title: Clinical outcome of hypofractionated breath-hold image-guided SABR of primary lung tumors and lung metastases
creator: Boda-Heggemann, Judit
creator: Frauenfeld, Anian
creator: Weiss, Christel
creator: Simeonova, Anna
creator: Neumaier, Christian
creator: Siebenlist, Kerstin
creator: Attenberger, Ulrike
creator: Heußel, Claus Peter
creator: Schneider, Frank
creator: Wenz, Frederik
creator: Lohr, Frank
subject: ddc-610
subject: 610 Medical sciences Medicine
description: Background: Stereotactic Ablative RadioTherapy (SABR) of lung tumors/metastases has been shown to be an effective treatment modality with low toxicity. Outcome and toxicity were retrospectively evaluated in a unique single-institution cohort treated with intensity-modulated image-guided breath-hold SABR (igSABR) without external immobilization. The dose–response relationship is analyzed based on Biologically Equivalent Dose (BED).   Patients and methods: 50 lesions in 43 patients with primary NSCLC (n = 27) or lung-metastases of various primaries (n = 16) were consecutively treated with igSABR with Active-Breathing-Coordinator (ABC®) and repeat-breath-hold cone-beam-CT. After an initial dose-finding/-escalation period, 5x12 Gy for peripheral lesions and single doses of 5 Gy to varying dose levels for central lesions were applied. Overall-survival (OS), progression-free-survival (PFS), progression pattern, local control (LC) and toxicity were analyzed.   Results: The median BED2 was 83 Gy. 12 lesions were treated with a BED2 of &lt;80 Gy, and 38 lesions with a BED2 of <80 Gy. Median follow-up was 15 months. Actuarial 1- and 2-year OS were 67% and 43%; respectively. Cause of death was non-disease-related in 27%. Actuarial 1- and 2-year PFS was 42% and 28%. Progression site was predominantly distant. Actuarial 1- and 2 year LC was 90% and 85%. LC showed a trend for a correlation to BED2 (p = 0.1167). Pneumonitis requiring conservative treatment occurred in 23%.   Conclusion: Intensity-modulated breath-hold igSABR results in high LC-rates and low toxicity in this unfavorable patient cohort with inoperable lung tumors or metastases. A BED2 of <80 Gy was associated with reduced local control.
publisher: BioMed Central
date: 2014
type: Article
type: info:eu-repo/semantics/article
type: NonPeerReviewed
format: application/pdf
identifier: https://archiv.ub.uni-heidelberg.de/volltextserverhttps://archiv.ub.uni-heidelberg.de/volltextserver/19425/1/13014_2013_Article_1211.pdf
identifier: DOI:
identifier: urn:nbn:de:bsz:16-heidok-194251
identifier:   Boda-Heggemann, Judit ; Frauenfeld, Anian ; Weiss, Christel ; Simeonova, Anna ; Neumaier, Christian ; Siebenlist, Kerstin ; Attenberger, Ulrike ; Heußel, Claus Peter ; Schneider, Frank ; Wenz, Frederik ; Lohr, Frank  (2014) Clinical outcome of hypofractionated breath-hold image-guided SABR of primary lung tumors and lung metastases.  Radiation Oncology, 9 (10).  pp. 1-9.  ISSN 1748-717X     
relation: https://archiv.ub.uni-heidelberg.de/volltextserver/19425/
rights: info:eu-repo/semantics/openAccess
rights: Please see front page of the work (Sorry, Dublin Core plugin does not recognise license id)
language: eng