title: Simplification of biochemical models: a general approach based on the analysis of the impact of individual species and reactions on the systems dynamics
creator: Surovtsova, Irina
creator: Simus, Natalia
creator: Hübner, Katrin
creator: Sahle, Sven
creator: Kummer, Ursula
subject: 570
subject: 570 Life sciences
description: Background: Given the complex mechanisms underlying biochemical processes systems biology researchers tend to build ever increasing computational models. However, dealing with complex systems entails a variety of problems, e.g. difficult intuitive understanding, variety of time scales or non-identifiable parameters. Therefore, methods are needed that, at least semi-automatically, help to elucidate how the complexity of a model can be reduced such that important behavior is maintained and the predictive capacity of the model is increased. The results should be easily accessible and interpretable. In the best case such methods may also provide insight into fundamental biochemical mechanisms.   Results: We have developed a strategy based on the Computational Singular Perturbation (CSP) method which can be used to perform a "biochemically-driven" model reduction of even large and complex kinetic ODE systems. We provide an implementation of the original CSP algorithm in COPASI (a COmplex PAthway SImulator) and applied the strategy to two example models of different degree of complexity - a simple one-enzyme system and a full-scale model of yeast glycolysis.   Conclusion: The results show the usefulness of the method for model simplification purposes as well as for analyzing fundamental biochemical mechanisms. COPASI is freely available at http://www.copasi.org.
publisher: BioMed Central
date: 2012
type: Article
type: info:eu-repo/semantics/article
type: NonPeerReviewed
format: application/pdf
identifier: https://archiv.ub.uni-heidelberg.de/volltextserverhttps://archiv.ub.uni-heidelberg.de/volltextserver/20076/1/12918_2011_Article_857.pdf
identifier: DOI:
identifier: urn:nbn:de:bsz:16-heidok-200760
identifier:   Surovtsova, Irina ; Simus, Natalia ; Hübner, Katrin ; Sahle, Sven ; Kummer, Ursula  (2012) Simplification of biochemical models: a general approach based on the analysis of the impact of individual species and reactions on the systems dynamics.  BMC Systems Biology, 6 (14).  pp. 1-16.  ISSN 1752-0509     
relation: https://archiv.ub.uni-heidelberg.de/volltextserver/20076/
rights: info:eu-repo/semantics/openAccess
rights: Please see front page of the work (Sorry, Dublin Core plugin does not recognise license id)
language: eng