eprintid: 19417
rev_number: 15
eprint_status: archive
userid: 1589
dir: disk0/00/01/94/17
datestamp: 2015-12-22 09:50:04
lastmod: 2024-03-10 08:55:47
status_changed: 2015-12-22 09:50:04
type: article
metadata_visibility: show
creators_name: Hillenbrand, Thorsten
creators_name: Menge, Franka
creators_name: Hohenberger, Peter
creators_name: Kasper, Bernd
title:  Primary and secondary angiosarcomas: a comparative single-center analysis
subjects: 610
divisions: 61200
divisions: 62400
abstract: Background: Angiosarcomas (AS) are rare vascular malignancies. They are subdivided into primary (PAS) and secondary angiosarcomas (SAS). The objective was to compare the characteristics of AS subtypes.   Methods: Eighteen PAS and ten SAS patients treated at our institution between 2004 and 2012 were included in this study.   Results: Median age of PAS and SAS patients was 52.9 and 64.2 years, respectively (p = 0.1448). The percentage of women was 27.8% for PAS, but 80.0% for SAS (p = 0.0163). While PAS occurred throughout the body, the majority of SAS arose from the breast (p = 0.0012). All SAS were radiation-induced with a median latency of 7.7 years. The majority of patients with PAS and SAS underwent surgery as primary or recurrence treatment (p > 0.95). Local recurrence was developed by 27.8% of PAS and 50.0% of SAS (p = 0.4119). 61.1% of PAS metastasized, but only 40.0% of SAS (p = 0.4328). Median overall survival for PAS and SAS was 19 and 57 months, respectively (p = 0.2306).   Conclusion: Radical surgery remains the mainstay of both primary and recurrence treatment. SAS show a high local recurrence rate, while PAS tend towards developing early metastases. Overall, prognosis is poor for both groups.  
date: 2015
publisher: BioMed Central
id_scheme: DOI
ppn_swb: 1653700483
own_urn: urn:nbn:de:bsz:16-heidok-194175
language: eng
bibsort: HILLENBRANPRIMARYAND2015
full_text_status: public
publication: Clinical Sarcoma Research
volume: 5
number: 14
place_of_pub: London
pagerange: 1-7
issn: 2045-3329
citation:   Hillenbrand, Thorsten ; Menge, Franka ; Hohenberger, Peter ; Kasper, Bernd  (2015)  Primary and secondary angiosarcomas: a comparative single-center analysis.  Clinical Sarcoma Research, 5 (14).  pp. 1-7.  ISSN 2045-3329     
document_url: https://archiv.ub.uni-heidelberg.de/volltextserver/19417/1/13569_2015_Article_28.pdf