<> "The repository administrator has not yet configured an RDF license."^^ . <> . . . "Behavioral phenotype in five individuals with de novo mutations within the GRIN2B gene"^^ . "Background: Intellectual disability (ID) is often associated with behavioral problems or disorders. Mutations in the GRIN2B gene (MRD6, MIM613970) have been identified as a common cause of ID (prevalence of 0.5 – 1% in individuals with ID) associated with EEG and behavioral problems. Methods: We assessed five GRIN2B mutation carriers aged between 3 and 14 years clinically and via standardized questionnaires to delineate a detailed behavioral phenotype. Parents and teachers rated problem behavior of their affected children by completing the Developmental Behavior Checklist (DBC) and the Conners’ Rating Scales Revised (CRS-R:L). Results: All individuals had mild to severe ID and needed guidance in daily routine. They showed characteristic behavior problems with prominent hyperactivity, impulsivity, distractibility and a short attention span. Stereotypies, sleeping problems and a friendly but boundless social behavior were commonly reported. Conclusion: Our observations provide an initial delineation of the behavioral phenotype of GRIN2B mutation carriers. "^^ . "2013" . . "9" . "20" . . "BioMed Central"^^ . . . "Behavioral and Brain Functions"^^ . . . "17449081" . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . "Dagmar"^^ . "Wieczorek"^^ . "Dagmar Wieczorek"^^ . . "Sabine"^^ . "Endele"^^ . "Sabine Endele"^^ . . "Ute"^^ . "Moog"^^ . "Ute Moog"^^ . . "Holger"^^ . "Petri"^^ . "Holger Petri"^^ . . "Johannes"^^ . "Hebebrand"^^ . "Johannes Hebebrand"^^ . . "Rainer"^^ . "Blank"^^ . "Rainer Blank"^^ . . "Bernhard"^^ . "Zabel"^^ . "Bernhard Zabel"^^ . . "Eva-Christina"^^ . "Prott"^^ . "Eva-Christina Prott"^^ . . "Bernt"^^ . "Popp"^^ . "Bernt Popp"^^ . . "Andre"^^ . "Reis"^^ . "Andre Reis"^^ . . "Inga"^^ . "Freunscht"^^ . "Inga Freunscht"^^ . . "Jochen"^^ . "Rübo"^^ . "Jochen Rübo"^^ . . "Martin"^^ . "Zenker"^^ . "Martin Zenker"^^ . . . . . . "Behavioral phenotype in five individuals with de novo mutations within the GRIN2B gene (Other)"^^ . . . . . . "preview.jpg"^^ . . . "Behavioral phenotype in five individuals with de novo mutations within the GRIN2B gene (Other)"^^ . . . . . . "medium.jpg"^^ . . . "Behavioral phenotype in five individuals with de novo mutations within the GRIN2B gene (Other)"^^ . . . . . . "lightbox.jpg"^^ . . . "Behavioral phenotype in five individuals with de novo mutations within the GRIN2B gene (Other)"^^ . . . . . . "small.jpg"^^ . . . "Behavioral phenotype in five individuals with de novo mutations within the GRIN2B gene (Other)"^^ . . . . . . "indexcodes.txt"^^ . . . "Behavioral phenotype in five individuals with de novo mutations within the GRIN2B gene (PDF)"^^ . . . "12993_2012_Article_455.pdf"^^ . . "HTML Summary of #19724 \n\nBehavioral phenotype in five individuals with de novo mutations within the GRIN2B gene\n\n" . "text/html" . . . "570 Biowissenschaften, Biologie"@de . "570 Life sciences"@en . . . "610 Medizin"@de . "610 Medical sciences Medicine"@en . .