TY  - JOUR
IS  - 83
TI  - So rare we need to hunt for them: reframing the ethical debate on incidental findings
SP  - 1
A1  - Schuol, Sebastian
A1  - Schickhardt, Christoph
A1  - Wiemann, Stefan
A1  - Bartram, Claus R.
A1  - Tanner, Klaus
A1  - Eils, Roland
A1  - Meder, Benjamin
A1  - Richter, Daniela
A1  - Glimm, Hanno
A1  - von Kalle, Christof
A1  - Winkler, Eva C.
PB  - BioMed Central
JF  - Genome Medicine
SN  - 1756-994X
ID  - heidok19448
UR  - https://archiv.ub.uni-heidelberg.de/volltextserver/19448/
Y1  - 2015///
EP  - 7
AV  - public
CY  - London
VL  - 7
N2  - Incidental findings are the subject of intense ethical debate in medical genomic research. Every human genome contains a number of potentially disease-causing alterations that may be detected during comprehensive genetic analyses to investigate a specific condition. Yet available evidence shows that the frequency of incidental findings in research is much lower than expected. In this Opinion, we argue that the reason for the low level of incidental findings is that the filtering techniques and methods that are applied during the routine handling of genomic data remove these alterations. As incidental findings are systematically filtered out, it is now time to evaluate whether the ethical debate is focused on the right issues. We conclude that the key question is whether to deliberately target and search for disease-causing variations outside the indication that has originally led to the genetic analysis, for instance by using positive lists and algorithms.
ER  -