eprintid: 19821
rev_number: 14
eprint_status: archive
userid: 1589
dir: disk0/00/01/98/21
datestamp: 2016-02-08 13:20:00
lastmod: 2024-03-09 12:41:49
status_changed: 2016-02-08 13:20:00
type: article
metadata_visibility: show
creators_name: Dreher, Constantin
creators_name: Habermehl, Daniel
creators_name: Ecker, Swantje
creators_name: Brons, Stephan
creators_name: El-Shafie, Rami
creators_name: Jäkel, Oliver
creators_name: Debus, Jürgen
creators_name: Combs, Stephanie E.
title: Optimization of carbon ion and proton treatment plans using the raster-scanning technique for patients with unresectable pancreatic cancer
subjects: ddc-610
divisions: i-850300
divisions: i-911400
divisions: i-950400
abstract: Background: The aim of the thesis is to improve radiation plans of patients with locally advanced, unresectable pancreatic cancer by using carbon ion and proton beams.   Patients and methods: Using the treatment planning system Syngo RT Planning (Siemens, Erlangen, Germany) a total of 50 treatment plans have been created for five patients with the dose schedule 15 × 3 Gy(RBE). With reference to the anatomy, five field configurations were considered to be relevant. The plans were analyzed with respect to dose distribution and individual anatomy, and compared using a customized index.   Results: Within the index the three-field configurations yielded the best results, though with a high variety of score points (field setup 5, carbon ion: median 74 (range 48–101)). The maximum dose in the myelon is low (e.g. case 3, carbon ion: 21.5 Gy(RBE)). A single posterior field generally spares the organs at risk, but the maximum dose in the myelon is high (e.g. case 3, carbon ion: 32.9 Gy(RBE)). Two oblique posterior fields resulted in acceptable maximum doses in the myelon (e.g. case 3, carbon ion: 26.9 Gy(RBE)). The single-field configuration and the two oblique posterior fields had a small score dispersion (carbon ion: median 66 and 58 (range 62–72 and 40–69)). In cases with topographic proximity of the organs at risk to the target volume, the single-field configuration scored as well as the three-field configurations.   Conclusion: In summary, the three-field configurations showed the best dose distributions. A single posterior field seems to be robust and beneficial in case of difficult topographical conditions and topographical proximity of organs at risk to the target volume. A setup with two oblique posterior fields is a reasonable compromise between three-field and single-field configurations.
date: 2015
publisher: BioMed Central
id_scheme: DOI
ppn_swb: 1654878073
own_urn: urn:nbn:de:bsz:16-heidok-198210
language: eng
bibsort: DREHERCONSOPTIMIZATI2015
full_text_status: public
publication: Radiation Oncology
volume: 10
number: 237
place_of_pub: London
pagerange: 1-9
issn: 1748-717X
citation:   Dreher, Constantin ; Habermehl, Daniel ; Ecker, Swantje ; Brons, Stephan ; El-Shafie, Rami ; Jäkel, Oliver ; Debus, Jürgen ; Combs, Stephanie E.  (2015) Optimization of carbon ion and proton treatment plans using the raster-scanning technique for patients with unresectable pancreatic cancer.  Radiation Oncology, 10 (237).  pp. 1-9.  ISSN 1748-717X     
document_url: https://archiv.ub.uni-heidelberg.de/volltextserver/19821/1/13014_2015_Article_538.pdf