<> "The repository administrator has not yet configured an RDF license."^^ . <> . . . "Associations of common breast cancer susceptibility alleles with risk of breast cancer subtypes in BRCA1 and BRCA2 mutation carriers"^^ . "Introduction: More than 70 common alleles are known to be involved in breast cancer (BC) susceptibility, and several exhibit significant heterogeneity in their associations with different BC subtypes. Although there are differences in the association patterns between BRCA1 and BRCA2 mutation carriers and the general population for several loci, no study has comprehensively evaluated the associations of all known BC susceptibility alleles with risk of BC subtypes in BRCA1 and BRCA2 carriers. Methods: We used data from 15,252 BRCA1 and 8,211 BRCA2 carriers to analyze the associations between approximately 200,000 genetic variants on the iCOGS array and risk of BC subtypes defined by estrogen receptor (ER), progesterone receptor (PR), human epidermal growth factor receptor 2 (HER2) and triple-negative- (TN) status; morphologic subtypes; histological grade; and nodal involvement. Results: The estimated BC hazard ratios (HRs) for the 74 known BC alleles in BRCA1 carriers exhibited moderate correlations with the corresponding odds ratios from the general population. However, their associations with ER-positive BC in BRCA1 carriers were more consistent with the ER-positive associations in the general population (intraclass correlation (ICC) = 0.61, 95% confidence interval (CI): 0.45 to 0.74), and the same was true when considering ER-negative associations in both groups (ICC = 0.59, 95% CI: 0.42 to 0.72). Similarly, there was strong correlation between the ER-positive associations for BRCA1 and BRCA2 carriers (ICC = 0.67, 95% CI: 0.52 to 0.78), whereas ER-positive associations in any one of the groups were generally inconsistent with ER-negative associations in any of the others. After stratifying by ER status in mutation carriers, additional significant associations were observed. Several previously unreported variants exhibited associations at P <10−6 in the analyses by PR status, HER2 status, TN phenotype, morphologic subtypes, histological grade and nodal involvement. Conclusions: Differences in associations of common BC susceptibility alleles between BRCA1 and BRCA2 carriers and the general population are explained to a large extent by differences in the prevalence of ER-positive and ER-negative tumors. Estimates of the risks associated with these variants based on population-based studies are likely to be applicable to mutation carriers after taking ER status into account, which has implications for risk prediction. "^^ . "2014" . . "16" . "3416" . . "BioMed Central"^^ . . . "Breast cancer research"^^ . . . "1465542X" . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . "Ana"^^ . "Osorio"^^ . "Ana Osorio"^^ . . "Antonis C."^^ . "Antoniou"^^ . "Antonis C. Antoniou"^^ . . "Barbara"^^ . "Wappenschmidt"^^ . "Barbara Wappenschmidt"^^ . . "Catherine M."^^ . "Phelan"^^ . "Catherine M. Phelan"^^ . . "Jan"^^ . "Lubinski"^^ . "Jan Lubinski"^^ . . "Fergus J."^^ . "Couch"^^ . "Fergus J. Couch"^^ . . "Elizabeth J."^^ . "Rensburg"^^ . "Elizabeth J. Rensburg"^^ . . "JL"^^ . "de Lange"^^ . "JL de Lange"^^ . . "Anna M."^^ . "Mulligan"^^ . "Anna M. Mulligan"^^ . . "Simona"^^ . "Agata"^^ . "Simona Agata"^^ . . "Mark T."^^ . "Rogers"^^ . "Mark T. Rogers"^^ . . "Nicolas"^^ . "Sevenet"^^ . "Nicolas Sevenet"^^ . . "Lisa"^^ . "Walker"^^ . "Lisa Walker"^^ . . "Shirley"^^ . "Hodgson"^^ . "Shirley Hodgson"^^ . . "Siranoush"^^ . "Manoukian"^^ . "Siranoush Manoukian"^^ . . "Fiona"^^ . "Douglas"^^ . "Fiona Douglas"^^ . . "Carolien H."^^ . "Deurzen"^^ . "Carolien H. Deurzen"^^ . . "Virginie"^^ . "Caux-Moncoutier"^^ . "Virginie Caux-Moncoutier"^^ . . "Nadine"^^ . "Tung"^^ . "Nadine Tung"^^ . . "Bruno"^^ . "Buecher"^^ . "Bruno Buecher"^^ . . "Isaac"^^ . "Tafur"^^ . "Isaac Tafur"^^ . . "Karoline B."^^ . "Kuchenbäcker"^^ . "Karoline B. Kuchenbäcker"^^ . . "Melissa"^^ . "Southey"^^ . "Melissa Southey"^^ . . "Bernard"^^ . "Peissel"^^ . "Bernard Peissel"^^ . . "Nina"^^ . "Ditsch"^^ . "Nina Ditsch"^^ . . "Norbert"^^ . "Arnold"^^ . "Norbert Arnold"^^ . . "Andrew K."^^ . "Godwin"^^ . "Andrew K. Godwin"^^ . . "Mads"^^ . "Thomassen"^^ . "Mads Thomassen"^^ . . "Hansjoerg"^^ . "Plendl"^^ . "Hansjoerg Plendl"^^ . . "Susan"^^ . "Slager"^^ . "Susan Slager"^^ . . "Curtis"^^ . "Olswold"^^ . "Curtis Olswold"^^ . . "Lesley"^^ . "Andrews"^^ . "Lesley Andrews"^^ . . "Mark H."^^ . "Greene"^^ . "Mark H. Greene"^^ . . "David E."^^ . "Goldgar"^^ . "David E. Goldgar"^^ . . "Johanna"^^ . "Rantala"^^ . "Johanna Rantala"^^ . . "Edith"^^ . "Olah"^^ . "Edith Olah"^^ . . "Paolo"^^ . "Peterlongo"^^ . "Paolo Peterlongo"^^ . . "Penny"^^ . "Soucy"^^ . "Penny Soucy"^^ . . "Julian"^^ . "Adlard"^^ . "Julian Adlard"^^ . . "Sara"^^ . "Volorio"^^ . "Sara Volorio"^^ . . "Jeffrey N."^^ . "Weitzel"^^ . "Jeffrey N. Weitzel"^^ . . "Angela"^^ . "Brady"^^ . "Angela Brady"^^ . . "Claudine"^^ . "Isaacs"^^ . "Claudine Isaacs"^^ . . "Florentia"^^ . "Fostira"^^ . "Florentia Fostira"^^ . . "Lucy E."^^ . "Side"^^ . "Lucy E. Side"^^ . . "Frans B."^^ . "Hogervorst"^^ . "Frans B. Hogervorst"^^ . . "Trinidad"^^ . "Caldes"^^ . "Trinidad Caldes"^^ . . "Georgia"^^ . "Chenevix-Trench"^^ . "Georgia Chenevix-Trench"^^ . . "Olufunmilayo I."^^ . "Olopade"^^ . "Olufunmilayo I. Olopade"^^ . . "Fabienne"^^ . "Prieur"^^ . "Fabienne Prieur"^^ . . "Andreas"^^ . "Berger"^^ . "Andreas Berger"^^ . . "Joseph"^^ . "Vijai"^^ . "Joseph Vijai"^^ . . "Daphne"^^ . "Gschwantler Kaulich"^^ . "Daphne Gschwantler Kaulich"^^ . . "Jackie"^^ . "Cook"^^ . "Jackie Cook"^^ . . "Shan"^^ . "Gohrke"^^ . "Shan Gohrke"^^ . . "Orland"^^ . "Diez"^^ . "Orland Diez"^^ . . "Ake"^^ . "Borg"^^ . "Ake Borg"^^ . . "Cecilia M."^^ . "Dorfling"^^ . "Cecilia M. Dorfling"^^ . . "Maria G."^^ . "Tibiletti"^^ . "Maria G. Tibiletti"^^ . . "Miguel"^^ . "de la Hoya"^^ . "Miguel de la Hoya"^^ . . "Amanda E."^^ . "Toland"^^ . "Amanda E. Toland"^^ . . "Vernon S."^^ . "Pankratz"^^ . "Vernon S. Pankratz"^^ . . "Ans M."^^ . "Ouweland"^^ . "Ans M. Ouweland"^^ . . "Susan M."^^ . "Domchek"^^ . "Susan M. Domchek"^^ . . "Carole"^^ . "Brewer"^^ . "Carole Brewer"^^ . . "Lauren"^^ . "Jacobs"^^ . "Lauren Jacobs"^^ . . "Uffe B."^^ . "Jensen"^^ . "Uffe B. Jensen"^^ . . "Irene"^^ . "Konstantopoulou"^^ . "Irene Konstantopoulou"^^ . . "Christoph"^^ . "Engel"^^ . "Christoph Engel"^^ . . "Judy"^^ . "Garber"^^ . "Judy Garber"^^ . . "Conxi"^^ . "Lazaro"^^ . "Conxi Lazaro"^^ . . "Irene L."^^ . "Andrulis"^^ . "Irene L. Andrulis"^^ . . "Douglas F."^^ . "Easton"^^ . "Douglas F. Easton"^^ . . "Mary E."^^ . "Porteous"^^ . "Mary E. Porteous"^^ . . "Linda"^^ . "Steele"^^ . "Linda Steele"^^ . . "Mary B."^^ . "Daly"^^ . "Mary B. Daly"^^ . . "Birgid"^^ . "Markiefka"^^ . "Birgid Markiefka"^^ . . "Alan"^^ . "Donaldson"^^ . "Alan Donaldson"^^ . . "Banu K."^^ . "Arun"^^ . "Banu K. Arun"^^ . . "Raanan"^^ . "Berger"^^ . "Raanan Berger"^^ . . "Paolo"^^ . "Mariani"^^ . "Paolo Mariani"^^ . . "Georg"^^ . "Pfeiler"^^ . "Georg Pfeiler"^^ . . "Marco"^^ . "Montagna"^^ . "Marco Montagna"^^ . . "Mireia"^^ . "Menendez"^^ . "Mireia Menendez"^^ . . "Hans"^^ . "Ehrencrona"^^ . "Hans Ehrencrona"^^ . . "Timothy R."^^ . "Rebbeck"^^ . "Timothy R. Rebbeck"^^ . . "Diana"^^ . "Eccles"^^ . "Diana Eccles"^^ . . "Ilana"^^ . "Cass"^^ . "Ilana Cass"^^ . . "Gord"^^ . "Glendon"^^ . "Gord Glendon"^^ . . "Doris"^^ . "Steinemann"^^ . "Doris Steinemann"^^ . . "Rosemarie"^^ . "Davidson"^^ . "Rosemarie Davidson"^^ . . "Katarzyna"^^ . "Durda"^^ . "Katarzyna Durda"^^ . . "Katarzyna"^^ . "Jaworska-Bieniek"^^ . "Katarzyna Jaworska-Bieniek"^^ . . "Anders"^^ . "Bojesen"^^ . "Anders Bojesen"^^ . . "Mary B."^^ . "Terry"^^ . "Mary B. Terry"^^ . . "Brita"^^ . "Arver"^^ . "Brita Arver"^^ . . "Alex"^^ . "Teulé"^^ . "Alex Teulé"^^ . . "Laura"^^ . "Papi"^^ . "Laura Papi"^^ . . "Jacques"^^ . "Simard"^^ . "Jacques Simard"^^ . . "Thomas"^^ . "Hansen"^^ . "Thomas Hansen"^^ . . "KEP"^^ . "van Roozendaal"^^ . "KEP van Roozendaal"^^ . . "Juul T."^^ . "Wijnen"^^ . "Juul T. Wijnen"^^ . . "Marina"^^ . "Corines"^^ . "Marina Corines"^^ . . "Anne"^^ . "Lincoln"^^ . "Anne Lincoln"^^ . . "Rita K."^^ . "Schmutzler"^^ . "Rita K. Schmutzler"^^ . . "Julian"^^ . "Barwell"^^ . "Julian Barwell"^^ . . "Muy-Kheng"^^ . "Tea"^^ . "Muy-Kheng Tea"^^ . . "Gaia"^^ . "Roversi"^^ . "Gaia Roversi"^^ . . "Cédrick"^^ . "Lefol"^^ . "Cédrick Lefol"^^ . . "Alfons"^^ . "Meindl"^^ . "Alfons Meindl"^^ . . "Joe"^^ . "Dennis"^^ . "Joe Dennis"^^ . . "Yael"^^ . "Laitman"^^ . "Yael Laitman"^^ . . "Dieter"^^ . "Niederacher"^^ . "Dieter Niederacher"^^ . . "Katherine L."^^ . "Nathanson"^^ . "Katherine L. Nathanson"^^ . . "Niklas"^^ . "Loman"^^ . "Niklas Loman"^^ . . "Ute"^^ . "Hamann"^^ . "Ute Hamann"^^ . . "John"^^ . "Hays"^^ . "John Hays"^^ . . "Finn C."^^ . "Nielsen"^^ . "Finn C. Nielsen"^^ . . "Manuel R."^^ . "Teixeira"^^ . "Manuel R. Teixeira"^^ . . "Riccardo"^^ . "Dolcetti"^^ . "Riccardo Dolcetti"^^ . . "Bent"^^ . "Ejlertsen"^^ . "Bent Ejlertsen"^^ . . "Olga M."^^ . "Sinilnikova"^^ . "Olga M. Sinilnikova"^^ . . "Andrew"^^ . "Lee"^^ . "Andrew Lee"^^ . . "Saundra S."^^ . "Buys"^^ . "Saundra S. Buys"^^ . . "Csilla I."^^ . "Szabo"^^ . "Csilla I. Szabo"^^ . . "Marc"^^ . "Tischkowitz"^^ . "Marc Tischkowitz"^^ . . "Mary"^^ . "Hander"^^ . "Mary Hander"^^ . . "Cezary"^^ . "Cybulski"^^ . "Cezary Cybulski"^^ . . "Karin"^^ . "Kast"^^ . "Karin Kast"^^ . . "Giuseppe"^^ . "Giannini"^^ . "Giuseppe Giannini"^^ . . "Annemarie H."^^ . "van der Hout"^^ . "Annemarie H. van der Hout"^^ . . "Daniel"^^ . "Barrowdale"^^ . "Daniel Barrowdale"^^ . . "Patrick J."^^ . "Morrison"^^ . "Patrick J. Morrison"^^ . . "Laure"^^ . "Barjhoux"^^ . "Laure Barjhoux"^^ . . "Christian F."^^ . "Singer"^^ . "Christian F. Singer"^^ . . "Arjen R."^^ . "Mensenkamp"^^ . "Arjen R. Mensenkamp"^^ . . "Xianshu"^^ . "Wang"^^ . "Xianshu Wang"^^ . . "Eitan"^^ . "Friedman"^^ . "Eitan Friedman"^^ . . "Andrea"^^ . "Gehrig"^^ . "Andrea Gehrig"^^ . . "Javier"^^ . "Benitez"^^ . "Javier Benitez"^^ . . "Christian"^^ . "Sutter"^^ . "Christian Sutter"^^ . . "Radka"^^ . "Platte"^^ . "Radka Platte"^^ . . "Anne-Marie"^^ . "Gerdes"^^ . "Anne-Marie Gerdes"^^ . . "Mercedes"^^ . "Duran"^^ . "Mercedes Duran"^^ . . "Marjanka K."^^ . "Schmidt"^^ . "Marjanka K. Schmidt"^^ . . "Susan L."^^ . "Neuhausen"^^ . "Susan L. Neuhausen"^^ . . "Christine"^^ . "Maugard"^^ . "Christine Maugard"^^ . . "Adalgeir"^^ . "Arason"^^ . "Adalgeir Arason"^^ . . "Lesley"^^ . "McGuffog"^^ . "Lesley McGuffog"^^ . . "Valérie"^^ . "Bonadona"^^ . "Valérie Bonadona"^^ . . "Emily"^^ . "Hallberg"^^ . "Emily Hallberg"^^ . . "M. J."^^ . "Kennedy"^^ . "M. J. Kennedy"^^ . . "Liliana"^^ . "Varesco"^^ . "Liliana Varesco"^^ . . "Louise"^^ . "Izatt"^^ . "Louise Izatt"^^ . . "Sofia"^^ . "Khan"^^ . "Sofia Khan"^^ . . "Kenneth"^^ . "Offit"^^ . "Kenneth Offit"^^ . . "Debra"^^ . "Frost"^^ . "Debra Frost"^^ . . "Christine"^^ . "Rappaport"^^ . "Christine Rappaport"^^ . . "Laurence"^^ . "Faivre"^^ . "Laurence Faivre"^^ . . "Marion"^^ . "Piedmonte"^^ . "Marion Piedmonte"^^ . . "Bernardo"^^ . "Bonanni"^^ . "Bernardo Bonanni"^^ . . "Beth Y."^^ . "Karlan"^^ . "Beth Y. Karlan"^^ . . "Michel"^^ . "Longy"^^ . "Michel Longy"^^ . . "Susan J."^^ . "Ramus"^^ . "Susan J. Ramus"^^ . . "Claire"^^ . "Foo"^^ . "Claire Foo"^^ . . "Steven"^^ . "Hart"^^ . "Steven Hart"^^ . . "Evgeny N."^^ . "Imyanitov"^^ . "Evgeny N. Imyanitov"^^ . . "Julie"^^ . "Cunningham"^^ . "Julie Cunningham"^^ . . "Steve"^^ . "Ellis"^^ . "Steve Ellis"^^ . . "Tom"^^ . "Van Maerken"^^ . "Tom Van Maerken"^^ . . "Kerstin"^^ . "Rhiem"^^ . "Kerstin Rhiem"^^ . . "Heli"^^ . "Nevanlinna"^^ . "Heli Nevanlinna"^^ . . "Jenny"^^ . "Lester"^^ . "Jenny Lester"^^ . . "Rob B."^^ . "Luijt"^^ . "Rob B. Luijt"^^ . . "Raymonda"^^ . "Varon-Mateeva"^^ . "Raymonda Varon-Mateeva"^^ . . "Jacek"^^ . "Gronwald"^^ . "Jacek Gronwald"^^ . . "Maria A."^^ . "Caligo"^^ . "Maria A. Caligo"^^ . . "Gustavo C."^^ . "Rodriguez"^^ . "Gustavo C. Rodriguez"^^ . . "Francesca"^^ . "Damiola"^^ . "Francesca Damiola"^^ . . "Ros"^^ . "Eeles"^^ . "Ros Eeles"^^ . . "Ignacio"^^ . "Blanco"^^ . "Ignacio Blanco"^^ . . "Sylvie"^^ . "Mazoyer"^^ . "Sylvie Mazoyer"^^ . . "Dominique"^^ . "Stoppa-Lyonnet"^^ . "Dominique Stoppa-Lyonnet"^^ . . "Noralane"^^ . "Lindor"^^ . "Noralane Lindor"^^ . . "Gad"^^ . "Rennert"^^ . "Gad Rennert"^^ . . "Nadja"^^ . "Markov"^^ . "Nadja Markov"^^ . . "Etienne"^^ . "Rouleau"^^ . "Etienne Rouleau"^^ . . "Kai-ren"^^ . "Ong"^^ . "Kai-ren Ong"^^ . . "Robert L."^^ . "Nussbaum"^^ . "Robert L. Nussbaum"^^ . . "Hanne E"^^ . "Heijboer"^^ . "Hanne E Heijboer"^^ . . "Anneliese"^^ . "Fink-Retter"^^ . "Anneliese Fink-Retter"^^ . . "Mark"^^ . "Robson"^^ . "Mark Robson"^^ . . "Paolo"^^ . "Radice"^^ . "Paolo Radice"^^ . . "Giulietta"^^ . "Scuvera"^^ . "Giulietta Scuvera"^^ . . "Kathleen"^^ . "Claes"^^ . "Kathleen Claes"^^ . . "Sue"^^ . "Healey"^^ . "Sue Healey"^^ . . "Inge S."^^ . "Pedersen"^^ . "Inge S. Pedersen"^^ . . "Phuong L."^^ . "Mai"^^ . "Phuong L. Mai"^^ . . "D. G."^^ . "Evans"^^ . "D. G. Evans"^^ . . "Paul"^^ . "James"^^ . "Paul James"^^ . . "Ramunas"^^ . "Janavicius"^^ . "Ramunas Janavicius"^^ . . "Anna"^^ . "Jakubowska"^^ . "Anna Jakubowska"^^ . . "Cora M."^^ . "Aalfs"^^ . "Cora M. Aalfs"^^ . . "Laima"^^ . "Tihomirova"^^ . "Laima Tihomirova"^^ . . "Amanda B."^^ . "Spurdle"^^ . "Amanda B. Spurdle"^^ . . . . . . "Associations of common breast cancer susceptibility alleles with risk of breast cancer subtypes in BRCA1 and BRCA2 mutation carriers (PDF)"^^ . . . "13058_2014_Article_492.pdf"^^ . . . "Associations of common breast cancer susceptibility alleles with risk of breast cancer subtypes in BRCA1 and BRCA2 mutation carriers (Other)"^^ . . . . . . "lightbox.jpg"^^ . . . "Associations of common breast cancer susceptibility alleles with risk of breast cancer subtypes in BRCA1 and BRCA2 mutation carriers (Other)"^^ . . . . . . "preview.jpg"^^ . . . "Associations of common breast cancer susceptibility alleles with risk of breast cancer subtypes in BRCA1 and BRCA2 mutation carriers (Other)"^^ . . . . . . "medium.jpg"^^ . . . "Associations of common breast cancer susceptibility alleles with risk of breast cancer subtypes in BRCA1 and BRCA2 mutation carriers (Other)"^^ . . . . . . "small.jpg"^^ . . . "Associations of common breast cancer susceptibility alleles with risk of breast cancer subtypes in BRCA1 and BRCA2 mutation carriers (Other)"^^ . . . . . . "indexcodes.txt"^^ . . "HTML Summary of #19469 \n\nAssociations of common breast cancer susceptibility alleles with risk of breast cancer subtypes in BRCA1 and BRCA2 mutation carriers\n\n" . "text/html" . . . "610 Medizin"@de . "610 Medical sciences Medicine"@en . .