title: An open source software for analysis of dynamic contrast enhanced magnetic resonance images: UMMPerfusion revisited
creator: Zöllner, Frank G.
creator: Daab, Markus
creator: Sourbron, Steven P.
creator: Schad, Lothar R.
creator: Schönberg, Stefan O.
creator: Weisser, Gerald
subject: ddc-610
subject: 610 Medical sciences Medicine
description: Background: Perfusion imaging has become an important image based tool to derive the physiological information in various applications, like tumor diagnostics and therapy, stroke, (cardio-) vascular diseases, or functional assessment of organs. However, even after 20 years of intense research in this field, perfusion imaging still remains a research tool without a broad clinical usage. One problem is the lack of standardization in technical aspects which have to be considered for successful quantitative evaluation; the second problem is a lack of tools that allow a direct integration into the diagnostic workflow in radiology.   Results: Five compartment models, namely, a one compartment model (1CP), a two compartment exchange (2CXM), a two compartment uptake model (2CUM), a two compartment filtration model (2FM) and eventually the extended Toft’s model (ETM) were implemented as plugin for the DICOM workstation OsiriX. Moreover, the plugin has a clean graphical user interface and provides means for quality management during the perfusion data analysis. Based on reference test data, the implementation was validated against a reference implementation. No differences were found in the calculated parameters.   Conclusion: We developed open source software to analyse DCE-MRI perfusion data. The software is designed as plugin for the DICOM Workstation OsiriX. It features a clean GUI and provides a simple workflow for data analysis while it could also be seen as a toolbox providing an implementation of several recent compartment models to be applied in research tasks. Integration into the infrastructure of a radiology department is given via OsiriX. Results can be saved automatically and reports generated automatically during data analysis ensure certain quality control.
publisher: BioMed Central
date: 2016
type: Article
type: info:eu-repo/semantics/article
type: NonPeerReviewed
format: application/pdf
identifier: https://archiv.ub.uni-heidelberg.de/volltextserverhttps://archiv.ub.uni-heidelberg.de/volltextserver/20132/1/12880_2016_Article_109.pdf
identifier: DOI:
identifier: urn:nbn:de:bsz:16-heidok-201321
identifier:   Zöllner, Frank G. ; Daab, Markus ; Sourbron, Steven P. ; Schad, Lothar R. ; Schönberg, Stefan O. ; Weisser, Gerald  (2016) An open source software for analysis of dynamic contrast enhanced magnetic resonance images: UMMPerfusion revisited.  BMC Medical Imaging, 16 (7).  pp. 1-13.  ISSN 1471-2342     
relation: https://archiv.ub.uni-heidelberg.de/volltextserver/20132/
rights: info:eu-repo/semantics/openAccess
rights: Please see front page of the work (Sorry, Dublin Core plugin does not recognise license id)
language: eng