eprintid: 19919
rev_number: 12
eprint_status: archive
userid: 1589
dir: disk0/00/01/99/19
datestamp: 2016-02-09 08:55:10
lastmod: 2024-06-28 03:23:05
status_changed: 2016-02-09 08:55:10
type: article
metadata_visibility: show
creators_name: Kriegsmann, Mark
creators_name: Muley, Thomas
creators_name: Harms, Alexander
creators_name: Tavernar, Luca
creators_name: Goldmann, Torsten
creators_name: Dienemann, Hendrik
creators_name: Herpel, Esther
creators_name: Warth, Arne
title: Differential diagnostic value of CD5 and CD117 expression in thoracic tumors: A large scale study of 1465 non-small cell lung cancer cases
subjects: ddc-610
divisions: i-912000
divisions: i-950900
abstract: Background: Thoracic pathologists are frequently faced with tissue specimens from intrathoracic/mediastinal tumors. Specifically the differentiation between thymic and pulmonary squamous cell carcinomas (SqCC) can be challenging. In order to clarify the differential diagnostic value of CD5 and CD117 in this setting, we performed a large scale expression study of both markers in 1465 non-small cell lung cancer (NSCLC) cases.   Methods: Tissue microarrays of formalin-fixed paraffin-embedded resection specimens of 1465 NSCLC were stained with antibodies against CD117 and CD5. Positivity of both markers was correlated with clinicopathological variables.   Results: CD117 was positive in 145 out of 1457 evaluable cases (9.9 %) and CD5 was positive in 133 out of 1427 evaluable cases (9.3 %). 28 cases (1.9 %) showed coexpression of CD117 and CD5. Among the 145 cases that were positive for CD117, 97 (66.8 %) were adenocarcinomas (ADC), 34 (23.4 %) were SqCC, 5 (3.4 %) were adenosquamous carcinomas (ADSqCC), 8 (5.5 %) were large cell carcinomas (LC), and one (0.6 %) was a pleomorphic carcinoma (PC). In the CD5 positive group consisting of 133 cases, 123 (92.4 %) were ADC, 0 (0 %) were SqCC, 4 (3.0 %) were ADSqCC, 3 (2.2 %) LC and 3 (2.2 %) were PC. None of the 586 SqCC showed expression of CD5. No association of CD117- or CD5 positivity to patients’ age, pathological stages or to T-, N-, or M- categories was observed.   Conclusions: A substantial subset of NSCLC exhibit positivity of CD117 and CD5. Since CD5 expression was not observed in pulmonary SqCC, but is expressed in the majority of thymic squamous cell carcinomas, the application of this immunomarker is a valuable tool in the differential diagnosis of thoracic neoplasms.
date: 2015
publisher: BioMed Central
id_scheme: DOI
ppn_swb: 165552108X
own_urn: urn:nbn:de:bsz:16-heidok-199191
language: eng
bibsort: KRIEGSMANNDIFFERENTI2015
full_text_status: public
publication: Diagnostic Pathology
volume: 10
number: 2010
place_of_pub: London
pagerange: 1-6
issn: 1746-1596
citation:   Kriegsmann, Mark ; Muley, Thomas ; Harms, Alexander ; Tavernar, Luca ; Goldmann, Torsten ; Dienemann, Hendrik ; Herpel, Esther ; Warth, Arne  (2015) Differential diagnostic value of CD5 and CD117 expression in thoracic tumors: A large scale study of 1465 non-small cell lung cancer cases.  Diagnostic Pathology, 10 (2010).  pp. 1-6.  ISSN 1746-1596     
document_url: https://archiv.ub.uni-heidelberg.de/volltextserver/19919/1/13000_2015_Article_441.pdf