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primary topic: Effects of inosine on reperfusion injury after cardiopulmonary bypass

Effects of inosine on reperfusion injury after cardiopulmonary bypass
type: AcademicArticle
type: Article
abstract: Objective: Inosine, a break-down product of adenosine has been recently shown to exert inodilatory and anti-inflammatory properties. Furthermore inosine might be a key substrate of pharmacological post-conditioning. In the present pre-clinical study, we investigated the effects of inosine on cardiac function during reperfusion in an experimental model of cardioplegic arrest and extracorporal circulation. Methods: Twelve anesthetized dogs underwent hypothermic cardiopulmonary bypass. After 60 minutes of hypothermic cardiac arrest, reperfusion was started after application of either saline vehicle (control, n = 6), or inosine (100 mg/kg, n = 6). Left ventricular end-systolic pressure volume relationship (ESPVR) was measured by a combined pressure-volume-conductance catheter at baseline and after 60 minutes of reperfusion. Left anterior descendent coronary blood flow (CBF), endothelium-dependent vasodilatation to acetylcholine (ACh) and endothelium-independent vasodilatation to sodium nitroprusside (SNP) were also determined. Results: The administration of inosine led to a significantly better recovery (given as percent of baseline) of ESPVR 90 ± 9% vs. 46 ± 6%, p < 0.05. CBF and was also significantly higher in the inosine group (56 ± 8 vs. 23 ± 4, ml/min, p < 0.05). While the vasodilatatory response to SNP was similar in both groups, ACh resulted in a significantly higher increase in CBF (58 ± 6% vs. 25 ± 5%, p < 0.05) in the inosine group. Conclusions: Application of inosine improves myocardial and endothelial function after cardiopulmonary bypass with hypothermic cardiac arrest.
date: 2010
volume: 5
issue: 106
is part of: Journal of Cardiothoracic Surgery
author list: authors
type: EPrint
type: ArticleEPrint
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has document: Effects of inosine on reperfusion injury after cardiopulmonary bypass (PDF)
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subject: 610 Medizin

Effects of inosine on reperfusion injury after cardiopulmonary bypass (PDF)
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has file: 13019_2010_Article_338.pdf
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BioMed Central
type: Organization

Journal of Cardiothoracic Surgery
type: Collection
issn: 17498090

Matthias Karck
type: Person
given name: Matthias
family name: Karck

Leila Seres
type: Person
given name: Leila
family name: Seres

Gábor Szabó
type: Person
given name: Gábor
family name: Szabó

Ferenc Horkay
type: Person
given name: Ferenc
family name: Horkay

Tamás Radovits
type: Person
given name: Tamás
family name: Radovits

Gábor Veres
type: Person
given name: Gábor
family name: Veres

Effects of inosine on reperfusion injury after cardiopulmonary bypass (Other)
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Effects of inosine on reperfusion injury after cardiopulmonary bypass (Other)
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primary topic: Effects of inosine on reperfusion injury after cardiopulmonary bypass

610 Medizin
type: Concept
preferred label: 610 Medical sciences Medicine @en