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primary topic: Deleted in Malignant Brain Tumors 1 (DMBT1) is present in hyaline membranes and modulates surface tension of surfactant

Deleted in Malignant Brain Tumors 1 (DMBT1) is present in hyaline membranes and modulates surface tension of surfactant
type: AcademicArticle
type: Article
abstract: Background: Deleted in Malignant Brain Tumors 1 (DMBT1) is a secreted scavenger receptor cysteine-rich protein that binds various bacteria and is thought to participate in innate pulmonary host defense. We hypothesized that pulmonary DMBT1 could contribute to respiratory distress syndrome in neonates by modulating surfactant function. Methods: DMBT1 expression was studied by immunohistochemistry and mRNA in situ hybridization in post-mortem lungs of preterm and full-term neonates with pulmonary hyaline membranes. The effect of human recombinant DMBT1 on the function of bovine and porcine surfactant was measured by a capillary surfactometer. DMBT1-levels in tracheal aspirates of ventilated preterm and term infants were determined by ELISA. Results: Pulmonary DMBT1 was localized in hyaline membranes during respiratory distress syndrome. In vitro addition of human recombinant DMBT1 to the surfactants increased surface tension in a dose-dependent manner. The DMBT1-mediated effect was reverted by the addition of calcium depending on the surfactant preparation. Conclusion: Our data showed pulmonary DMBT1 expression in hyaline membranes during respiratory distress syndrome and demonstrated that DMBT1 increases lung surface tension in vitro. This raises the possibility that DMBT1 could antagonize surfactant supplementation in respiratory distress syndrome and could represent a candidate target molecule for therapeutic intervention in neonatal lung disease.
date: 2007
volume: 8
issue: 69
is part of: Respiratory Research
author list: authors
type: EPrint
type: ArticleEPrint
is part of: repository
has document: Deleted in Malignant Brain Tumors 1 (DMBT1) is present in hyaline membranes and modulates surface tension of surfactant (PDF)
has document: Deleted in Malignant Brain Tumors 1 (DMBT1) is present in hyaline membranes and modulates surface tension of surfactant (Other)
subject: 610 Medizin

Deleted in Malignant Brain Tumors 1 (DMBT1) is present in hyaline membranes and modulates surface tension of surfactant (PDF)
type: Document
has file: 12931_2007_Article_607.pdf
has part: 12931_2007_Article_607.pdf

BioMed Central
type: Organization

Respiratory Research
type: Collection
issn: 1465993X

Nikolaus Gassler
type: Person
given name: Nikolaus
family name: Gassler

Jan Mollenhauer
type: Person
given name: Jan
family name: Mollenhauer

Marcus Renner
type: Person
given name: Marcus
family name: Renner

Mathias Hafner
type: Person
given name: Mathias
family name: Hafner

Burkhard M Helmke
type: Person
given name: Burkhard M
family name: Helmke

Johannes Pöschl
type: Person
given name: Johannes
family name: Pöschl

Dominik Hartl
type: Person
given name: Dominik
family name: Hartl

Hanna Müller
type: Person
given name: Hanna
family name: Müller

Matthias Griese
type: Person
given name: Matthias
family name: Griese

Annemarie Poustka
type: Person
given name: Annemarie
family name: Poustka

Caroline End
type: Person
given name: Caroline
family name: End

Christel Weiss
type: Person
given name: Christel
family name: Weiss

Deleted in Malignant Brain Tumors 1 (DMBT1) is present in hyaline membranes and modulates surface tension of surfactant (Other)
type: Document
is version of: Deleted in Malignant Brain Tumors 1 (DMBT1) is present in hyaline membranes and modulates surface tension of surfactant (PDF)
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Deleted in Malignant Brain Tumors 1 (DMBT1) is present in hyaline membranes and modulates surface tension of surfactant (Other)
type: Document
is version of: Deleted in Malignant Brain Tumors 1 (DMBT1) is present in hyaline membranes and modulates surface tension of surfactant (PDF)
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Deleted in Malignant Brain Tumors 1 (DMBT1) is present in hyaline membranes and modulates surface tension of surfactant (Other)
type: Document
is version of: Deleted in Malignant Brain Tumors 1 (DMBT1) is present in hyaline membranes and modulates surface tension of surfactant (PDF)
is volatile version of: Deleted in Malignant Brain Tumors 1 (DMBT1) is present in hyaline membranes and modulates surface tension of surfactant (PDF)
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Deleted in Malignant Brain Tumors 1 (DMBT1) is present in hyaline membranes and modulates surface tension of surfactant (Other)
type: Document
is version of: Deleted in Malignant Brain Tumors 1 (DMBT1) is present in hyaline membranes and modulates surface tension of surfactant (PDF)
is volatile version of: Deleted in Malignant Brain Tumors 1 (DMBT1) is present in hyaline membranes and modulates surface tension of surfactant (PDF)
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Deleted in Malignant Brain Tumors 1 (DMBT1) is present in hyaline membranes and modulates surface tension of surfactant (Other)
type: Document
is version of: Deleted in Malignant Brain Tumors 1 (DMBT1) is present in hyaline membranes and modulates surface tension of surfactant (PDF)
is volatile version of: Deleted in Malignant Brain Tumors 1 (DMBT1) is present in hyaline membranes and modulates surface tension of surfactant (PDF)
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primary topic: Deleted in Malignant Brain Tumors 1 (DMBT1) is present in hyaline membranes and modulates surface tension of surfactant

610 Medizin
type: Concept
preferred label: 610 Medical sciences Medicine @en