<> "The repository administrator has not yet configured an RDF license."^^ . <> . . . "Genetic variation at CYP3A is associated with age at menarche and breast cancer risk: a case-control study"^^ . "Introduction: We have previously shown that a tag single nucleotide polymorphism (rs10235235), which maps to the CYP3A locus (7q22.1), was associated with a reduction in premenopausal urinary estrone glucuronide levels and a modest reduction in risk of breast cancer in women age ≤50 years. Methods: We further investigated the association of rs10235235 with breast cancer risk in a large case control study of 47,346 cases and 47,570 controls from 52 studies participating in the Breast Cancer Association Consortium. Genotyping of rs10235235 was conducted using a custom Illumina Infinium array. Stratified analyses were conducted to determine whether this association was modified by age at diagnosis, ethnicity, age at menarche or tumor characteristics. Results: We confirmed the association of rs10235235 with breast cancer risk for women of European ancestry but found no evidence that this association differed with age at diagnosis. Heterozygote and homozygote odds ratios (ORs) were OR = 0.98 (95% CI 0.94, 1.01; P = 0.2) and OR = 0.80 (95% CI 0.69, 0.93; P = 0.004), respectively (P trend = 0.02). There was no evidence of effect modification by tumor characteristics. rs10235235 was, however, associated with age at menarche in controls (P trend = 0.005) but not cases (P trend = 0.97). Consequently the association between rs10235235 and breast cancer risk differed according to age at menarche (P het = 0.02); the rare allele of rs10235235 was associated with a reduction in breast cancer risk for women who had their menarche age ≥15 years (ORhet = 0.84, 95% CI 0.75, 0.94; ORhom = 0.81, 95% CI 0.51, 1.30; P trend = 0.002) but not for those who had their menarche age ≤11 years (ORhet = 1.06, 95% CI 0.95, 1.19, ORhom = 1.07, 95% CI 0.67, 1.72; P trend = 0.29). Conclusions: To our knowledge rs10235235 is the first single nucleotide polymorphism to be associated with both breast cancer risk and age at menarche consistent with the well-documented association between later age at menarche and a reduction in breast cancer risk. These associations are likely mediated via an effect on circulating hormone levels. "^^ . "2014" . . "16" . "R51" . . "BioMed Central"^^ . . . "Breast cancer research"^^ . . . "1465542X" . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . "Ute"^^ . "Hamann"^^ . "Ute Hamann"^^ . . "Asta"^^ . "Försti"^^ . "Asta Försti"^^ . . "Douglas F."^^ . "Easton"^^ . "Douglas F. Easton"^^ . . "Ming-Feng"^^ . "Hou"^^ . "Ming-Feng Hou"^^ . . "Anthony"^^ . "Tang"^^ . "Anthony Tang"^^ . . "Dong-Young"^^ . "Noh"^^ . "Dong-Young Noh"^^ . . "Jan"^^ . "Lubinski"^^ . "Jan Lubinski"^^ . . "Maartje"^^ . "Hooning"^^ . "Maartje Hooning"^^ . . "Gianluca"^^ . "Severi"^^ . "Gianluca Severi"^^ . . "Francois"^^ . "Bacot"^^ . "Francois Bacot"^^ . . "Minouk J."^^ . "Schoemaker"^^ . "Minouk J. Schoemaker"^^ . . "Carmel"^^ . "Apicella"^^ . "Carmel Apicella"^^ . . "Alan"^^ . "Ashworth"^^ . "Alan Ashworth"^^ . . "Arja"^^ . "Jukkola-Vuorinen"^^ . "Arja Jukkola-Vuorinen"^^ . . "Hermann"^^ . "Brenner"^^ . "Hermann Brenner"^^ . . "Suleeporn"^^ . "Sangrajrang"^^ . "Suleeporn Sangrajrang"^^ . . "Pascal"^^ . "Guénel"^^ . "Pascal Guénel"^^ . . "Grethe"^^ . "Grenaker Alnæs"^^ . "Grethe Grenaker Alnæs"^^ . . "Janet E."^^ . "Olson"^^ . "Janet E. Olson"^^ . . "Soo"^^ . "Teo"^^ . "Soo Teo"^^ . . "Vessela N."^^ . "Kristensen"^^ . "Vessela N. Kristensen"^^ . . "Lorna"^^ . "Gibson"^^ . "Lorna Gibson"^^ . . "Chen-Yang"^^ . "Shen"^^ . "Chen-Yang Shen"^^ . . "Arto"^^ . "Mannermaa"^^ . "Arto Mannermaa"^^ . . "Hoda"^^ . "Anton-Culver"^^ . "Hoda Anton-Culver"^^ . . "David"^^ . "Van den Berg"^^ . "David Van den Berg"^^ . . "Jonine"^^ . "Figueroa"^^ . "Jonine Figueroa"^^ . . "Stig E."^^ . "Bojesen"^^ . "Stig E. Bojesen"^^ . . "Martine"^^ . "Dumont"^^ . "Martine Dumont"^^ . . "Per"^^ . "Hall"^^ . "Per Hall"^^ . . "Jonathan"^^ . "Beesley"^^ . "Jonathan Beesley"^^ . . "Carl"^^ . "Blomqvist"^^ . "Carl Blomqvist"^^ . . "Annika"^^ . "Lindblom"^^ . "Annika Lindblom"^^ . . "Wei"^^ . "Zheng"^^ . "Wei Zheng"^^ . . "Alison M."^^ . "Dunning"^^ . "Alison M. Dunning"^^ . . "Mikael"^^ . "Hartman"^^ . "Mikael Hartman"^^ . . "Vesa"^^ . "Kataja"^^ . "Vesa Kataja"^^ . . "Lisa B."^^ . "Signorello"^^ . "Lisa B. Signorello"^^ . . "Cheng Har"^^ . "Yip"^^ . "Cheng Har Yip"^^ . . "Montserrat"^^ . "García-Closas"^^ . "Montserrat García-Closas"^^ . . "Frederik"^^ . "Marme"^^ . "Frederik Marme"^^ . . "Julian"^^ . "Peto"^^ . "Julian Peto"^^ . . "Katarzyna"^^ . "Jaworska-Bieniek"^^ . "Katarzyna Jaworska-Bieniek"^^ . . "Peter A."^^ . "Fasching"^^ . "Peter A. Fasching"^^ . . "Anna"^^ . "González-Neira"^^ . "Anna González-Neira"^^ . . "Barbara"^^ . "Burwinkel"^^ . "Barbara Burwinkel"^^ . . "Anne-Lise"^^ . "Børresen-Dale"^^ . "Anne-Lise Børresen-Dale"^^ . . "Graham G."^^ . "Giles"^^ . "Graham G. Giles"^^ . . "Veli-Matti"^^ . "Kosma"^^ . "Veli-Matti Kosma"^^ . . "Mark S"^^ . "Goldberg"^^ . "Mark S Goldberg"^^ . . "Ian"^^ . "Tomlinson"^^ . "Ian Tomlinson"^^ . . "Javier"^^ . "Benitez"^^ . "Javier Benitez"^^ . . "Paul"^^ . "Brennan"^^ . "Paul Brennan"^^ . . "Hans U."^^ . "Ulmer"^^ . "Hans U. Ulmer"^^ . . "Paolo"^^ . "Peterlongo"^^ . "Paolo Peterlongo"^^ . . "Hiltrud"^^ . "Brauch"^^ . "Hiltrud Brauch"^^ . . "Frank"^^ . "Dudbridge"^^ . "Frank Dudbridge"^^ . . "Wei Yen"^^ . "Lim"^^ . "Wei Yen Lim"^^ . . "Hui"^^ . "Miao"^^ . "Hui Miao"^^ . . "Irene L."^^ . "Andrulis"^^ . "Irene L. Andrulis"^^ . . "M. Pilar"^^ . "Zamora"^^ . "M. Pilar Zamora"^^ . . "Ian W."^^ . "Brock"^^ . "Ian W. Brock"^^ . . "Celine"^^ . "Vachon"^^ . "Celine Vachon"^^ . . "Stefan"^^ . "Nickels"^^ . "Stefan Nickels"^^ . . "Nicola"^^ . "Miller"^^ . "Nicola Miller"^^ . . "Christina"^^ . "Justenhoven"^^ . "Christina Justenhoven"^^ . . "Patrick"^^ . "Neven"^^ . "Patrick Neven"^^ . . "Therese"^^ . "Truong"^^ . "Therese Truong"^^ . . "Mark E"^^ . "Sherman"^^ . "Mark E Sherman"^^ . . "Jianjun"^^ . "Liu"^^ . "Jianjun Liu"^^ . . "Kenneth"^^ . "Muir"^^ . "Kenneth Muir"^^ . . "Diether"^^ . "Lambrechts"^^ . "Diether Lambrechts"^^ . . "Joe"^^ . "Dennis"^^ . "Joe Dennis"^^ . . "Georgia"^^ . "Chenevix-Trench"^^ . "Georgia Chenevix-Trench"^^ . . "Hans"^^ . "Wildiers"^^ . "Hans Wildiers"^^ . . "Thilo"^^ . "Dörk"^^ . "Thilo Dörk"^^ . . "Anthony J."^^ . "Swerdlow"^^ . "Anthony J. Swerdlow"^^ . . "Malcolm WR"^^ . "Reed"^^ . "Malcolm WR Reed"^^ . . "Henrik"^^ . "Flyger"^^ . "Henrik Flyger"^^ . . "Ji-Yeob"^^ . "Choi"^^ . "Ji-Yeob Choi"^^ . . "Craig"^^ . "Luccarini"^^ . "Craig Luccarini"^^ . . "Jörg"^^ . "Heil"^^ . "Jörg Heil"^^ . . "Sze Yee"^^ . "Phuah"^^ . "Sze Yee Phuah"^^ . . "Fergus J."^^ . "Couch"^^ . "Fergus J. Couch"^^ . . "Jyh-Cherng"^^ . "Yu"^^ . "Jyh-Cherng Yu"^^ . . "Argyrios"^^ . "Ziogas"^^ . "Argyrios Ziogas"^^ . . "Leslie"^^ . "Bernstein"^^ . "Leslie Bernstein"^^ . . "Arif B."^^ . "Ekici"^^ . "Arif B. Ekici"^^ . . "Børge G."^^ . "Nordestgaard"^^ . "Børge G. Nordestgaard"^^ . . "Peter"^^ . "Devillee"^^ . "Peter Devillee"^^ . . "Drakoulis"^^ . "Yannoukakos"^^ . "Drakoulis Yannoukakos"^^ . . "Sue K."^^ . "Park"^^ . "Sue K. Park"^^ . . "Katri"^^ . "Pylkäs"^^ . "Katri Pylkäs"^^ . . "Laura J."^^ . "Van’t Veer"^^ . "Laura J. Van’t Veer"^^ . . "Kristiina"^^ . "Aittomäki"^^ . "Kristiina Aittomäki"^^ . . "Nils"^^ . "Schoof"^^ . "Nils Schoof"^^ . . "William"^^ . "Blot"^^ . "William Blot"^^ . . "Paolo"^^ . "Radice"^^ . "Paolo Radice"^^ . . "Robert"^^ . "Winqvist"^^ . "Robert Winqvist"^^ . . "Amanda E"^^ . "Toland"^^ . "Amanda E Toland"^^ . . "Dieter"^^ . "Flesch-Janys"^^ . "Dieter Flesch-Janys"^^ . . "Daehee"^^ . "Kang"^^ . "Daehee Kang"^^ . . "Laura"^^ . "Baglietto"^^ . "Laura Baglietto"^^ . . "Dominiek"^^ . "Smeets"^^ . "Dominiek Smeets"^^ . . "Penny"^^ . "Soucy"^^ . "Penny Soucy"^^ . . "Thomas"^^ . "Rüdiger"^^ . "Thomas Rüdiger"^^ . . "Natalia V."^^ . "Bogdanova"^^ . "Natalia V. Bogdanova"^^ . . "Nichola"^^ . "Johnson"^^ . "Nichola Johnson"^^ . . "Annegien"^^ . "Broeks"^^ . "Annegien Broeks"^^ . . "Alfons"^^ . "Meindl"^^ . "Alfons Meindl"^^ . . "James"^^ . "McKay"^^ . "James McKay"^^ . . "Marjanka K."^^ . "Schmidt"^^ . "Marjanka K. Schmidt"^^ . . "Nick"^^ . "Orr"^^ . "Nick Orr"^^ . . "Femke"^^ . "Atsma"^^ . "Femke Atsma"^^ . . "Belinda K."^^ . "Cornes"^^ . "Belinda K. Cornes"^^ . . "Keitaro"^^ . "Matsuo"^^ . "Keitaro Matsuo"^^ . . "Claus R."^^ . "Bartram"^^ . "Claus R. Bartram"^^ . . "Chris"^^ . "Haiman"^^ . "Chris Haiman"^^ . . "Volker"^^ . "Arndt"^^ . "Volker Arndt"^^ . . "Ben P."^^ . "Haynes"^^ . "Ben P. Haynes"^^ . . "Matthias W."^^ . "Beckmann"^^ . "Matthias W. Beckmann"^^ . . "Mitul"^^ . "Shah"^^ . "Mitul Shah"^^ . . "Stefan P."^^ . "Renner"^^ . "Stefan P. Renner"^^ . . "Elizabeth J."^^ . "Folkerd"^^ . "Elizabeth J. Folkerd"^^ . . "Taru A."^^ . "Muranen"^^ . "Taru A. Muranen"^^ . . "Michael E."^^ . "Jones"^^ . "Michael E. Jones"^^ . . "Chiu-Chen"^^ . "Tseng"^^ . "Chiu-Chen Tseng"^^ . . "Gord"^^ . "Glendon"^^ . "Gord Glendon"^^ . . "Jenny"^^ . "Chang-Claude"^^ . "Jenny Chang-Claude"^^ . . "Susan"^^ . "Slager"^^ . "Susan Slager"^^ . . "Anja"^^ . "Rudolph"^^ . "Anja Rudolph"^^ . . "Mitch"^^ . "Dowsett"^^ . "Mitch Dowsett"^^ . . "Christof"^^ . "Sohn"^^ . "Christof Sohn"^^ . . "Daniel C."^^ . "Tessier"^^ . "Daniel C. Tessier"^^ . . "Jacques"^^ . "Simard"^^ . "Jacques Simard"^^ . . "Roger"^^ . "Milne"^^ . "Roger Milne"^^ . . "Aida Karina"^^ . "Dieffenbach"^^ . "Aida Karina Dieffenbach"^^ . . "Angie"^^ . "Cox"^^ . "Angie Cox"^^ . . "Michael"^^ . "Kerin"^^ . "Michael Kerin"^^ . . "Gillian S."^^ . "Dite"^^ . "Gillian S. Dite"^^ . . "Natalia N."^^ . "Antonenkova"^^ . "Natalia N. Antonenkova"^^ . . "Julia A."^^ . "Knight"^^ . "Julia A. Knight"^^ . . "France"^^ . "Labrèche"^^ . "France Labrèche"^^ . . "Isabel"^^ . "dos Santos Silva"^^ . "Isabel dos Santos Silva"^^ . . "Jose Ignacio Arias"^^ . "Perez"^^ . "Jose Ignacio Arias Perez"^^ . . "Jaana M"^^ . "Hartikainen"^^ . "Jaana M Hartikainen"^^ . . "Rita K."^^ . "Schmutzler"^^ . "Rita K. Schmutzler"^^ . . "Stephen J."^^ . "Chanock"^^ . "Stephen J. Chanock"^^ . . "Paul DP"^^ . "Pharoah"^^ . "Paul DP Pharoah"^^ . . "Jolanta"^^ . "Lissowska"^^ . "Jolanta Lissowska"^^ . . "Anna"^^ . "Jakubowska"^^ . "Anna Jakubowska"^^ . . "Anna H."^^ . "Wu"^^ . "Anna H. Wu"^^ . . "Kyriaki"^^ . "Michailidou"^^ . "Kyriaki Michailidou"^^ . . "Daniel"^^ . "Vincent"^^ . "Daniel Vincent"^^ . . "Zachary"^^ . "Fredericksen"^^ . "Zachary Fredericksen"^^ . . "Bernardo"^^ . "Bonanni"^^ . "Bernardo Bonanni"^^ . . "Melissa C."^^ . "Southey"^^ . "Melissa C. Southey"^^ . . "Simon S."^^ . "Cross"^^ . "Simon S. Cross"^^ . . "Katarzyna"^^ . "Durda"^^ . "Katarzyna Durda"^^ . . "Xianshu"^^ . "Wang"^^ . "Xianshu Wang"^^ . . "Olivia"^^ . "Fletcher"^^ . "Olivia Fletcher"^^ . . "Artitaya"^^ . "Lophatananon"^^ . "Artitaya Lophatananon"^^ . . "Chiun-Sheng"^^ . "Huang"^^ . "Chiun-Sheng Huang"^^ . . "Andreas"^^ . "Schneeweiß"^^ . "Andreas Schneeweiß"^^ . . "Emilie"^^ . "Cordina"^^ . "Emilie Cordina"^^ . . "Florence"^^ . "Menegaux"^^ . "Florence Menegaux"^^ . . "John L."^^ . "Hopper"^^ . "John L. Hopper"^^ . . "Rogier A."^^ . "Oldenburg"^^ . "Rogier A. Oldenburg"^^ . . "Valeria"^^ . "Pensotti"^^ . "Valeria Pensotti"^^ . . "Madeleine"^^ . "Tilanus-Linthorst"^^ . "Madeleine Tilanus-Linthorst"^^ . . "Vernon S."^^ . "Pankratz"^^ . "Vernon S. Pankratz"^^ . . "Jean"^^ . "Wang"^^ . "Jean Wang"^^ . . "Heiko"^^ . "Müller"^^ . "Heiko Müller"^^ . . "Christina"^^ . "Clarke Dur"^^ . "Christina Clarke Dur"^^ . . "Antoinette"^^ . "Hollestelle"^^ . "Antoinette Hollestelle"^^ . . "Yon-Dschun"^^ . "Ko"^^ . "Yon-Dschun Ko"^^ . . "Heli"^^ . "Nevanlinna"^^ . "Heli Nevanlinna"^^ . . "Valerie"^^ . "Gaborieau"^^ . "Valerie Gaborieau"^^ . . "Mervi"^^ . "Grip"^^ . "Mervi Grip"^^ . . "Elinor"^^ . "Sawyer"^^ . "Elinor Sawyer"^^ . . "Anna Marie"^^ . "Mulligan"^^ . "Anna Marie Mulligan"^^ . . "Manjeet K."^^ . "Bolla"^^ . "Manjeet K. Bolla"^^ . . . . . . "Genetic variation at CYP3A is associated with age at menarche and breast cancer risk: a case-control study (PDF)"^^ . . . "13058_2013_Article_3558.pdf"^^ . . . "Genetic variation at CYP3A is associated with age at menarche and breast cancer risk: a case-control study (Other)"^^ . . . . . . "indexcodes.txt"^^ . . . "Genetic variation at CYP3A is associated with age at menarche and breast cancer risk: a case-control study (Other)"^^ . . . . . . "lightbox.jpg"^^ . . . "Genetic variation at CYP3A is associated with age at menarche and breast cancer risk: a case-control study (Other)"^^ . . . . . . "preview.jpg"^^ . . . "Genetic variation at CYP3A is associated with age at menarche and breast cancer risk: a case-control study (Other)"^^ . . . . . . "medium.jpg"^^ . . . "Genetic variation at CYP3A is associated with age at menarche and breast cancer risk: a case-control study (Other)"^^ . . . . . . "small.jpg"^^ . . "HTML Summary of #19475 \n\nGenetic variation at CYP3A is associated with age at menarche and breast cancer risk: a case-control study\n\n" . "text/html" . . . "610 Medizin"@de . "610 Medical sciences Medicine"@en . .