title: Genetic variation at CYP3A is associated with age at menarche and breast cancer risk: a case-control study
creator: Johnson, Nichola
creator: Dudbridge, Frank
creator: Orr, Nick
creator: Gibson, Lorna
creator: Jones, Michael E.
creator: Schoemaker, Minouk J.
creator: Folkerd, Elizabeth J.
creator: Haynes, Ben P.
creator: Hopper, John L.
creator: Southey, Melissa C.
creator: Dite, Gillian S.
creator: Apicella, Carmel
creator: Schmidt, Marjanka K.
creator: Broeks, Annegien
creator: Van’t Veer, Laura J.
creator: Atsma, Femke
creator: Muir, Kenneth
creator: Lophatananon, Artitaya
creator: Fasching, Peter A.
creator: Beckmann, Matthias W.
creator: Ekici, Arif B.
creator: Renner, Stefan P.
creator: Sawyer, Elinor
creator: Tomlinson, Ian
creator: Kerin, Michael
creator: Miller, Nicola
creator: Burwinkel, Barbara
creator: Marme, Frederik
creator: Schneeweiß, Andreas
creator: Sohn, Christof
creator: Guénel, Pascal
creator: Truong, Therese
creator: Cordina, Emilie
creator: Menegaux, Florence
creator: Bojesen, Stig E.
creator: Nordestgaard, Børge G.
creator: Flyger, Henrik
creator: Milne, Roger
creator: Zamora, M. Pilar
creator: Perez, Jose Ignacio Arias
creator: Benitez, Javier
creator: Bernstein, Leslie
creator: Anton-Culver, Hoda
creator: Ziogas, Argyrios
creator: Clarke Dur, Christina
creator: Brenner, Hermann
creator: Müller, Heiko
creator: Arndt, Volker
creator: Dieffenbach, Aida Karina
creator: Meindl, Alfons
creator: Heil, Jörg
creator: Bartram, Claus R.
creator: Schmutzler, Rita K.
creator: Brauch, Hiltrud
creator: Justenhoven, Christina
creator: Ko, Yon-Dschun
creator: Nevanlinna, Heli
creator: Muranen, Taru A.
creator: Aittomäki, Kristiina
creator: Blomqvist, Carl
creator: Matsuo, Keitaro
creator: Dörk, Thilo
creator: Bogdanova, Natalia V.
creator: Antonenkova, Natalia N.
creator: Lindblom, Annika
creator: Mannermaa, Arto
creator: Kataja, Vesa
creator: Kosma, Veli-Matti
creator: Hartikainen, Jaana M
creator: Chenevix-Trench, Georgia
creator: Beesley, Jonathan
creator: Wu, Anna H.
creator: Van den Berg, David
creator: Tseng, Chiu-Chen
creator: Lambrechts, Diether
creator: Smeets, Dominiek
creator: Neven, Patrick
creator: Wildiers, Hans
creator: Chang-Claude, Jenny
creator: Rudolph, Anja
creator: Nickels, Stefan
creator: Flesch-Janys, Dieter
creator: Radice, Paolo
creator: Peterlongo, Paolo
creator: Bonanni, Bernardo
creator: Pensotti, Valeria
creator: Couch, Fergus J.
creator: Olson, Janet E.
creator: Wang, Xianshu
creator: Fredericksen, Zachary
creator: Pankratz, Vernon S.
creator: Giles, Graham G.
creator: Severi, Gianluca
creator: Baglietto, Laura
creator: Haiman, Chris
creator: Simard, Jacques
creator: Goldberg, Mark S
creator: Labrèche, France
creator: Dumont, Martine
creator: Soucy, Penny
creator: Teo, Soo
creator: Yip, Cheng Har
creator: Phuah, Sze Yee
creator: Cornes, Belinda K.
creator: Kristensen, Vessela N.
creator: Grenaker Alnæs, Grethe
creator: Børresen-Dale, Anne-Lise
creator: Zheng, Wei
creator: Winqvist, Robert
creator: Pylkäs, Katri
creator: Jukkola-Vuorinen, Arja
creator: Grip, Mervi
creator: Andrulis, Irene L.
creator: Knight, Julia A.
creator: Glendon, Gord
creator: Mulligan, Anna Marie
creator: Devillee, Peter
creator: Figueroa, Jonine
creator: Chanock, Stephen J.
creator: Lissowska, Jolanta
creator: Sherman, Mark E
creator: Hall, Per
creator: Schoof, Nils
creator: Hooning, Maartje
creator: Hollestelle, Antoinette
creator: Oldenburg, Rogier A.
creator: Tilanus-Linthorst, Madeleine
creator: Liu, Jianjun
creator: Cox, Angie
creator: Brock, Ian W.
creator: Reed, Malcolm WR
creator: Cross, Simon S.
creator: Blot, William
creator: Signorello, Lisa B.
creator: Pharoah, Paul DP
creator: Dunning, Alison M.
creator: Shah, Mitul
creator: Kang, Daehee
creator: Noh, Dong-Young
creator: Park, Sue K.
creator: Choi, Ji-Yeob
creator: Hartman, Mikael
creator: Miao, Hui
creator: Lim, Wei Yen
creator: Tang, Anthony
creator: Hamann, Ute
creator: Försti, Asta
creator: Rüdiger, Thomas
creator: Ulmer, Hans U.
creator: Jakubowska, Anna
creator: Lubinski, Jan
creator: Jaworska-Bieniek, Katarzyna
creator: Durda, Katarzyna
creator: Sangrajrang, Suleeporn
creator: Gaborieau, Valerie
creator: Brennan, Paul
creator: McKay, James
creator: Slager, Susan
creator: Toland, Amanda E
creator: Vachon, Celine
creator: Yannoukakos, Drakoulis
creator: Shen, Chen-Yang
creator: Yu, Jyh-Cherng
creator: Huang, Chiun-Sheng
creator: Hou, Ming-Feng
creator: González-Neira, Anna
creator: Tessier, Daniel C.
creator: Vincent, Daniel
creator: Bacot, Francois
creator: Luccarini, Craig
creator: Dennis, Joe
creator: Michailidou, Kyriaki
creator: Bolla, Manjeet K.
creator: Wang, Jean
creator: Easton, Douglas F.
creator: García-Closas, Montserrat
creator: Dowsett, Mitch
creator: Ashworth, Alan
creator: Swerdlow, Anthony J.
creator: Peto, Julian
creator: dos Santos Silva, Isabel
creator: Fletcher, Olivia
subject: ddc-610
subject: 610 Medical sciences Medicine
description: Introduction: We have previously shown that a tag single nucleotide polymorphism (rs10235235), which maps to the CYP3A locus (7q22.1), was associated with a reduction in premenopausal urinary estrone glucuronide levels and a modest reduction in risk of breast cancer in women age ≤50 years.   Methods: We further investigated the association of rs10235235 with breast cancer risk in a large case control study of 47,346 cases and 47,570 controls from 52 studies participating in the Breast Cancer Association Consortium. Genotyping of rs10235235 was conducted using a custom Illumina Infinium array. Stratified analyses were conducted to determine whether this association was modified by age at diagnosis, ethnicity, age at menarche or tumor characteristics.   Results: We confirmed the association of rs10235235 with breast cancer risk for women of European ancestry but found no evidence that this association differed with age at diagnosis. Heterozygote and homozygote odds ratios (ORs) were OR = 0.98 (95% CI 0.94, 1.01; P = 0.2) and OR = 0.80 (95% CI 0.69, 0.93; P = 0.004), respectively (P trend = 0.02). There was no evidence of effect modification by tumor characteristics. rs10235235 was, however, associated with age at menarche in controls (P trend = 0.005) but not cases (P trend = 0.97). Consequently the association between rs10235235 and breast cancer risk differed according to age at menarche (P het = 0.02); the rare allele of rs10235235 was associated with a reduction in breast cancer risk for women who had their menarche age ≥15 years (ORhet = 0.84, 95% CI 0.75, 0.94; ORhom = 0.81, 95% CI 0.51, 1.30; P trend = 0.002) but not for those who had their menarche age ≤11 years (ORhet = 1.06, 95% CI 0.95, 1.19, ORhom = 1.07, 95% CI 0.67, 1.72; P trend = 0.29).   Conclusions: To our knowledge rs10235235 is the first single nucleotide polymorphism to be associated with both breast cancer risk and age at menarche consistent with the well-documented association between later age at menarche and a reduction in breast cancer risk. These associations are likely mediated via an effect on circulating hormone levels.  
publisher: BioMed Central
date: 2014
type: Article
type: info:eu-repo/semantics/article
type: NonPeerReviewed
format: application/pdf
identifier: https://archiv.ub.uni-heidelberg.de/volltextserver/19475/1/13058_2013_Article_3558.pdf
identifier: DOI:
identifier: urn:nbn:de:bsz:16-heidok-194755
identifier:   Johnson, Nichola ; Dudbridge, Frank ; Orr, Nick ; Gibson, Lorna ; Jones, Michael E. ; Schoemaker, Minouk J. ; Folkerd, Elizabeth J. ; Haynes, Ben P. ; Hopper, John L. ; Southey, Melissa C. ; Dite, Gillian S. ; Apicella, Carmel ; Schmidt, Marjanka K. ; Broeks, Annegien ; Van’t Veer, Laura J. ; Atsma, Femke ; Muir, Kenneth ; Lophatananon, Artitaya ; Fasching, Peter A. ; Beckmann, Matthias W. ; Ekici, Arif B. ; Renner, Stefan P. ; Sawyer, Elinor ; Tomlinson, Ian ; Kerin, Michael ; Miller, Nicola ; Burwinkel, Barbara ; Marme, Frederik ; Schneeweiß, Andreas ; Sohn, Christof ; Guénel, Pascal ; Truong, Therese ; Cordina, Emilie ; Menegaux, Florence ; Bojesen, Stig E. ; Nordestgaard, Børge G. ; Flyger, Henrik ; Milne, Roger ; Zamora, M. Pilar ; Perez, Jose Ignacio Arias ; Benitez, Javier ; Bernstein, Leslie ; Anton-Culver, Hoda ; Ziogas, Argyrios ; Clarke Dur, Christina ; Brenner, Hermann ; Müller, Heiko ; Arndt, Volker ; Dieffenbach, Aida Karina ; Meindl, Alfons ; Heil, Jörg ; Bartram, Claus R. ; Schmutzler, Rita K. ; Brauch, Hiltrud ; Justenhoven, Christina ; Ko, Yon-Dschun ; Nevanlinna, Heli ; Muranen, Taru A. ; Aittomäki, Kristiina ; Blomqvist, Carl ; Matsuo, Keitaro ; Dörk, Thilo ; Bogdanova, Natalia V. ; Antonenkova, Natalia N. ; Lindblom, Annika ; Mannermaa, Arto ; Kataja, Vesa ; Kosma, Veli-Matti ; Hartikainen, Jaana M ; Chenevix-Trench, Georgia ; Beesley, Jonathan ; Wu, Anna H. ; Van den Berg, David ; Tseng, Chiu-Chen ; Lambrechts, Diether ; Smeets, Dominiek ; Neven, Patrick ; Wildiers, Hans ; Chang-Claude, Jenny ; Rudolph, Anja ; Nickels, Stefan ; Flesch-Janys, Dieter ; Radice, Paolo ; Peterlongo, Paolo ; Bonanni, Bernardo ; Pensotti, Valeria ; Couch, Fergus J. ; Olson, Janet E. ; Wang, Xianshu ; Fredericksen, Zachary ; Pankratz, Vernon S. ; Giles, Graham G. ; Severi, Gianluca ; Baglietto, Laura ; Haiman, Chris ; Simard, Jacques ; Goldberg, Mark S ; Labrèche, France ; Dumont, Martine ; Soucy, Penny ; Teo, Soo ; Yip, Cheng Har ; Phuah, Sze Yee ; Cornes, Belinda K. ; Kristensen, Vessela N. ; Grenaker Alnæs, Grethe ; Børresen-Dale, Anne-Lise ; Zheng, Wei ; Winqvist, Robert ; Pylkäs, Katri ; Jukkola-Vuorinen, Arja ; Grip, Mervi ; Andrulis, Irene L. ; Knight, Julia A. ; Glendon, Gord ; Mulligan, Anna Marie ; Devillee, Peter ; Figueroa, Jonine ; Chanock, Stephen J. ; Lissowska, Jolanta ; Sherman, Mark E ; Hall, Per ; Schoof, Nils ; Hooning, Maartje ; Hollestelle, Antoinette ; Oldenburg, Rogier A. ; Tilanus-Linthorst, Madeleine ; Liu, Jianjun ; Cox, Angie ; Brock, Ian W. ; Reed, Malcolm WR ; Cross, Simon S. ; Blot, William ; Signorello, Lisa B. ; Pharoah, Paul DP ; Dunning, Alison M. ; Shah, Mitul ; Kang, Daehee ; Noh, Dong-Young ; Park, Sue K. ; Choi, Ji-Yeob ; Hartman, Mikael ; Miao, Hui ; Lim, Wei Yen ; Tang, Anthony ; Hamann, Ute ; Försti, Asta ; Rüdiger, Thomas ; Ulmer, Hans U. ; Jakubowska, Anna ; Lubinski, Jan ; Jaworska-Bieniek, Katarzyna ; Durda, Katarzyna ; Sangrajrang, Suleeporn ; Gaborieau, Valerie ; Brennan, Paul ; McKay, James ; Slager, Susan ; Toland, Amanda E ; Vachon, Celine ; Yannoukakos, Drakoulis ; Shen, Chen-Yang ; Yu, Jyh-Cherng ; Huang, Chiun-Sheng ; Hou, Ming-Feng ; González-Neira, Anna ; Tessier, Daniel C. ; Vincent, Daniel ; Bacot, Francois ; Luccarini, Craig ; Dennis, Joe ; Michailidou, Kyriaki ; Bolla, Manjeet K. ; Wang, Jean ; Easton, Douglas F. ; García-Closas, Montserrat ; Dowsett, Mitch ; Ashworth, Alan ; Swerdlow, Anthony J. ; Peto, Julian ; dos Santos Silva, Isabel ; Fletcher, Olivia  (2014) Genetic variation at CYP3A is associated with age at menarche and breast cancer risk: a case-control study.  Breast cancer research, 16 (R51).  pp. 1-13.  ISSN 1465-542X     
relation: https://archiv.ub.uni-heidelberg.de/volltextserver/19475/
rights: info:eu-repo/semantics/openAccess
rights: Please see front page of the work (Sorry, Dublin Core plugin does not recognise license id)
language: eng