<> "The repository administrator has not yet configured an RDF license."^^ . <> . . . "The influence of obesity on survival in early, high-risk breast cancer: results from the randomized SUCCESS A trial"^^ . "Introduction: Obese breast cancer patients have worse prognosis than normal weight patients, but the level at which obesity is prognostically unfavorable is unclear. Methods: This retrospective analysis was performed using data from the SUCCESS A trial, in which 3754 patients with high-risk early breast cancer were randomized to anthracycline- and taxane-based chemotherapy with or without gemcitabine. Patients were classified as underweight/normal weight (body mass index (BMI) < 25.0), overweight (BMI 25.0–29.9), slightly obese (BMI 30.0–34.9), moderately obese (BMI 35.0–39.9) and severely obese (BMI ≥ 40.0), and the effect of BMI on disease-free survival (DFS) and overall survival (OS) was evaluated (median follow-up 65 months). In addition, subgroup analyses were conducted to assess the effect of BMI in luminal A-like, luminal B-like, HER2 (human epidermal growth factor 2)-positive and triple-negative tumors. Results: Multivariate analyses revealed an independent prognostic effect of BMI on DFS (p = 0.001) and OS (p = 0.005). Compared with underweight/normal weight patients, severely obese patients had worse DFS (hazard ratio (HR) 2.70, 95 % confidence interval (CI) 1.71–4.28, p < 0.001) and OS (HR 2.79, 95 % CI 1.63–4.77, p < 0.001), while moderately obese, slightly obese and overweight patients did not differ from underweight/normal weight patients with regard to DFS or OS. Subgroup analyses showed a similar significant effect of BMI on DFS and OS in patients with triple-negative breast cancer (TNBC), but not in patients with other tumor subtypes. Conclusions: Severe obesity (BMI ≥ 40) significantly worsens prognosis in early breast cancer patients, particularly for triple-negative tumors. Trial registration: Clinicaltrials.gov NCT02181101. Registered September 2005 "^^ . "2015" . . "17" . "129" . . "BioMed Central"^^ . . . "Breast Cancer Research"^^ . . . "1465542X" . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . "Thomas WP"^^ . "Friedl"^^ . "Thomas WP Friedl"^^ . . "Nikolaus"^^ . "DeGregorio"^^ . "Nikolaus DeGregorio"^^ . . "Brigitte"^^ . "Rack"^^ . "Brigitte Rack"^^ . . "Inga"^^ . "Bekes"^^ . "Inga Bekes"^^ . . "Bernd"^^ . "Kost"^^ . "Bernd Kost"^^ . . "Elisabeth"^^ . "Trapp"^^ . "Elisabeth Trapp"^^ . . "Miriam"^^ . "Deniz"^^ . "Miriam Deniz"^^ . . "Lukas"^^ . "Schwentner"^^ . "Lukas Schwentner"^^ . . "Ulrich"^^ . "Andergassen"^^ . "Ulrich Andergassen"^^ . . "Andreas"^^ . "Schneeweiß"^^ . "Andreas Schneeweiß"^^ . . "Tobias"^^ . "Weissenbacher"^^ . "Tobias Weissenbacher"^^ . . "Peter"^^ . "Widschwendter"^^ . "Peter Widschwendter"^^ . . "Ines"^^ . "Schrader"^^ . "Ines Schrader"^^ . . "Peter A."^^ . "Fasching"^^ . "Peter A. Fasching"^^ . . "Bernadette"^^ . "Jäger"^^ . "Bernadette Jäger"^^ . . "Amelie"^^ . "Schramm"^^ . "Amelie Schramm"^^ . . "Christoph"^^ . "Scholz"^^ . "Christoph Scholz"^^ . . "Julia"^^ . "Neugebauer"^^ . "Julia Neugebauer"^^ . . "Julia"^^ . "Jückstock"^^ . "Julia Jückstock"^^ . . "Krisztian"^^ . "Lato"^^ . "Krisztian Lato"^^ . . "Wolfgang"^^ . "Janni"^^ . "Wolfgang Janni"^^ . . "Matthias W."^^ . "Beckmann"^^ . "Matthias W. Beckmann"^^ . . . . . . "The influence of obesity on survival in early, high-risk breast cancer: results from the randomized SUCCESS A trial (PDF)"^^ . . . "13058_2015_Article_639.pdf"^^ . . . "The influence of obesity on survival in early, high-risk breast cancer: results from the randomized SUCCESS A trial (Other)"^^ . . . . . . "lightbox.jpg"^^ . . . "The influence of obesity on survival in early, high-risk breast cancer: results from the randomized SUCCESS A trial (Other)"^^ . . . . . . "preview.jpg"^^ . . . "The influence of obesity on survival in early, high-risk breast cancer: results from the randomized SUCCESS A trial (Other)"^^ . . . . . . "medium.jpg"^^ . . . "The influence of obesity on survival in early, high-risk breast cancer: results from the randomized SUCCESS A trial (Other)"^^ . . . . . . "small.jpg"^^ . . . "The influence of obesity on survival in early, high-risk breast cancer: results from the randomized SUCCESS A trial (Other)"^^ . . . . . . "indexcodes.txt"^^ . . "HTML Summary of #19487 \n\nThe influence of obesity on survival in early, high-risk breast cancer: results from the randomized SUCCESS A trial\n\n" . "text/html" . . . "610 Medizin"@de . "610 Medical sciences Medicine"@en . .