eprintid: 20231 rev_number: 15 eprint_status: archive userid: 1589 dir: disk0/00/02/02/31 datestamp: 2016-03-02 07:26:28 lastmod: 2024-03-10 04:58:05 status_changed: 2016-03-02 07:26:28 type: article metadata_visibility: show creators_name: Schmahl, Christian creators_name: Herpertz, Sabine C. creators_name: Bertsch, Katja creators_name: Ende, Gabriele creators_name: Flor, Herta creators_name: Kirsch, Peter creators_name: Lis, Stefanie creators_name: Meyer-Lindenberg, Andreas creators_name: Rietschel, Marcella creators_name: Schneider, Miriam creators_name: Spanagel, Rainer creators_name: Treede, Rolf-Detlef creators_name: Bohus, Martin title: Mechanisms of disturbed emotion processing and social interaction in borderline personality disorder: state of knowledge and research agenda of the German Clinical Research Unit subjects: 610 divisions: 63600 divisions: 851200 divisions: 910600 abstract: The last two decades have seen a strong rise in empirical research in the mechanisms of emotion dysregulation in borderline personality disorder. Major findings comprise structural as well as functional alterations of brain regions involved in emotion processing, such as amygdala, insula, and prefrontal regions. In addition, more specific mechanisms of disturbed emotion regulation, e.g. related to pain and dissociation, have been identified. Most recently, social interaction problems and their underlying neurobiological mechanisms, e.g. disturbed trust or hypersensitivity to social rejection, have become a major focus of BPD research. This article covers the current state of knowledge and related relevant research goals. The first part presents a review of the literature. The second part delineates important open questions to be addressed in future studies. The third part describes the research agenda for a large German center grant focusing on mechanisms of emotion dysregulation in BPD. date: 2014 publisher: BioMed Central id_scheme: DOI ppn_swb: 1655494899 own_urn: urn:nbn:de:bsz:16-heidok-202310 language: eng bibsort: SCHMAHLCHRMECHANISMS2014 full_text_status: public publication: Borderline Personality Disorder and Emotion Dysregulation volume: 1 number: 12 place_of_pub: London pagerange: 1-17 issn: 2051-6673 citation: Schmahl, Christian ; Herpertz, Sabine C. ; Bertsch, Katja ; Ende, Gabriele ; Flor, Herta ; Kirsch, Peter ; Lis, Stefanie ; Meyer-Lindenberg, Andreas ; Rietschel, Marcella ; Schneider, Miriam ; Spanagel, Rainer ; Treede, Rolf-Detlef ; Bohus, Martin (2014) Mechanisms of disturbed emotion processing and social interaction in borderline personality disorder: state of knowledge and research agenda of the German Clinical Research Unit. Borderline Personality Disorder and Emotion Dysregulation, 1 (12). pp. 1-17. ISSN 2051-6673 document_url: https://archiv.ub.uni-heidelberg.de/volltextserver/20231/1/40479_2014_Article_12.pdf