title: So rare we need to hunt for them: reframing the ethical debate on incidental findings
creator: Schuol, Sebastian
creator: Schickhardt, Christoph
creator: Wiemann, Stefan
creator: Bartram, Claus R.
creator: Tanner, Klaus
creator: Eils, Roland
creator: Meder, Benjamin
creator: Richter, Daniela
creator: Glimm, Hanno
creator: von Kalle, Christof
creator: Winkler, Eva C.
subject: ddc-200
subject: 200 Religion
subject: ddc-570
subject: 570 Life sciences
subject: ddc-610
subject: 610 Medical sciences Medicine
description: Incidental findings are the subject of intense ethical debate in medical genomic research. Every human genome contains a number of potentially disease-causing alterations that may be detected during comprehensive genetic analyses to investigate a specific condition. Yet available evidence shows that the frequency of incidental findings in research is much lower than expected. In this Opinion, we argue that the reason for the low level of incidental findings is that the filtering techniques and methods that are applied during the routine handling of genomic data remove these alterations. As incidental findings are systematically filtered out, it is now time to evaluate whether the ethical debate is focused on the right issues. We conclude that the key question is whether to deliberately target and search for disease-causing variations outside the indication that has originally led to the genetic analysis, for instance by using positive lists and algorithms.
publisher: BioMed Central
date: 2015
type: Article
type: info:eu-repo/semantics/article
type: NonPeerReviewed
format: application/pdf
identifier: https://archiv.ub.uni-heidelberg.de/volltextserverhttps://archiv.ub.uni-heidelberg.de/volltextserver/19448/1/13073_2015_Article_198.pdf
identifier: DOI:
identifier: urn:nbn:de:bsz:16-heidok-194480
identifier:   Schuol, Sebastian ; Schickhardt, Christoph ; Wiemann, Stefan ; Bartram, Claus R. ; Tanner, Klaus ; Eils, Roland ; Meder, Benjamin ; Richter, Daniela ; Glimm, Hanno ; von Kalle, Christof ; Winkler, Eva C.  (2015) So rare we need to hunt for them: reframing the ethical debate on incidental findings.  Genome Medicine, 7 (83).  pp. 1-7.  ISSN 1756-994X     
relation: https://archiv.ub.uni-heidelberg.de/volltextserver/19448/
rights: info:eu-repo/semantics/openAccess
rights: Please see front page of the work (Sorry, Dublin Core plugin does not recognise license id)
language: eng