eprintid: 19570
rev_number: 21
eprint_status: archive
userid: 2101
dir: disk0/00/01/95/70
datestamp: 2015-10-15 08:14:15
lastmod: 2016-11-09 14:26:34
status_changed: 2015-10-15 08:14:15
type: doctoralThesis
metadata_visibility: show
creators_name: Albert, Philipp
title: Modeling Cell Dynamics on Micropatterned Substrates with a Cellular Potts Model
subjects: ddc-500
subjects: ddc-530
subjects: ddc-570
divisions: i-130300
adv_faculty: af-13
abstract: Tools from materials science are increasingly used to decrease the variability that often limits the quantitative analysis of cell experiments. Most prominently, micropatterned substrates can be used to normalize cell shape and internal organization. For long-term experiments, however, cells must be able to divide and migrate. This creates the need to design networks of micropatterns that ensure normalization to be maintained even in a dynamic context. The design of such networks requires an efficient model predicting the degree of normalization for dividing and migrating cells. Here we extend earlier formulations of the two-dimensional cellular Potts model with the aim to achieve good agreement with existing cell experiments on cell shape and forces on micropatterns. We show that our model correctly predicts cell spreading, division and migration on micropatterns, both for single cells and cell communities. The inverse problem of network optimization is then addressed with genetic algorithms.
date: 2015
id_scheme: DOI
id_number: 10.11588/heidok.00019570
ppn_swb: 1653757663
own_urn: urn:nbn:de:bsz:16-heidok-195706
date_accepted: 2015-05-27
advisor: HASH(0x559e37da6d38)
language: eng
bibsort: ALBERTPHILMODELINGCE2015
full_text_status: public
citation:   Albert, Philipp  (2015) Modeling Cell Dynamics on Micropatterned Substrates with a Cellular Potts Model.  [Dissertation]     
document_url: https://archiv.ub.uni-heidelberg.de/volltextserver/19570/1/main_print.pdf