TY  - JOUR
EP  - 27
PB  - BioMed Central
UR  - https://archiv.ub.uni-heidelberg.de/volltextserver/19469/
A1  - Kuchenbäcker, Karoline B.
A1  - Neuhausen, Susan L.
A1  - Robson, Mark
A1  - Barrowdale, Daniel
A1  - McGuffog, Lesley
A1  - Mulligan, Anna M.
A1  - Andrulis, Irene L.
A1  - Spurdle, Amanda B.
A1  - Schmidt, Marjanka K.
A1  - Schmutzler, Rita K.
A1  - Engel, Christoph
A1  - Wappenschmidt, Barbara
A1  - Nevanlinna, Heli
A1  - Thomassen, Mads
A1  - Southey, Melissa
A1  - Radice, Paolo
A1  - Ramus, Susan J.
A1  - Domchek, Susan M.
A1  - Nathanson, Katherine L.
A1  - Lee, Andrew
A1  - Healey, Sue
A1  - Nussbaum, Robert L.
A1  - Rebbeck, Timothy R.
A1  - Arun, Banu K.
A1  - James, Paul
A1  - Karlan, Beth Y.
A1  - Lester, Jenny
A1  - Cass, Ilana
A1  - Terry, Mary B.
A1  - Daly, Mary B.
A1  - Goldgar, David E.
A1  - Buys, Saundra S.
A1  - Janavicius, Ramunas
A1  - Tihomirova, Laima
A1  - Tung, Nadine
A1  - Dorfling, Cecilia M.
A1  - Rensburg, Elizabeth J.
A1  - Steele, Linda
A1  - Hansen, Thomas
A1  - Ejlertsen, Bent
A1  - Gerdes, Anne-Marie
A1  - Nielsen, Finn C.
A1  - Dennis, Joe
A1  - Cunningham, Julie
A1  - Hart, Steven
A1  - Slager, Susan
A1  - Osorio, Ana
A1  - Benitez, Javier
A1  - Duran, Mercedes
A1  - Weitzel, Jeffrey N.
A1  - Tafur, Isaac
A1  - Hander, Mary
A1  - Peterlongo, Paolo
A1  - Manoukian, Siranoush
A1  - Peissel, Bernard
A1  - Roversi, Gaia
A1  - Scuvera, Giulietta
A1  - Bonanni, Bernardo
A1  - Mariani, Paolo
A1  - Volorio, Sara
A1  - Dolcetti, Riccardo
A1  - Varesco, Liliana
A1  - Papi, Laura
A1  - Tibiletti, Maria G.
A1  - Giannini, Giuseppe
A1  - Fostira, Florentia
A1  - Konstantopoulou, Irene
A1  - Garber, Judy
A1  - Hamann, Ute
A1  - Donaldson, Alan
A1  - Brewer, Carole
A1  - Foo, Claire
A1  - Evans, D. G.
A1  - Frost, Debra
A1  - Eccles, Diana
A1  - Douglas, Fiona
A1  - Brady, Angela
A1  - Cook, Jackie
A1  - Tischkowitz, Marc
A1  - Adlard, Julian
A1  - Barwell, Julian
A1  - Ong, Kai-ren
A1  - Walker, Lisa
A1  - Izatt, Louise
A1  - Side, Lucy E.
A1  - Kennedy, M. J.
A1  - Rogers, Mark T.
A1  - Porteous, Mary E.
A1  - Morrison, Patrick J.
A1  - Platte, Radka
A1  - Eeles, Ros
A1  - Davidson, Rosemarie
A1  - Hodgson, Shirley
A1  - Ellis, Steve
A1  - Godwin, Andrew K.
A1  - Rhiem, Kerstin
A1  - Meindl, Alfons
A1  - Ditsch, Nina
A1  - Arnold, Norbert
A1  - Plendl, Hansjoerg
A1  - Niederacher, Dieter
A1  - Sutter, Christian
A1  - Steinemann, Doris
A1  - Markov, Nadja
A1  - Kast, Karin
A1  - Varon-Mateeva, Raymonda
A1  - Gohrke, Shan
A1  - Gehrig, Andrea
A1  - Markiefka, Birgid
A1  - Buecher, Bruno
A1  - Lefol, Cédrick
A1  - Stoppa-Lyonnet, Dominique
A1  - Rouleau, Etienne
A1  - Prieur, Fabienne
A1  - Damiola, Francesca
A1  - Barjhoux, Laure
A1  - Faivre, Laurence
A1  - Longy, Michel
A1  - Sevenet, Nicolas
A1  - Sinilnikova, Olga M.
A1  - Mazoyer, Sylvie
A1  - Bonadona, Valérie
A1  - Caux-Moncoutier, Virginie
A1  - Isaacs, Claudine
A1  - Van Maerken, Tom
A1  - Claes, Kathleen
A1  - Piedmonte, Marion
A1  - Andrews, Lesley
A1  - Hays, John
A1  - Rodriguez, Gustavo C.
A1  - Caldes, Trinidad
A1  - de la Hoya, Miguel
A1  - Khan, Sofia
A1  - Hogervorst, Frans B.
A1  - Aalfs, Cora M.
A1  - de Lange, JL
A1  - Heijboer, Hanne E
A1  - van der Hout, Annemarie H.
A1  - Wijnen, Juul T.
A1  - van Roozendaal, KEP
A1  - Mensenkamp, Arjen R.
A1  - Ouweland, Ans M.
A1  - Deurzen, Carolien H.
A1  - Luijt, Rob B.
A1  - Olah, Edith
A1  - Diez, Orland
A1  - Lazaro, Conxi
A1  - Blanco, Ignacio
A1  - Teulé, Alex
A1  - Menendez, Mireia
A1  - Jakubowska, Anna
A1  - Lubinski, Jan
A1  - Cybulski, Cezary
A1  - Gronwald, Jacek
A1  - Jaworska-Bieniek, Katarzyna
A1  - Durda, Katarzyna
A1  - Arason, Adalgeir
A1  - Maugard, Christine
A1  - Soucy, Penny
A1  - Montagna, Marco
A1  - Agata, Simona
A1  - Teixeira, Manuel R.
A1  - Olswold, Curtis
A1  - Lindor, Noralane
A1  - Pankratz, Vernon S.
A1  - Hallberg, Emily
A1  - Wang, Xianshu
A1  - Szabo, Csilla I.
A1  - Vijai, Joseph
A1  - Jacobs, Lauren
A1  - Corines, Marina
A1  - Lincoln, Anne
A1  - Berger, Andreas
A1  - Fink-Retter, Anneliese
A1  - Singer, Christian F.
A1  - Rappaport, Christine
A1  - Gschwantler Kaulich, Daphne
A1  - Pfeiler, Georg
A1  - Tea, Muy-Kheng
A1  - Phelan, Catherine M.
A1  - Mai, Phuong L.
A1  - Greene, Mark H.
A1  - Rennert, Gad
A1  - Imyanitov, Evgeny N.
A1  - Glendon, Gord
A1  - Toland, Amanda E.
A1  - Bojesen, Anders
A1  - Pedersen, Inge S.
A1  - Jensen, Uffe B.
A1  - Caligo, Maria A.
A1  - Friedman, Eitan
A1  - Berger, Raanan
A1  - Laitman, Yael
A1  - Rantala, Johanna
A1  - Arver, Brita
A1  - Loman, Niklas
A1  - Borg, Ake
A1  - Ehrencrona, Hans
A1  - Olopade, Olufunmilayo I.
A1  - Simard, Jacques
A1  - Easton, Douglas F.
A1  - Chenevix-Trench, Georgia
A1  - Offit, Kenneth
A1  - Couch, Fergus J.
A1  - Antoniou, Antonis C.
IS  - 3416
CY  - London
VL  - 16
JF  - Breast cancer research
ID  - heidok19469
TI  - Associations of common breast cancer susceptibility alleles with risk of breast cancer subtypes in BRCA1 and BRCA2 mutation carriers
Y1  - 2014///
AV  - public
SN  - 1465-542X
N2  - Introduction: More than 70 common alleles are known to be involved in breast cancer (BC) susceptibility, and several exhibit significant heterogeneity in their associations with different BC subtypes. Although there are differences in the association patterns between BRCA1 and BRCA2 mutation carriers and the general population for several loci, no study has comprehensively evaluated the associations of all known BC susceptibility alleles with risk of BC subtypes in BRCA1 and BRCA2 carriers.   Methods: We used data from 15,252 BRCA1 and 8,211 BRCA2 carriers to analyze the associations between approximately 200,000 genetic variants on the iCOGS array and risk of BC subtypes defined by estrogen receptor (ER), progesterone receptor (PR), human epidermal growth factor receptor 2 (HER2) and triple-negative- (TN) status; morphologic subtypes; histological grade; and nodal involvement.   Results: The estimated BC hazard ratios (HRs) for the 74 known BC alleles in BRCA1 carriers exhibited moderate correlations with the corresponding odds ratios from the general population. However, their associations with ER-positive BC in BRCA1 carriers were more consistent with the ER-positive associations in the general population (intraclass correlation (ICC)?=?0.61, 95% confidence interval (CI): 0.45 to 0.74), and the same was true when considering ER-negative associations in both groups (ICC?=?0.59, 95% CI: 0.42 to 0.72). Similarly, there was strong correlation between the ER-positive associations for BRCA1 and BRCA2 carriers (ICC?=?0.67, 95% CI: 0.52 to 0.78), whereas ER-positive associations in any one of the groups were generally inconsistent with ER-negative associations in any of the others. After stratifying by ER status in mutation carriers, additional significant associations were observed. Several previously unreported variants exhibited associations at P <10?6 in the analyses by PR status, HER2 status, TN phenotype, morphologic subtypes, histological grade and nodal involvement.   Conclusions: Differences in associations of common BC susceptibility alleles between BRCA1 and BRCA2 carriers and the general population are explained to a large extent by differences in the prevalence of ER-positive and ER-negative tumors. Estimates of the risks associated with these variants based on population-based studies are likely to be applicable to mutation carriers after taking ER status into account, which has implications for risk prediction.  
SP  - 1
ER  -