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creators_name: Johnson, Nichola
creators_name: Dudbridge, Frank
creators_name: Orr, Nick
creators_name: Gibson, Lorna
creators_name: Jones, Michael E.
creators_name: Schoemaker, Minouk J.
creators_name: Folkerd, Elizabeth J.
creators_name: Haynes, Ben P.
creators_name: Hopper, John L.
creators_name: Southey, Melissa C.
creators_name: Dite, Gillian S.
creators_name: Apicella, Carmel
creators_name: Schmidt, Marjanka K.
creators_name: Broeks, Annegien
creators_name: Van’t Veer, Laura J.
creators_name: Atsma, Femke
creators_name: Muir, Kenneth
creators_name: Lophatananon, Artitaya
creators_name: Fasching, Peter A.
creators_name: Beckmann, Matthias W.
creators_name: Ekici, Arif B.
creators_name: Renner, Stefan P.
creators_name: Sawyer, Elinor
creators_name: Tomlinson, Ian
creators_name: Kerin, Michael
creators_name: Miller, Nicola
creators_name: Burwinkel, Barbara
creators_name: Marme, Frederik
creators_name: Schneeweiß, Andreas
creators_name: Sohn, Christof
creators_name: Guénel, Pascal
creators_name: Truong, Therese
creators_name: Cordina, Emilie
creators_name: Menegaux, Florence
creators_name: Bojesen, Stig E.
creators_name: Nordestgaard, Børge G.
creators_name: Flyger, Henrik
creators_name: Milne, Roger
creators_name: Zamora, M. Pilar
creators_name: Perez, Jose Ignacio Arias
creators_name: Benitez, Javier
creators_name: Bernstein, Leslie
creators_name: Anton-Culver, Hoda
creators_name: Ziogas, Argyrios
creators_name: Clarke Dur, Christina
creators_name: Brenner, Hermann
creators_name: Müller, Heiko
creators_name: Arndt, Volker
creators_name: Dieffenbach, Aida Karina
creators_name: Meindl, Alfons
creators_name: Heil, Jörg
creators_name: Bartram, Claus R.
creators_name: Schmutzler, Rita K.
creators_name: Brauch, Hiltrud
creators_name: Justenhoven, Christina
creators_name: Ko, Yon-Dschun
creators_name: Nevanlinna, Heli
creators_name: Muranen, Taru A.
creators_name: Aittomäki, Kristiina
creators_name: Blomqvist, Carl
creators_name: Matsuo, Keitaro
creators_name: Dörk, Thilo
creators_name: Bogdanova, Natalia V.
creators_name: Antonenkova, Natalia N.
creators_name: Lindblom, Annika
creators_name: Mannermaa, Arto
creators_name: Kataja, Vesa
creators_name: Kosma, Veli-Matti
creators_name: Hartikainen, Jaana M
creators_name: Chenevix-Trench, Georgia
creators_name: Beesley, Jonathan
creators_name: Wu, Anna H.
creators_name: Van den Berg, David
creators_name: Tseng, Chiu-Chen
creators_name: Lambrechts, Diether
creators_name: Smeets, Dominiek
creators_name: Neven, Patrick
creators_name: Wildiers, Hans
creators_name: Chang-Claude, Jenny
creators_name: Rudolph, Anja
creators_name: Nickels, Stefan
creators_name: Flesch-Janys, Dieter
creators_name: Radice, Paolo
creators_name: Peterlongo, Paolo
creators_name: Bonanni, Bernardo
creators_name: Pensotti, Valeria
creators_name: Couch, Fergus J.
creators_name: Olson, Janet E.
creators_name: Wang, Xianshu
creators_name: Fredericksen, Zachary
creators_name: Pankratz, Vernon S.
creators_name: Giles, Graham G.
creators_name: Severi, Gianluca
creators_name: Baglietto, Laura
creators_name: Haiman, Chris
creators_name: Simard, Jacques
creators_name: Goldberg, Mark S
creators_name: Labrèche, France
creators_name: Dumont, Martine
creators_name: Soucy, Penny
creators_name: Teo, Soo
creators_name: Yip, Cheng Har
creators_name: Phuah, Sze Yee
creators_name: Cornes, Belinda K.
creators_name: Kristensen, Vessela N.
creators_name: Grenaker Alnæs, Grethe
creators_name: Børresen-Dale, Anne-Lise
creators_name: Zheng, Wei
creators_name: Winqvist, Robert
creators_name: Pylkäs, Katri
creators_name: Jukkola-Vuorinen, Arja
creators_name: Grip, Mervi
creators_name: Andrulis, Irene L.
creators_name: Knight, Julia A.
creators_name: Glendon, Gord
creators_name: Mulligan, Anna Marie
creators_name: Devillee, Peter
creators_name: Figueroa, Jonine
creators_name: Chanock, Stephen J.
creators_name: Lissowska, Jolanta
creators_name: Sherman, Mark E
creators_name: Hall, Per
creators_name: Schoof, Nils
creators_name: Hooning, Maartje
creators_name: Hollestelle, Antoinette
creators_name: Oldenburg, Rogier A.
creators_name: Tilanus-Linthorst, Madeleine
creators_name: Liu, Jianjun
creators_name: Cox, Angie
creators_name: Brock, Ian W.
creators_name: Reed, Malcolm WR
creators_name: Cross, Simon S.
creators_name: Blot, William
creators_name: Signorello, Lisa B.
creators_name: Pharoah, Paul DP
creators_name: Dunning, Alison M.
creators_name: Shah, Mitul
creators_name: Kang, Daehee
creators_name: Noh, Dong-Young
creators_name: Park, Sue K.
creators_name: Choi, Ji-Yeob
creators_name: Hartman, Mikael
creators_name: Miao, Hui
creators_name: Lim, Wei Yen
creators_name: Tang, Anthony
creators_name: Hamann, Ute
creators_name: Försti, Asta
creators_name: Rüdiger, Thomas
creators_name: Ulmer, Hans U.
creators_name: Jakubowska, Anna
creators_name: Lubinski, Jan
creators_name: Jaworska-Bieniek, Katarzyna
creators_name: Durda, Katarzyna
creators_name: Sangrajrang, Suleeporn
creators_name: Gaborieau, Valerie
creators_name: Brennan, Paul
creators_name: McKay, James
creators_name: Slager, Susan
creators_name: Toland, Amanda E
creators_name: Vachon, Celine
creators_name: Yannoukakos, Drakoulis
creators_name: Shen, Chen-Yang
creators_name: Yu, Jyh-Cherng
creators_name: Huang, Chiun-Sheng
creators_name: Hou, Ming-Feng
creators_name: González-Neira, Anna
creators_name: Tessier, Daniel C.
creators_name: Vincent, Daniel
creators_name: Bacot, Francois
creators_name: Luccarini, Craig
creators_name: Dennis, Joe
creators_name: Michailidou, Kyriaki
creators_name: Bolla, Manjeet K.
creators_name: Wang, Jean
creators_name: Easton, Douglas F.
creators_name: García-Closas, Montserrat
creators_name: Dowsett, Mitch
creators_name: Ashworth, Alan
creators_name: Swerdlow, Anthony J.
creators_name: Peto, Julian
creators_name: dos Santos Silva, Isabel
creators_name: Fletcher, Olivia
title: Genetic variation at CYP3A is associated with age at menarche and breast cancer risk: a case-control study
subjects: 610
divisions: 850300
divisions: 851600
divisions: 910400
divisions: 911500
abstract: Introduction: We have previously shown that a tag single nucleotide polymorphism (rs10235235), which maps to the CYP3A locus (7q22.1), was associated with a reduction in premenopausal urinary estrone glucuronide levels and a modest reduction in risk of breast cancer in women age ≤50 years.   Methods: We further investigated the association of rs10235235 with breast cancer risk in a large case control study of 47,346 cases and 47,570 controls from 52 studies participating in the Breast Cancer Association Consortium. Genotyping of rs10235235 was conducted using a custom Illumina Infinium array. Stratified analyses were conducted to determine whether this association was modified by age at diagnosis, ethnicity, age at menarche or tumor characteristics.   Results: We confirmed the association of rs10235235 with breast cancer risk for women of European ancestry but found no evidence that this association differed with age at diagnosis. Heterozygote and homozygote odds ratios (ORs) were OR = 0.98 (95% CI 0.94, 1.01; P = 0.2) and OR = 0.80 (95% CI 0.69, 0.93; P = 0.004), respectively (P trend = 0.02). There was no evidence of effect modification by tumor characteristics. rs10235235 was, however, associated with age at menarche in controls (P trend = 0.005) but not cases (P trend = 0.97). Consequently the association between rs10235235 and breast cancer risk differed according to age at menarche (P het = 0.02); the rare allele of rs10235235 was associated with a reduction in breast cancer risk for women who had their menarche age ≥15 years (ORhet = 0.84, 95% CI 0.75, 0.94; ORhom = 0.81, 95% CI 0.51, 1.30; P trend = 0.002) but not for those who had their menarche age ≤11 years (ORhet = 1.06, 95% CI 0.95, 1.19, ORhom = 1.07, 95% CI 0.67, 1.72; P trend = 0.29).   Conclusions: To our knowledge rs10235235 is the first single nucleotide polymorphism to be associated with both breast cancer risk and age at menarche consistent with the well-documented association between later age at menarche and a reduction in breast cancer risk. These associations are likely mediated via an effect on circulating hormone levels.  
date: 2014
publisher: BioMed Central
id_scheme: DOI
ppn_swb: 1656159376
own_urn: urn:nbn:de:bsz:16-heidok-194755
language: eng
bibsort: JOHNSONNICGENETICVAR2014
full_text_status: public
publication: Breast cancer research
volume: 16
number: R51
place_of_pub: London
pagerange: 1-13
issn: 1465-542X
citation:   Johnson, Nichola ; Dudbridge, Frank ; Orr, Nick ; Gibson, Lorna ; Jones, Michael E. ; Schoemaker, Minouk J. ; Folkerd, Elizabeth J. ; Haynes, Ben P. ; Hopper, John L. ; Southey, Melissa C. ; Dite, Gillian S. ; Apicella, Carmel ; Schmidt, Marjanka K. ; Broeks, Annegien ; Van’t Veer, Laura J. ; Atsma, Femke ; Muir, Kenneth ; Lophatananon, Artitaya ; Fasching, Peter A. ; Beckmann, Matthias W. ; Ekici, Arif B. ; Renner, Stefan P. ; Sawyer, Elinor ; Tomlinson, Ian ; Kerin, Michael ; Miller, Nicola ; Burwinkel, Barbara ; Marme, Frederik ; Schneeweiß, Andreas ; Sohn, Christof ; Guénel, Pascal ; Truong, Therese ; Cordina, Emilie ; Menegaux, Florence ; Bojesen, Stig E. ; Nordestgaard, Børge G. ; Flyger, Henrik ; Milne, Roger ; Zamora, M. Pilar ; Perez, Jose Ignacio Arias ; Benitez, Javier ; Bernstein, Leslie ; Anton-Culver, Hoda ; Ziogas, Argyrios ; Clarke Dur, Christina ; Brenner, Hermann ; Müller, Heiko ; Arndt, Volker ; Dieffenbach, Aida Karina ; Meindl, Alfons ; Heil, Jörg ; Bartram, Claus R. ; Schmutzler, Rita K. ; Brauch, Hiltrud ; Justenhoven, Christina ; Ko, Yon-Dschun ; Nevanlinna, Heli ; Muranen, Taru A. ; Aittomäki, Kristiina ; Blomqvist, Carl ; Matsuo, Keitaro ; Dörk, Thilo ; Bogdanova, Natalia V. ; Antonenkova, Natalia N. ; Lindblom, Annika ; Mannermaa, Arto ; Kataja, Vesa ; Kosma, Veli-Matti ; Hartikainen, Jaana M ; Chenevix-Trench, Georgia ; Beesley, Jonathan ; Wu, Anna H. ; Van den Berg, David ; Tseng, Chiu-Chen ; Lambrechts, Diether ; Smeets, Dominiek ; Neven, Patrick ; Wildiers, Hans ; Chang-Claude, Jenny ; Rudolph, Anja ; Nickels, Stefan ; Flesch-Janys, Dieter ; Radice, Paolo ; Peterlongo, Paolo ; Bonanni, Bernardo ; Pensotti, Valeria ; Couch, Fergus J. ; Olson, Janet E. ; Wang, Xianshu ; Fredericksen, Zachary ; Pankratz, Vernon S. ; Giles, Graham G. ; Severi, Gianluca ; Baglietto, Laura ; Haiman, Chris ; Simard, Jacques ; Goldberg, Mark S ; Labrèche, France ; Dumont, Martine ; Soucy, Penny ; Teo, Soo ; Yip, Cheng Har ; Phuah, Sze Yee ; Cornes, Belinda K. ; Kristensen, Vessela N. ; Grenaker Alnæs, Grethe ; Børresen-Dale, Anne-Lise ; Zheng, Wei ; Winqvist, Robert ; Pylkäs, Katri ; Jukkola-Vuorinen, Arja ; Grip, Mervi ; Andrulis, Irene L. ; Knight, Julia A. ; Glendon, Gord ; Mulligan, Anna Marie ; Devillee, Peter ; Figueroa, Jonine ; Chanock, Stephen J. ; Lissowska, Jolanta ; Sherman, Mark E ; Hall, Per ; Schoof, Nils ; Hooning, Maartje ; Hollestelle, Antoinette ; Oldenburg, Rogier A. ; Tilanus-Linthorst, Madeleine ; Liu, Jianjun ; Cox, Angie ; Brock, Ian W. ; Reed, Malcolm WR ; Cross, Simon S. ; Blot, William ; Signorello, Lisa B. ; Pharoah, Paul DP ; Dunning, Alison M. ; Shah, Mitul ; Kang, Daehee ; Noh, Dong-Young ; Park, Sue K. ; Choi, Ji-Yeob ; Hartman, Mikael ; Miao, Hui ; Lim, Wei Yen ; Tang, Anthony ; Hamann, Ute ; Försti, Asta ; Rüdiger, Thomas ; Ulmer, Hans U. ; Jakubowska, Anna ; Lubinski, Jan ; Jaworska-Bieniek, Katarzyna ; Durda, Katarzyna ; Sangrajrang, Suleeporn ; Gaborieau, Valerie ; Brennan, Paul ; McKay, James ; Slager, Susan ; Toland, Amanda E ; Vachon, Celine ; Yannoukakos, Drakoulis ; Shen, Chen-Yang ; Yu, Jyh-Cherng ; Huang, Chiun-Sheng ; Hou, Ming-Feng ; González-Neira, Anna ; Tessier, Daniel C. ; Vincent, Daniel ; Bacot, Francois ; Luccarini, Craig ; Dennis, Joe ; Michailidou, Kyriaki ; Bolla, Manjeet K. ; Wang, Jean ; Easton, Douglas F. ; García-Closas, Montserrat ; Dowsett, Mitch ; Ashworth, Alan ; Swerdlow, Anthony J. ; Peto, Julian ; dos Santos Silva, Isabel ; Fletcher, Olivia  (2014) Genetic variation at CYP3A is associated with age at menarche and breast cancer risk: a case-control study.  Breast cancer research, 16 (R51).  pp. 1-13.  ISSN 1465-542X     
document_url: https://archiv.ub.uni-heidelberg.de/volltextserver/19475/1/13058_2013_Article_3558.pdf