<> "The repository administrator has not yet configured an RDF license."^^ . <> . . . "Optimization of carbon ion and proton treatment plans using the raster-scanning technique for patients with unresectable pancreatic cancer"^^ . "Background: The aim of the thesis is to improve radiation plans of patients with locally advanced, unresectable pancreatic cancer by using carbon ion and proton beams. Patients and methods: Using the treatment planning system Syngo RT Planning (Siemens, Erlangen, Germany) a total of 50 treatment plans have been created for five patients with the dose schedule 15 × 3 Gy(RBE). With reference to the anatomy, five field configurations were considered to be relevant. The plans were analyzed with respect to dose distribution and individual anatomy, and compared using a customized index. Results: Within the index the three-field configurations yielded the best results, though with a high variety of score points (field setup 5, carbon ion: median 74 (range 48–101)). The maximum dose in the myelon is low (e.g. case 3, carbon ion: 21.5 Gy(RBE)). A single posterior field generally spares the organs at risk, but the maximum dose in the myelon is high (e.g. case 3, carbon ion: 32.9 Gy(RBE)). Two oblique posterior fields resulted in acceptable maximum doses in the myelon (e.g. case 3, carbon ion: 26.9 Gy(RBE)). The single-field configuration and the two oblique posterior fields had a small score dispersion (carbon ion: median 66 and 58 (range 62–72 and 40–69)). In cases with topographic proximity of the organs at risk to the target volume, the single-field configuration scored as well as the three-field configurations. Conclusion: In summary, the three-field configurations showed the best dose distributions. A single posterior field seems to be robust and beneficial in case of difficult topographical conditions and topographical proximity of organs at risk to the target volume. A setup with two oblique posterior fields is a reasonable compromise between three-field and single-field configurations."^^ . "2015" . . "10" . "237" . . "BioMed Central"^^ . . . "Radiation Oncology"^^ . . . "1748717X" . . . . . . . . . . . . . . . . . . . . . . . . . . "Oliver"^^ . "Jäkel"^^ . "Oliver Jäkel"^^ . . "Rami"^^ . "El-Shafie"^^ . "Rami El-Shafie"^^ . . "Jürgen"^^ . "Debus"^^ . "Jürgen Debus"^^ . . "Stephan"^^ . "Brons"^^ . "Stephan Brons"^^ . . "Daniel"^^ . "Habermehl"^^ . "Daniel Habermehl"^^ . . "Constantin"^^ . "Dreher"^^ . "Constantin Dreher"^^ . . "Stephanie E."^^ . "Combs"^^ . "Stephanie E. Combs"^^ . . "Swantje"^^ . "Ecker"^^ . "Swantje Ecker"^^ . . . . . . "Optimization of carbon ion and proton treatment plans using the raster-scanning technique for patients with unresectable pancreatic cancer (Other)"^^ . . . . . . "preview.jpg"^^ . . . "Optimization of carbon ion and proton treatment plans using the raster-scanning technique for patients with unresectable pancreatic cancer (Other)"^^ . . . . . . "small.jpg"^^ . . . "Optimization of carbon ion and proton treatment plans using the raster-scanning technique for patients with unresectable pancreatic cancer (Other)"^^ . . . . . . "medium.jpg"^^ . . . "Optimization of carbon ion and proton treatment plans using the raster-scanning technique for patients with unresectable pancreatic cancer (PDF)"^^ . . . "13014_2015_Article_538.pdf"^^ . . . "Optimization of carbon ion and proton treatment plans using the raster-scanning technique for patients with unresectable pancreatic cancer (Other)"^^ . . . . . . "lightbox.jpg"^^ . . . "Optimization of carbon ion and proton treatment plans using the raster-scanning technique for patients with unresectable pancreatic cancer (Other)"^^ . . . . . . "indexcodes.txt"^^ . . "HTML Summary of #19821 \n\nOptimization of carbon ion and proton treatment plans using the raster-scanning technique for patients with unresectable pancreatic cancer\n\n" . "text/html" . . . "610 Medizin"@de . "610 Medical sciences Medicine"@en . .