<> "The repository administrator has not yet configured an RDF license."^^ . <> . . . "Clinical outcome of hypofractionated breath-hold image-guided SABR of primary lung tumors and lung metastases"^^ . "Background: Stereotactic Ablative RadioTherapy (SABR) of lung tumors/metastases has been shown to be an effective treatment modality with low toxicity. Outcome and toxicity were retrospectively evaluated in a unique single-institution cohort treated with intensity-modulated image-guided breath-hold SABR (igSABR) without external immobilization. The dose–response relationship is analyzed based on Biologically Equivalent Dose (BED). Patients and methods: 50 lesions in 43 patients with primary NSCLC (n = 27) or lung-metastases of various primaries (n = 16) were consecutively treated with igSABR with Active-Breathing-Coordinator (ABC®) and repeat-breath-hold cone-beam-CT. After an initial dose-finding/-escalation period, 5x12 Gy for peripheral lesions and single doses of 5 Gy to varying dose levels for central lesions were applied. Overall-survival (OS), progression-free-survival (PFS), progression pattern, local control (LC) and toxicity were analyzed. Results: The median BED2 was 83 Gy. 12 lesions were treated with a BED2 of <80 Gy, and 38 lesions with a BED2 of <80 Gy. Median follow-up was 15 months. Actuarial 1- and 2-year OS were 67% and 43%; respectively. Cause of death was non-disease-related in 27%. Actuarial 1- and 2-year PFS was 42% and 28%. Progression site was predominantly distant. Actuarial 1- and 2 year LC was 90% and 85%. LC showed a trend for a correlation to BED2 (p = 0.1167). Pneumonitis requiring conservative treatment occurred in 23%. Conclusion: Intensity-modulated breath-hold igSABR results in high LC-rates and low toxicity in this unfavorable patient cohort with inoperable lung tumors or metastases. A BED2 of <80 Gy was associated with reduced local control. "^^ . "2014" . . "9" . "10" . . "BioMed Central"^^ . . . "Radiation Oncology"^^ . . . "1748717X" . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . "Frank"^^ . "Schneider"^^ . "Frank Schneider"^^ . . "Frederik"^^ . "Wenz"^^ . "Frederik Wenz"^^ . . "Claus Peter"^^ . "Heußel"^^ . "Claus Peter Heußel"^^ . . "Anna"^^ . "Simeonova"^^ . "Anna Simeonova"^^ . . "Frank"^^ . "Lohr"^^ . "Frank Lohr"^^ . . "Ulrike"^^ . "Attenberger"^^ . "Ulrike Attenberger"^^ . . "Christian"^^ . "Neumaier"^^ . "Christian Neumaier"^^ . . "Kerstin"^^ . "Siebenlist"^^ . "Kerstin Siebenlist"^^ . . "Judit"^^ . "Boda-Heggemann"^^ . "Judit Boda-Heggemann"^^ . . "Christel"^^ . "Weiss"^^ . "Christel Weiss"^^ . . "Anian"^^ . "Frauenfeld"^^ . "Anian Frauenfeld"^^ . . . . . . "Clinical outcome of hypofractionated breath-hold image-guided SABR of primary lung tumors and lung metastases (PDF)"^^ . . . "13014_2013_Article_1211.pdf"^^ . . . "Clinical outcome of hypofractionated breath-hold image-guided SABR of primary lung tumors and lung metastases (Other)"^^ . . . . . . "indexcodes.txt"^^ . . . "Clinical outcome of hypofractionated breath-hold image-guided SABR of primary lung tumors and lung metastases (Other)"^^ . . . . . . "lightbox.jpg"^^ . . . "Clinical outcome of hypofractionated breath-hold image-guided SABR of primary lung tumors and lung metastases (Other)"^^ . . . . . . "preview.jpg"^^ . . . "Clinical outcome of hypofractionated breath-hold image-guided SABR of primary lung tumors and lung metastases (Other)"^^ . . . . . . "medium.jpg"^^ . . . "Clinical outcome of hypofractionated breath-hold image-guided SABR of primary lung tumors and lung metastases (Other)"^^ . . . . . . "small.jpg"^^ . . "HTML Summary of #19425 \n\nClinical outcome of hypofractionated breath-hold image-guided SABR of primary lung tumors and lung metastases\n\n" . "text/html" . . . "610 Medizin"@de . "610 Medical sciences Medicine"@en . .