info:eu-repo/semantics/article
type: NonPeerReviewed
format: application/pdf
identifier: https://archiv.ub.uni-heidelberg.de/volltextserverhttps://archiv.ub.uni-heidelberg.de/volltextserver/19417/1/13569_2015_Article_28.pdf
identifier: DOI:
identifier: urn:nbn:de:bsz:16-heidok-194175
identifier:   Hillenbrand, Thorsten ; Menge, Franka ; Hohenberger, Peter ; Kasper, Bernd  (2015)  Primary and secondary angiosarcomas: a comparative single-center analysis.  Clinical Sarcoma Research, 5 (14).  pp. 1-7.  ISSN 2045-3329     
relation: https://archiv.ub.uni-heidelberg.de/volltextserver/19417/
rights: info:eu-repo/semantics/openAccess
rights: Please see front page of the work (Sorry, Dublin Core plugin does not recognise license id)
language: eng