TY - JOUR N2 - Background: Stereotactic Ablative RadioTherapy (SABR) of lung tumors/metastases has been shown to be an effective treatment modality with low toxicity. Outcome and toxicity were retrospectively evaluated in a unique single-institution cohort treated with intensity-modulated image-guided breath-hold SABR (igSABR) without external immobilization. The dose?response relationship is analyzed based on Biologically Equivalent Dose (BED). Patients and methods: 50 lesions in 43 patients with primary NSCLC (n?=?27) or lung-metastases of various primaries (n?=?16) were consecutively treated with igSABR with Active-Breathing-Coordinator (ABC®) and repeat-breath-hold cone-beam-CT. After an initial dose-finding/-escalation period, 5x12?Gy for peripheral lesions and single doses of 5?Gy to varying dose levels for central lesions were applied. Overall-survival (OS), progression-free-survival (PFS), progression pattern, local control (LC) and toxicity were analyzed. Results: The median BED2 was 83?Gy. 12 lesions were treated with a BED2 of <80?Gy, and 38 lesions with a BED2 of <80?Gy. Median follow-up was 15 months. Actuarial 1- and 2-year OS were 67% and 43%; respectively. Cause of death was non-disease-related in 27%. Actuarial 1- and 2-year PFS was 42% and 28%. Progression site was predominantly distant. Actuarial 1- and 2?year LC was 90% and 85%. LC showed a trend for a correlation to BED2 (p?=?0.1167). Pneumonitis requiring conservative treatment occurred in 23%. Conclusion: Intensity-modulated breath-hold igSABR results in high LC-rates and low toxicity in this unfavorable patient cohort with inoperable lung tumors or metastases. A BED2 of <80?Gy was associated with reduced local control. PB - BioMed Central SN - 1748-717X UR - https://archiv.ub.uni-heidelberg.de/volltextserver/19425/ IS - 10 A1 - Boda-Heggemann, Judit A1 - Frauenfeld, Anian A1 - Weiss, Christel A1 - Simeonova, Anna A1 - Neumaier, Christian A1 - Siebenlist, Kerstin A1 - Attenberger, Ulrike A1 - Heußel, Claus Peter A1 - Schneider, Frank A1 - Wenz, Frederik A1 - Lohr, Frank EP - 9 JF - Radiation Oncology ID - heidok19425 SP - 1 VL - 9 TI - Clinical outcome of hypofractionated breath-hold image-guided SABR of primary lung tumors and lung metastases Y1 - 2014/// AV - public CY - London ER -