TY  - JOUR
A1  - Hillenbrand, Thorsten
A1  - Menge, Franka
A1  - Hohenberger, Peter
A1  - Kasper, Bernd
CY  - London
UR  - https://archiv.ub.uni-heidelberg.de/volltextserver/19417/
N2  - Background: Angiosarcomas (AS) are rare vascular malignancies. They are subdivided into primary (PAS) and secondary angiosarcomas (SAS). The objective was to compare the characteristics of AS subtypes.   Methods: Eighteen PAS and ten SAS patients treated at our institution between 2004 and 2012 were included in this study.   Results: Median age of PAS and SAS patients was 52.9 and 64.2 years, respectively (p = 0.1448). The percentage of women was 27.8% for PAS, but 80.0% for SAS (p = 0.0163). While PAS occurred throughout the body, the majority of SAS arose from the breast (p = 0.0012). All SAS were radiation-induced with a median latency of 7.7 years. The majority of patients with PAS and SAS underwent surgery as primary or recurrence treatment (p > 0.95). Local recurrence was developed by 27.8% of PAS and 50.0% of SAS (p = 0.4119). 61.1% of PAS metastasized, but only 40.0% of SAS (p = 0.4328). Median overall survival for PAS and SAS was 19 and 57 months, respectively (p = 0.2306).   Conclusion: Radical surgery remains the mainstay of both primary and recurrence treatment. SAS show a high local recurrence rate, while PAS tend towards developing early metastases. Overall, prognosis is poor for both groups.  
IS  - 14
Y1  - 2015///
SN  - 2045-3329
VL  - 5
EP  - 7
PB  - BioMed Central
TI  -  Primary and secondary angiosarcomas: a comparative single-center analysis
SP  - 1
JF  - Clinical Sarcoma Research
ID  - heidok19417
AV  - public
ER  -