title: Population-based SEER trend analysis of overall and cancer-specific survival in 5138 patients with gastrointestinal stromal tumor
creator: Güller, Ulrich
creator: Tarantino, Ignazio
creator: Cerny, Thomas
creator: Schmied, Bruno M.
creator: Warschkow, Rene
subject: ddc-610
subject: 610 Medical sciences Medicine
description: Background: The objective of the present population-based analysis was to assess survival patterns in patients with resected and metastatic GIST.   Methods: Patients with histologically proven GIST were extracted from the Surveillance, Epidemiology and End Results (SEER) database from 1998 through 2011. Survival was determined applying Kaplan-Meier-estimates and multivariable Cox-regression analyses. The impact of size and mitotic count on survival was assessed with a generalized receiver-operating characteristic-analysis.   Results: Overall, 5138 patients were included. Median age was 62 years (range: 18–101 years), 47.3% were female, 68.8% Caucasians. GIST location was in the stomach in 58.7% and small bowel in 31.2%. Lymph node and distant metastases were found in 5.1 and 18.0%, respectively. For non-metastatic GIST, three-year overall survival increased from 68.5% (95% CI: 58.8–79.8%) in 1998 to 88.6% (95% CI: 85.3–92.0%) in 2008, cancer-specific survival from 75.3% (95% CI: 66.1–85.9%) in 1998 to 92.2% (95% CI: 89.4–95.1%) in 2008. For metastatic GIST, three-year overall survival increased from 15.0% (95% CI: 5.3–42.6%) in 1998 to 54.7% (95% CI: 44.4–67.3%) in 2008, cancer-specific survival from 15.0% (95% CI: 5.3–42.6%) in 1998 to 61.9% (95% CI: 51.4–74.5%) in 2008 (all PTrend < 0.05).   Conclusions: This is the first SEER trend analysis assessing outcomes in a large cohort of GIST patients over a 11-year time period. The analysis provides compelling evidence of a statistically significant and clinically relevant increase in overall and cancer-specific survival from 1998 to 2008, both for resected as well as metastatic GIST.  
publisher: BioMed Central
date: 2015
type: Article
type: info:eu-repo/semantics/article
type: NonPeerReviewed
format: application/pdf
identifier: https://archiv.ub.uni-heidelberg.de/volltextserverhttps://archiv.ub.uni-heidelberg.de/volltextserver/19441/1/12885_2015_Article_1554.pdf
identifier: DOI:
identifier: urn:nbn:de:bsz:16-heidok-194419
identifier:   Güller, Ulrich ; Tarantino, Ignazio ; Cerny, Thomas ; Schmied, Bruno M. ; Warschkow, Rene  (2015) Population-based SEER trend analysis of overall and cancer-specific survival in 5138 patients with gastrointestinal stromal tumor.  BMC cancer, 15 (557).  pp. 1-11.  ISSN 1471-2407     
relation: https://archiv.ub.uni-heidelberg.de/volltextserver/19441/
rights: info:eu-repo/semantics/openAccess
rights: Please see front page of the work (Sorry, Dublin Core plugin does not recognise license id)
language: eng