%0 Journal Article
%@ 2045-3329
%A Hillenbrand, Thorsten
%A Menge, Franka
%A Hohenberger, Peter
%A Kasper, Bernd
%C London
%D 2015
%F heidok:19417
%I BioMed Central
%J Clinical Sarcoma Research
%N 14
%P 1-7
%T  Primary and secondary angiosarcomas: a comparative single-center analysis
%U https://archiv.ub.uni-heidelberg.de/volltextserver/19417/
%V 5
%X Background: Angiosarcomas (AS) are rare vascular malignancies. They are subdivided into primary (PAS) and secondary angiosarcomas (SAS). The objective was to compare the characteristics of AS subtypes.   Methods: Eighteen PAS and ten SAS patients treated at our institution between 2004 and 2012 were included in this study.   Results: Median age of PAS and SAS patients was 52.9 and 64.2 years, respectively (p = 0.1448). The percentage of women was 27.8% for PAS, but 80.0% for SAS (p = 0.0163). While PAS occurred throughout the body, the majority of SAS arose from the breast (p = 0.0012). All SAS were radiation-induced with a median latency of 7.7 years. The majority of patients with PAS and SAS underwent surgery as primary or recurrence treatment (p > 0.95). Local recurrence was developed by 27.8% of PAS and 50.0% of SAS (p = 0.4119). 61.1% of PAS metastasized, but only 40.0% of SAS (p = 0.4328). Median overall survival for PAS and SAS was 19 and 57 months, respectively (p = 0.2306).   Conclusion: Radical surgery remains the mainstay of both primary and recurrence treatment. SAS show a high local recurrence rate, while PAS tend towards developing early metastases. Overall, prognosis is poor for both groups.