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primary topic: Genetic variation at CYP3A is associated with age at menarche and breast cancer risk: a case-control study

Genetic variation at CYP3A is associated with age at menarche and breast cancer risk: a case-control study
type: AcademicArticle
type: Article
abstract: Introduction: We have previously shown that a tag single nucleotide polymorphism (rs10235235), which maps to the CYP3A locus (7q22.1), was associated with a reduction in premenopausal urinary estrone glucuronide levels and a modest reduction in risk of breast cancer in women age ≤50 years. Methods: We further investigated the association of rs10235235 with breast cancer risk in a large case control study of 47,346 cases and 47,570 controls from 52 studies participating in the Breast Cancer Association Consortium. Genotyping of rs10235235 was conducted using a custom Illumina Infinium array. Stratified analyses were conducted to determine whether this association was modified by age at diagnosis, ethnicity, age at menarche or tumor characteristics. Results: We confirmed the association of rs10235235 with breast cancer risk for women of European ancestry but found no evidence that this association differed with age at diagnosis. Heterozygote and homozygote odds ratios (ORs) were OR = 0.98 (95% CI 0.94, 1.01; P = 0.2) and OR = 0.80 (95% CI 0.69, 0.93; P = 0.004), respectively (P trend = 0.02). There was no evidence of effect modification by tumor characteristics. rs10235235 was, however, associated with age at menarche in controls (P trend = 0.005) but not cases (P trend = 0.97). Consequently the association between rs10235235 and breast cancer risk differed according to age at menarche (P het = 0.02); the rare allele of rs10235235 was associated with a reduction in breast cancer risk for women who had their menarche age ≥15 years (ORhet = 0.84, 95% CI 0.75, 0.94; ORhom = 0.81, 95% CI 0.51, 1.30; P trend = 0.002) but not for those who had their menarche age ≤11 years (ORhet = 1.06, 95% CI 0.95, 1.19, ORhom = 1.07, 95% CI 0.67, 1.72; P trend = 0.29). Conclusions: To our knowledge rs10235235 is the first single nucleotide polymorphism to be associated with both breast cancer risk and age at menarche consistent with the well-documented association between later age at men…
date: 2014
volume: 16
issue: R51
is part of: Breast cancer research
author list: authors
type: EPrint
type: ArticleEPrint
is part of: repository
has document: Genetic variation at CYP3A is associated with age at menarche and breast cancer risk: a case-control study (PDF)
has document: Genetic variation at CYP3A is associated with age at menarche and breast cancer risk: a case-control study (Other)
subject: 610 Medizin

Genetic variation at CYP3A is associated with age at menarche and breast cancer risk: a case-control study (PDF)
type: Document
has file: 13058_2013_Article_3558.pdf
has part: 13058_2013_Article_3558.pdf

BioMed Central
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Breast cancer research
type: Collection
issn: 1465542X

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Genetic variation at CYP3A is associated with age at menarche and breast cancer risk: a case-control study (Other)
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Genetic variation at CYP3A is associated with age at menarche and breast cancer risk: a case-control study (Other)
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is version of: Genetic variation at CYP3A is associated with age at menarche and breast cancer risk: a case-control study (PDF)
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Genetic variation at CYP3A is associated with age at menarche and breast cancer risk: a case-control study (Other)
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Genetic variation at CYP3A is associated with age at menarche and breast cancer risk: a case-control study (Other)
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Genetic variation at CYP3A is associated with age at menarche and breast cancer risk: a case-control study (Other)
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primary topic: Genetic variation at CYP3A is associated with age at menarche and breast cancer risk: a case-control study

610 Medizin
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