eprintid: 20216
rev_number: 12
eprint_status: archive
userid: 1589
dir: disk0/00/02/02/16
datestamp: 2016-03-01 08:07:31
lastmod: 2024-04-27 16:13:54
status_changed: 2016-03-01 08:07:31
type: article
metadata_visibility: show
creators_name: Aly, Moamen M. O. M.
creators_name: Abo-Madyan, Yasser
creators_name: Jahnke, Lennart
creators_name: Wenz, Frederik
creators_name: Glatting, Gerhard
title: Comparison of breast sequential and simultaneous integrated boost using the biologically effective dose volume histogram (BEDVH)
subjects: 610
divisions: 61800
divisions: 63500
abstract: Purpose: A method is presented to radiobiologically compare sequential (SEQ) and simultaneously integrated boost (SIB) breast radiotherapy.   Methods: The method is based on identically prescribed biologically effective dose (iso-BED) which was achieved by different prescribed doses due to different fractionation schemes. It is performed by converting the calculated three-dimensional dose distribution to the corresponding BED distribution taking into consideration the different number of fractions for generic α/β ratios. A cumulative BED volume histogram (BEDVH) is then derived from the BED distribution and is compared for the two delivery schemes. Ten breast cancer patients (4 right-sided and 6 left-sided) were investigated. Two tangential intensity modulated whole breast beams with two other oblique (with different gantry angles) beams for the boost volume were used. The boost and the breast target volumes with either α/β = 10 or 3 Gy, and ipsi-lateral and contra-lateral lungs, heart, and contra-lateral breast as organs at risk (OARs) with α/β = 3 Gy were compared.   Results: Based on the BEDVH comparisons, the use of SIB reduced the biological breast mean dose by about 3%, the ipsi-lateral lung and heart by about 10%, and contra-lateral breast and lung by about 7%.   Conclusion: BED based comparisons should always be used in comparing plans that have different fraction sizes. SIB schemes are dosimetrically more advantageous than SEQ in breast target volume and OARs for equal prescribed BEDs for breast and boost.
date: 2016
publisher: BioMed Central
id_scheme: DOI
ppn_swb: 1655313975
own_urn: urn:nbn:de:bsz:16-heidok-202160
language: eng
bibsort: ALYMOAMENMCOMPARISON2016
full_text_status: public
publication: Radiation Oncology
volume: 11
number: 16
place_of_pub: London
pagerange: 1-7
issn: 1748-717X
citation:   Aly, Moamen M. O. M. ; Abo-Madyan, Yasser ; Jahnke, Lennart ; Wenz, Frederik ; Glatting, Gerhard  (2016) Comparison of breast sequential and simultaneous integrated boost using the biologically effective dose volume histogram (BEDVH).  Radiation Oncology, 11 (16).  pp. 1-7.  ISSN 1748-717X     
document_url: https://archiv.ub.uni-heidelberg.de/volltextserver/20216/1/13014_2016_Article_590.pdf