title: The history of neuromyelitis optica creator: Jarius, Sven creator: Wildemann, Brigitte subject: 610 subject: 610 Medical sciences Medicine description: The discovery of a novel serum autoantibody (termed NMO-IgG or AQP4-Ab) in a subset of patients in 2004 has revived interest in neuromyelitis optica (NMO). While the history of classical multiple sclerosis has been extensively studied, only little is known about the history of NMO. In the present article, we provide a comprehensive review of the early history of this rare but intriguing syndrome. We trace the origins of the concept of NMO in the 19th century medical literature and follow its evolution throughout the 20th and into the 21st century. Finally, we discuss recent proposals to revise the concept of NMO and explain why there is indeed a need for a more systematic and descriptive nomenclature. publisher: BioMed Central date: 2013 type: Article type: info:eu-repo/semantics/article type: NonPeerReviewed format: application/pdf identifier: https://archiv.ub.uni-heidelberg.de/volltextserverhttps://archiv.ub.uni-heidelberg.de/volltextserver/20113/1/12974_2012_Article_797.pdf identifier: DOI: identifier: urn:nbn:de:bsz:16-heidok-201138 identifier: Jarius, Sven ; Wildemann, Brigitte (2013) The history of neuromyelitis optica. Journal of Neuroinflammation, 10 (8). pp. 1-12. ISSN 1742-2094 relation: https://archiv.ub.uni-heidelberg.de/volltextserver/20113/ rights: info:eu-repo/semantics/openAccess rights: Please see front page of the work (Sorry, Dublin Core plugin does not recognise license id) language: eng