TY  - JOUR
SP  - 1
IS  - R51
TI  - Genetic variation at CYP3A is associated with age at menarche and breast cancer risk: a case-control study
A1  - Johnson, Nichola
A1  - Dudbridge, Frank
A1  - Orr, Nick
A1  - Gibson, Lorna
A1  - Jones, Michael E.
A1  - Schoemaker, Minouk J.
A1  - Folkerd, Elizabeth J.
A1  - Haynes, Ben P.
A1  - Hopper, John L.
A1  - Southey, Melissa C.
A1  - Dite, Gillian S.
A1  - Apicella, Carmel
A1  - Schmidt, Marjanka K.
A1  - Broeks, Annegien
A1  - Van?t Veer, Laura J.
A1  - Atsma, Femke
A1  - Muir, Kenneth
A1  - Lophatananon, Artitaya
A1  - Fasching, Peter A.
A1  - Beckmann, Matthias W.
A1  - Ekici, Arif B.
A1  - Renner, Stefan P.
A1  - Sawyer, Elinor
A1  - Tomlinson, Ian
A1  - Kerin, Michael
A1  - Miller, Nicola
A1  - Burwinkel, Barbara
A1  - Marme, Frederik
A1  - Schneeweiß, Andreas
A1  - Sohn, Christof
A1  - Guénel, Pascal
A1  - Truong, Therese
A1  - Cordina, Emilie
A1  - Menegaux, Florence
A1  - Bojesen, Stig E.
A1  - Nordestgaard, Børge G.
A1  - Flyger, Henrik
A1  - Milne, Roger
A1  - Zamora, M. Pilar
A1  - Perez, Jose Ignacio Arias
A1  - Benitez, Javier
A1  - Bernstein, Leslie
A1  - Anton-Culver, Hoda
A1  - Ziogas, Argyrios
A1  - Clarke Dur, Christina
A1  - Brenner, Hermann
A1  - Müller, Heiko
A1  - Arndt, Volker
A1  - Dieffenbach, Aida Karina
A1  - Meindl, Alfons
A1  - Heil, Jörg
A1  - Bartram, Claus R.
A1  - Schmutzler, Rita K.
A1  - Brauch, Hiltrud
A1  - Justenhoven, Christina
A1  - Ko, Yon-Dschun
A1  - Nevanlinna, Heli
A1  - Muranen, Taru A.
A1  - Aittomäki, Kristiina
A1  - Blomqvist, Carl
A1  - Matsuo, Keitaro
A1  - Dörk, Thilo
A1  - Bogdanova, Natalia V.
A1  - Antonenkova, Natalia N.
A1  - Lindblom, Annika
A1  - Mannermaa, Arto
A1  - Kataja, Vesa
A1  - Kosma, Veli-Matti
A1  - Hartikainen, Jaana M
A1  - Chenevix-Trench, Georgia
A1  - Beesley, Jonathan
A1  - Wu, Anna H.
A1  - Van den Berg, David
A1  - Tseng, Chiu-Chen
A1  - Lambrechts, Diether
A1  - Smeets, Dominiek
A1  - Neven, Patrick
A1  - Wildiers, Hans
A1  - Chang-Claude, Jenny
A1  - Rudolph, Anja
A1  - Nickels, Stefan
A1  - Flesch-Janys, Dieter
A1  - Radice, Paolo
A1  - Peterlongo, Paolo
A1  - Bonanni, Bernardo
A1  - Pensotti, Valeria
A1  - Couch, Fergus J.
A1  - Olson, Janet E.
A1  - Wang, Xianshu
A1  - Fredericksen, Zachary
A1  - Pankratz, Vernon S.
A1  - Giles, Graham G.
A1  - Severi, Gianluca
A1  - Baglietto, Laura
A1  - Haiman, Chris
A1  - Simard, Jacques
A1  - Goldberg, Mark S
A1  - Labrèche, France
A1  - Dumont, Martine
A1  - Soucy, Penny
A1  - Teo, Soo
A1  - Yip, Cheng Har
A1  - Phuah, Sze Yee
A1  - Cornes, Belinda K.
A1  - Kristensen, Vessela N.
A1  - Grenaker Alnæs, Grethe
A1  - Børresen-Dale, Anne-Lise
A1  - Zheng, Wei
A1  - Winqvist, Robert
A1  - Pylkäs, Katri
A1  - Jukkola-Vuorinen, Arja
A1  - Grip, Mervi
A1  - Andrulis, Irene L.
A1  - Knight, Julia A.
A1  - Glendon, Gord
A1  - Mulligan, Anna Marie
A1  - Devillee, Peter
A1  - Figueroa, Jonine
A1  - Chanock, Stephen J.
A1  - Lissowska, Jolanta
A1  - Sherman, Mark E
A1  - Hall, Per
A1  - Schoof, Nils
A1  - Hooning, Maartje
A1  - Hollestelle, Antoinette
A1  - Oldenburg, Rogier A.
A1  - Tilanus-Linthorst, Madeleine
A1  - Liu, Jianjun
A1  - Cox, Angie
A1  - Brock, Ian W.
A1  - Reed, Malcolm WR
A1  - Cross, Simon S.
A1  - Blot, William
A1  - Signorello, Lisa B.
A1  - Pharoah, Paul DP
A1  - Dunning, Alison M.
A1  - Shah, Mitul
A1  - Kang, Daehee
A1  - Noh, Dong-Young
A1  - Park, Sue K.
A1  - Choi, Ji-Yeob
A1  - Hartman, Mikael
A1  - Miao, Hui
A1  - Lim, Wei Yen
A1  - Tang, Anthony
A1  - Hamann, Ute
A1  - Försti, Asta
A1  - Rüdiger, Thomas
A1  - Ulmer, Hans U.
A1  - Jakubowska, Anna
A1  - Lubinski, Jan
A1  - Jaworska-Bieniek, Katarzyna
A1  - Durda, Katarzyna
A1  - Sangrajrang, Suleeporn
A1  - Gaborieau, Valerie
A1  - Brennan, Paul
A1  - McKay, James
A1  - Slager, Susan
A1  - Toland, Amanda E
A1  - Vachon, Celine
A1  - Yannoukakos, Drakoulis
A1  - Shen, Chen-Yang
A1  - Yu, Jyh-Cherng
A1  - Huang, Chiun-Sheng
A1  - Hou, Ming-Feng
A1  - González-Neira, Anna
A1  - Tessier, Daniel C.
A1  - Vincent, Daniel
A1  - Bacot, Francois
A1  - Luccarini, Craig
A1  - Dennis, Joe
A1  - Michailidou, Kyriaki
A1  - Bolla, Manjeet K.
A1  - Wang, Jean
A1  - Easton, Douglas F.
A1  - García-Closas, Montserrat
A1  - Dowsett, Mitch
A1  - Ashworth, Alan
A1  - Swerdlow, Anthony J.
A1  - Peto, Julian
A1  - dos Santos Silva, Isabel
A1  - Fletcher, Olivia
PB  - BioMed Central
SN  - 1465-542X
JF  - Breast cancer research
ID  - heidok19475
UR  - https://archiv.ub.uni-heidelberg.de/volltextserver/19475/
Y1  - 2014///
EP  - 13
AV  - public
CY  - London
VL  - 16
N2  - Introduction: We have previously shown that a tag single nucleotide polymorphism (rs10235235), which maps to the CYP3A locus (7q22.1), was associated with a reduction in premenopausal urinary estrone glucuronide levels and a modest reduction in risk of breast cancer in women age ?50 years.   Methods: We further investigated the association of rs10235235 with breast cancer risk in a large case control study of 47,346 cases and 47,570 controls from 52 studies participating in the Breast Cancer Association Consortium. Genotyping of rs10235235 was conducted using a custom Illumina Infinium array. Stratified analyses were conducted to determine whether this association was modified by age at diagnosis, ethnicity, age at menarche or tumor characteristics.   Results: We confirmed the association of rs10235235 with breast cancer risk for women of European ancestry but found no evidence that this association differed with age at diagnosis. Heterozygote and homozygote odds ratios (ORs) were OR = 0.98 (95% CI 0.94, 1.01; P = 0.2) and OR = 0.80 (95% CI 0.69, 0.93; P = 0.004), respectively (P trend = 0.02). There was no evidence of effect modification by tumor characteristics. rs10235235 was, however, associated with age at menarche in controls (P trend = 0.005) but not cases (P trend = 0.97). Consequently the association between rs10235235 and breast cancer risk differed according to age at menarche (P het = 0.02); the rare allele of rs10235235 was associated with a reduction in breast cancer risk for women who had their menarche age ?15 years (ORhet = 0.84, 95% CI 0.75, 0.94; ORhom = 0.81, 95% CI 0.51, 1.30; P trend = 0.002) but not for those who had their menarche age ?11 years (ORhet = 1.06, 95% CI 0.95, 1.19, ORhom = 1.07, 95% CI 0.67, 1.72; P trend = 0.29).   Conclusions: To our knowledge rs10235235 is the first single nucleotide polymorphism to be associated with both breast cancer risk and age at menarche consistent with the well-documented association between later age at menarche and a reduction in breast cancer risk. These associations are likely mediated via an effect on circulating hormone levels.  
ER  -