eprintid: 19448
rev_number: 22
eprint_status: archive
userid: 1589
dir: disk0/00/01/94/48
datestamp: 2016-01-12 14:34:38
lastmod: 2024-05-01 14:20:32
status_changed: 2016-01-12 14:34:38
type: article
metadata_visibility: show
creators_name: Schuol, Sebastian
creators_name: Schickhardt, Christoph
creators_name: Wiemann, Stefan
creators_name: Bartram, Claus R.
creators_name: Tanner, Klaus
creators_name: Eils, Roland
creators_name: Meder, Benjamin
creators_name: Richter, Daniela
creators_name: Glimm, Hanno
creators_name: von Kalle, Christof
creators_name: Winkler, Eva C.
title: So rare we need to hunt for them: reframing the ethical debate on incidental findings
subjects: 200
subjects: 570
subjects: 610
divisions: 10200
divisions: 160100
divisions: 850300
divisions: 910100
divisions: 911500
abstract: Incidental findings are the subject of intense ethical debate in medical genomic research. Every human genome contains a number of potentially disease-causing alterations that may be detected during comprehensive genetic analyses to investigate a specific condition. Yet available evidence shows that the frequency of incidental findings in research is much lower than expected. In this Opinion, we argue that the reason for the low level of incidental findings is that the filtering techniques and methods that are applied during the routine handling of genomic data remove these alterations. As incidental findings are systematically filtered out, it is now time to evaluate whether the ethical debate is focused on the right issues. We conclude that the key question is whether to deliberately target and search for disease-causing variations outside the indication that has originally led to the genetic analysis, for instance by using positive lists and algorithms.
date: 2015
publisher: BioMed Central
id_scheme: DOI
ppn_swb: 1656477246
own_urn: urn:nbn:de:bsz:16-heidok-194480
language: eng
bibsort: SCHUOLSEBASORAREWENE2015
full_text_status: public
publication: Genome Medicine
volume: 7
number: 83
place_of_pub: London
pagerange: 1-7
issn: 1756-994X
citation:   Schuol, Sebastian ; Schickhardt, Christoph ; Wiemann, Stefan ; Bartram, Claus R. ; Tanner, Klaus ; Eils, Roland ; Meder, Benjamin ; Richter, Daniela ; Glimm, Hanno ; von Kalle, Christof ; Winkler, Eva C.  (2015) So rare we need to hunt for them: reframing the ethical debate on incidental findings.  Genome Medicine, 7 (83).  pp. 1-7.  ISSN 1756-994X     
document_url: https://archiv.ub.uni-heidelberg.de/volltextserver/19448/1/13073_2015_Article_198.pdf